Z. Li

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

The paper reports cryo-EM structures of gRAMP-crRNA and gRAMP-crRNA-TPR-CHAT complexes, revealing how TPR-CHAT discriminates between self and non-self RNA targets through conformational changes.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This paper designs optimized monophasic TMS pulses that reduce coil heating while maintaining neuromodulation effectiveness, enabling higher pulse rates.

This study shows that peptide sequences from ostrich eggshells survived for 6.5-9 million years, extending the known preservation of ancient proteins to the Miocene.

This study shows that the Drosophila Toll pathway and specific Bomanins enhance resilience to Aspergillus mycotoxins by mitigating toxin effects rather than directly killing pathogens.

This study identifies heterocateny as a structural variation caused by HPV integration, promoting intratumoral heterogeneity and clonal evolution in oropharyngeal cancers.

The paper identifies a long non-coding RNA that regulates IRF8 autoactivation through a negative feedback loop in dendritic cell differentiation.

This study uses cryo-EM and HS-AFM to determine the structure of Twinkle helicase and reveals its DNA capture and translocation mechanism, highlighting disease-related mutations and stochastic ATP hydrolysis.

This study identifies PDLP5 and PDLP6 as proteins regulating plasmodesmal function at specific cell interfaces in Arabidopsis by interacting with SUS6 and CalS7 to control callose deposition.

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

The paper identifies BNIP5 and Bcl-G as anti-apoptotic BH3-only proteins that inhibit Bak activation, preventing apoptosis.

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

The paper identifies how MBNL proteins localize RNAs via kinesin interaction and membrane docking, using a modular approach to study RNA-binding protein functions.

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

This paper develops a self-catalyzed system to produce stable, low-immunogenic circRNAs for therapeutic protein expression, showing improved efficacy compared to linear mRNAs.

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

The paper develops a red-shifted NanoLuc variant (QLuc) and uses it for in vivo immunobioluminescence imaging to improve deep-tissue visualization in mice.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.