Z. Li

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study shows Hantaan virus uses mitochondrial OXPHOS for replication, driven by AKT activation and PNPT phosphorylation.

The paper identifies GauERF105 as a key gene involved in cotton resistance to Verticillium wilt through transcriptome analysis and functional validation.

This study develops DNA origami nanomedicine to scavenge ROS and NO in M1 macrophages, converting them to M2 subtype and reducing RA inflammation in mice.

This paper introduces a method to efficiently enrich cancer-related exosomes using DNA-tetrahedron nanoweights, achieving high sensitivity and specificity in clinical samples.

The paper develops a model to predict force recruitment in neuromuscular magnetic stimulation using 3D anatomical models and experimental data.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

The paper investigates the origin of thymidylate and folate metabolism in Asgard archaea, finding evidence of horizontal gene transfer from bacteria.

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

This study shows that reduced graphene oxide prolongs connexin 43 expression in myoblasts, enhancing myogenesis and contraction force in engineered muscle, leading to improved performance in a biohybrid pump.

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

This study shows that traumatic brain injury (TBI) rapidly induces splenic dendritic cell maturation via FLT3/FLT3L signaling, which is enhanced by ethanol intoxication.

The paper determines the near-atomic structure of the Saccharomyces cerevisiae nuclear pore complex inner ring, revealing its assembly and functional dynamics.

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

This study shows that two pheasant species have experienced recurrent gene flow during speciation, with evidence of long-term gene flow after initial divergence and ongoing contact in recent times.

This study evaluates drought tolerance in green super rice by analyzing physiological traits and gene expression under drought stress, identifying drought-responsive genes and traits associated with higher tolerance.

This study screens 277 gut bacterial strains to define innate immune responses, showing strain-specific and phylum-level variations in immune activation.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

This study uses single-cell RNA-sequencing to analyze immune cell changes in myeloma progression and identifies potential therapeutic targets for early intervention.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.