Z. Wang

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.

This study examines how different microbial metabolic strategies affect community resilience and feasibility in fluctuating environments, finding that sequential utilizers are more resilient but less feasible than co-utilizing communities.

This study identifies thrombosis as a risk of lung-targeted cationic lipid nanoparticles and proposes solutions to mitigate clotting without compromising targeting.

This study characterizes the multivalent interactions of XRCC4 and XLF CTRs, showing they form condensates that enhance DNA ligation in vitro and suggest roles in NHEJ dynamics and cancer biology.

This study examines how SARS-CoV-2 spike glycosylation affects viral function and neutralization sensitivity to antibodies.

This study examines the relationship between phenotypic and genomic evolution in Fagales, finding an 'early burst' model of diversification linked to gene duplication and genomic conflict during the Cretaceous.

De novo designed protein templates promote nucleation of nano-calcite and direct its growth by oriented particle attachment.

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

This study integrates the MEP pathway into E. coli to enhance terpene production, finding that balancing pathway intermediates maximizes geraniol yield.

This paper introduces a method to identify lipid-protein interactions using lipidomic lipid exchange-mass spectrometry and applies it to study three membrane proteins.

The paper characterizes a novel hormone receptor positive mammary adenocarcinoma model, MCa-P1362, showing stromal-cell interactions drive tumor growth, metastasis, and drug resistance.

This study develops a mucosal nanovaccine that enhances both systemic and lung-specific immunity against SARS-CoV-2 in mice through intranasal and intramuscular delivery.

This paper identifies WNK1 as essential for macrophage lineage fidelity, showing its role in preventing myeloid progenitors from differentiating into neutrophils.

This study investigates BRAF activation mechanisms by analyzing domain-specific and RAS isoform-specific interactions using experimental assays.

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

This study reveals the 3D structure of relaxed cardiac sarcomeres using cryo-electron tomography, showing how thick filament components interact and function in muscle contraction.

The paper demonstrates an integrated wastewater treatment process that achieves nitrite accumulation through comammox and unknown AOBs, revealing their role in short-cut nitrogen removal.

This study evaluates the antiviral effects of two nucleos(t)ide analogs against vaccinia and mpox viruses in human fibroblasts, finding potent inhibition with low EC50 values and validating a new reporter tool for inhibitor screening.

This study shows that inhibiting CDK12 in cancer cells activates P-TEFb, leading to increased dependence on P-TEFb for transcriptional elongation and hypersensitivity to P-TEFb inhibitors.

This study improves a DNA polymerase's ability to incorporate modified nucleotides through combinatorial mutagenesis, resulting in a 20-fold efficiency gain.

This study identifies galectin-3 as a factor that inhibits mitochondrial function and causes cell cycle arrest in CD8+ T cells of severe/critical COVID-19 patients, with potential therapeutic implications.

This study shows that FASN-deficiency leads to a cytosol-to-mitochondria citrate flux via IDH1 and CTP, which helps cancer cells resist oxidative stress during detachment.

This paper develops FRESH 3D bioprinted cardiac tissues to improve in vitro pharmacology and toxicology screening by mimicking native-like physiological responses to adrenergic agonists.

This study uses 19F NMR to show that different GPCR phosphopeptides and PIP2 induce distinct activation mechanisms in β-arrestin 1.

This study shows that inhibiting YAP in tumor cells enhances MHC-I and CXCL10 expression, boosting antitumor immunity and improving response to anti-PD1 therapy without requiring IFNγ signaling.

The paper identifies a type 10 secretion system in Yersinia entomophaga that releases Tc toxins via controlled cell lysis, revealing a novel lytic mechanism for toxin export.

This study evaluates how differentiation state and culture conditions affect the neuroregenerative bioactivity of extracellular vesicles (EVs) from neural stem/progenitor cells (NPSCs).