Z. Liu

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This study uses electron tomography to analyze the structural transformation of prolamellar bodies into grana thylakoids in Arabidopsis cotyledons and identifies the role of CURT1 proteins in this process.

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

This study investigates the role of GDF15 in APAP-induced liver injury in mice, finding no significant ameliorative effect from overexpression or supplementation of GDF15.

This study investigates the functional roles of OsCKX genes in rice by generating mutants, revealing functional overlap and subfunctionalization, and identifying gene expression changes related to auxin and cytokinin pathways.

This study identifies D-AS2 as a noncoding RNA that promotes chemoresistance in SCC by activating YAP signaling through the PLD/PA axis, and shows that targeting D-AS2 sensitizes SCC to cisplatin.

This study identifies Lyve-1+ perivascular macrophages that form nests and contribute to chemotherapy resistance by excluding CD8+ T-cells and relying on IL-6 and CCR5/CCL3/4 signaling.

This study uses a coarse-grained model to simulate the folding of Adenylate Kinase, revealing cooperative domain interactions and folding heterogeneity in a multiply connected multidomain protein.

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

This paper describes a prebiotically plausible mechanism for aminoacyl-RNA synthesis using phosphoramidate-ester intermediates and mild acid hydrolysis.

This study shows ethylene improves root hypoxia tolerance by reducing reactive oxygen species and inducing growth cessation in Arabidopsis thaliana.

This study identifies OsDML4 as a demethylase gene whose knockout under high temperature causes floury endosperm by altering DNA methylation and gene expression in rice.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

The paper introduces a rapid, highly multiplexed protein detection method for brain tissue, enabling simultaneous detection of 31 proteins in 2 hours with high sensitivity and resolution.

This study uses cryoEM to analyze the structure and dynamics of the Rieske head domain in Candida albicans Complex III and shows how Inz-5 alters its conformational equilibrium.

The paper reports the 3.9 Å resolution structure of the Arabidopsis thaliana NDH-PSI supercomplex, revealing its assembly and interactions.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study uses electron microscopy to examine plastid conversion in Arabidopsis, showing CURT1A and CURT1C have distinct roles in etioplast to chloroplast development.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

This study identifies circRNA expression patterns in healing and non-healing wounds and finds two circRNAs that impair keratinocyte migration while promoting proliferation in non-healing venous ulcers.

This study identifies two isoforms of TSP-14 in C. elegans, showing they have distinct localization and functions in development.

This study investigates the role of viruses in wastewater treatment plants, finding they can enhance contaminant degradation but also spread antibiotic resistance.

This paper investigates the R5L mutation in Tau, showing it does not reduce microtubule-binding affinity but alters N-terminal structure, impairing Tau complex formation on microtubules.

The paper presents Cryo-EM structures of ABCD1 in different conformational states, revealing how ATP and substrate binding regulate its transport mechanism and disease-related mutations.

This study identifies a broadly neutralizing antibody against sarbecoviruses that targets the ACE2 binding site and shows high resistance to escape mutations.

This study shows AMPK and UPR interact via a positive feedback loop in muscle cells exposed to palmitate, with AMPK agonists enhancing UPR gene expression.

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.