Z. Zhao

This study maps transcriptome changes in Borrelia burgdorferi during tick-borne transmission by analyzing gene expression over four days in ticks.

The paper examines how tidal fluctuations and human disturbances affect microbiota structure and assembly in intertidal groundwater-surface water systems, identifying rhythmic microbial patterns and their environmental drivers.

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

This study shows that extracellular matrix stiffness influences fibroblast differentiation by modulating DNMT1 expression via microtubule polymerization.

The paper determines the structure of a cyanobacterial PSII D1/D2 assembly complex with Ycf48 bound, showing its role in protecting the Mn4CaO5 cluster site during PSII biogenesis.

This paper examines the biofilm interactions between Ralstonia insidiosa and Chryseobacterium gleum strains from the ISS and terrestrial sources, finding that ISS strains show enhanced biofilm formation not observed in terrestrial strains.

This paper demonstrates a method to efficiently conjugate biomacromolecules to antibodies using modified Fc glycan and an engineered enzyme, enabling rapid and homogeneous antibody conjugates with therapeutic applications.

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

This study establishes a Tetrasphaera-enriched microbiome for enhanced biological phosphorus removal using allylthiourea, achieving high nutrient removal and recovery.

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

This study compares thermal stress responses and transcriptomic profiles of different shell colour morphs in the snail Batillaria attramentaria, finding that dark morphs exhibit preparative defense strategies and higher cardiac thermal tolerance.

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

This study investigates the effects of FABP1 and FAS overexpression on collagen III and cross-linking in Zongdihua pig tissues, identifying their roles in fat deposition.

This study investigates how protein condensates interact with membranes, leading to morphological changes and introduces a theoretical framework to describe these interactions.

The paper uses molecular dynamics simulations to show how prestin's lipid interactions influence membrane deformation and sound amplification in outer hair cells.

This study identifies a necroptosis-related gene signature (NRGscore) to predict prognosis and therapeutic response in bladder cancer patients using TCGA data.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This paper introduces Nano2RED, a rapid, affordable diagnostic platform using nanobody-functionalized nanoparticles to detect viral antigens with high sensitivity and speed.

This study investigates how hydrostatic pressure affects deep-sea microbial carbon cycling, finding that piezophilic and piezotolerant prokaryotes dominate, while piezosensitive bacteria show increased activity under reduced pressure.

This study maps single-cell transcriptomes and T cell repertoires in Behcet's disease to identify immune mechanisms and T cell trajectories in vascular and dermal manifestations.

This study identifies βγ-CAT as a fasting-responsive pore-forming protein that facilitates macromolecular nutrient transport via exosome-mediated uptake in starved muscle cells.

This study identifies POU2AF2 as a co-activator of POU2F3 in SCLC, showing it maintains chromatin accessibility and enhancer activity essential for tuft cell marker expression.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

The paper develops a method using peptidiscs and proteomics to stabilize and identify detergent-sensitive membrane protein complexes, demonstrating its effectiveness with the E. coli Sec system.

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

This study identifies functional determinants of Tae1, a bacterial T6SS amidase toxin, showing that its antimicrobial potency depends on substrate topology and cellular context.

The paper identifies sustained epigenomic changes in hematopoietic stem and progenitor cells after COVID-19, which influence innate immune cell function and inflammation.

This study investigates how feed-borne bacteria affect gut microbiota in farmed juvenile Takifugu obscurus, showing that slower growth is linked to greater microbiota instability and increased feed source influence.

This study identifies shifts in lung macrophage composition linked to COVID-19 severity and recovery, suggesting therapeutic strategies targeting macrophage function.