Z. Li

This study identifies resting-state network hubs involved in memory consolidation through chemogenetic suppression, showing their causal role beyond the hippocampus.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper identifies LRP8 as a ferroptosis resistance factor in cancer, showing that its loss causes ribosome stalling during GPX4 translation, exposing a vulnerability in cancer cells.

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

The paper presents a power electronic system and magnetic nanoparticles enabling three-channel magnetogenetic neurostimulation with selective heating across different frequency ranges.

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

The paper reanalyzes ancient whole-genome duplication events in leptosporangiate ferns using phylogenetic methods and substitution rate corrections, identifying four WGDs and highlighting methodological uncertainties.

This study evaluates whether a unified model can predict plant and leaf parameters of winter wheat using vegetation indices across growing seasons, finding that hierarchical linear models (HLM) are stable and applicable across seasons for most parameters.

The paper uses gene expression and metabolic flux analysis to show that metabolic scaling occurs in multiple pathways across species, not just oxygen consumption.

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

This study identifies CLE42 as a negative regulator of leaf senescence in Arabidopsis, showing it delays senescence by suppressing the ethylene pathway.

This study shows that methionine metabolism regulates EBV epigenetic states and latency in B-cells, with methionine restriction impairing viral gene silencing and immune evasion.

This study shows miR155 inhibits osteogenesis and reduces bone mass by targeting S1PR1, suggesting miR155 inhibition could promote bone regeneration.

The paper analyzes histone modifications and chromatin accessibility in Phytophthora infestans to reveal distinct genomic compartments and their association with virulence factor genes.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study demonstrates that selective PIN1 inhibition in CAFs and engagement of T lymphocytes using a bispecific system effectively eradicates pancreatic tumors in mice.

The paper shows that transposon-derived sequences were coopted into F-box genes in Caenorhabditis nematodes, potentially aiding in innate immunity against pathogens.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

This study identifies the EMC complex's role in regulating intestinal stem cell proliferation via the Hippo pathway in Drosophila, showing its negative regulation and evolutionary conservation.

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This study shows that hemagglutinin stability affects influenza A virus susceptibility to Arbidol, with stabilized mutants being more sensitive and destabilized ones more resistant.

This study investigates the structural basis of SARS-CoV-2 Omicron variant's immune evasion and transmissibility using cryo-EM, revealing conformational changes and enhanced ACE2 binding.

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.