Z. Zhao

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

The paper identifies two distinct ER tubule forms, R1 and R2, regulated by Rtn4 and Climp63, with functional implications for ER structure and dynamics.

This study shows that Zika virus causes placental pyroptosis via GSDME activation, leading to adverse fetal outcomes.

The paper identifies a role for the clathrin-mediated endocytic machinery in maintaining synaptic EV cargo pools, distinct from its canonical functions in synaptic vesicle recycling.

This study uses super-resolution microscopy to image highly curved membrane structures in synthetic cells, revealing membrane properties and their agreement with theoretical predictions.

This study identifies {beta}{gamma}-CAT as a secretory pore-forming protein that drives macropinocytosis and exosome release to aid water uptake in toads under hypertonic stress.

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

This paper shows that Nef proteins from HIV and SIV use different structural strategies, called R-clamps, to bind SH3 domains, with variations in amino acids at positions 83 and 120.

This study shows that convalescent individuals with or without vaccination maintain neutralizing activity and memory B cells against SARS-CoV-2 for up to one year, with vaccination enhancing breadth and potency against variants.

The paper investigates whether metabolic requirements of leukemia cells reflect normal cell type metabolism, finding that PDH is required in T cell progenitors but not other hematopoietic cells.

This study investigates the role of endopeptidases and class A PBPs in PG synthesis and structural integrity in V. cholerae, showing that aPBPs can compensate for EP insufficiency.

This study compares four single-particle analysis platforms for sizing, counting, and phenotyping extracellular vesicles and synthetic particles, identifying differences in performance across modalities.

The paper examines the antibody response to SARS-CoV-2 mRNA vaccines in pregnant women and their neonates, highlighting the need for further study on vaccine immunology during pregnancy.

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

This study detects S-protein and RBD-specific antibodies in saliva from mRNA-vaccinated healthcare workers after their second dose.

This study identifies a conserved SLiM in p107 that mediates B55 recruitment and dephosphorylation, revealing a general mechanism for PP2A/B55 substrate recognition.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

The paper tests phylogenetic hypotheses for the tent tortoise species complex using genetic and morphological data, finding a four-species classification as the best solution.

This study shows that Polo-like kinase 1 directly controls microtubule-nucleating sites on centrosomes, independent of centrosome size, and is critical for spindle assembly.

The paper develops a shrimp aquaculture ecosystem using predatory fish to control WSSV transmission, effectively preventing outbreaks.

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

The paper develops a new metabolomic method for analyzing rare cell populations, detecting more metabolites in flow-sorted cells and revealing metabolic differences in HSCs and melanoma cells.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.