metabolomics

This study identifies region-specific molecular dysregulation in ADHD brains, including dopamine and metabolite changes, immune responses, and gene modules linked to synaptic pathways.

This study shows that transferring PCB-exposed gut microbiota to offspring reproduces neurobehavioral deficits and induces sex-biased molecular changes in the brain.

This study shows that zearalenone production in Fusarium graminearum is linked to N-acetylglucosamine catabolism, with NAG playing a critical role in both GlcNAc utilization and ZEA tolerance.

The paper reconstructs the asperosaponin biosynthesis pathway in Dipsacus asperoides by integrating genomics, transcriptomics, and biochemical analyses, revealing gene family diversification and glycosylation order.

FeatureMAP improves interpretation of untargeted metabolomics data by integrating annotation, network refinement, and functional analysis, revealing metabolic patterns in Alzheimer's disease.

The paper identifies a pre-transplant γδ T-cell effector signature associated with kidney allograft rejection using multi-omics data from transplant recipients.

The paper develops a method to link genes to metabolism by analyzing commonality in metabolite features associated with mQTLs, demonstrating its effectiveness through three case studies.

The paper quantifies age-related biological dysregulation using metabolomics in older adults and shows it has distinct subsystems linked to health outcomes and DNA methylation.

This paper introduces NORIGAMI, a multi-omics pipeline that combines imaging and deep learning to analyze kidney aging, revealing age-related structural and molecular changes.

This study identifies spatial developmental reprogramming in roots of Schrenkiella parvula under salinity, revealing distinct zones and regulatory programs that enable continued growth.

The paper re-analyses public multi-omics data to characterize the gastric mucosal immune and metabolic landscape of H. pylori infection and identifies CagW as a promising mRNA-LNP vaccine antigen.

This study examines how different dietary fibre regimes affect the gut microbiome, SCFA profiles, and immune responses in zebrafish, showing context-specific effects influenced by sex and dietary context.

This study integrates multi-omics data from Kp infection to identify an itaconate-centred metabolic-immune axis and a host-response signature with high diagnostic accuracy.

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

This study uses multi-omics to uncover Gardnerella genomic features linked to biofilm formation and interspecies interactions in the vaginal microbiome, identifying potential therapeutic targets for bacterial vaginosis.

This study identifies metabolic and transcriptional changes in soybean during soybean cyst nematode infection, revealing immune system remodeling and co-option of symbiotic processes.

This study identifies RAP2.6 as a negative regulator of submergence tolerance in Arabidopsis, showing its interaction with GSNOR1-dependent redox and hormonal signaling.

This study shows maternal folate levels influence adult hematopoietic stem cell function through mitochondrial and chromatin changes in offspring.

The paper identifies glycosyltransferases involved in the biosynthesis of stilbene glycosides in grapevine wood through metabolomic and genetic analyses.

scKNIFE integrates gene expression with functional annotations to identify tumor programs and treatment-related functional variation in breast cancer.

The paper reanalyzes public transcriptomic and metabolomic data to prioritize antigens for improved Brucella vaccines by integrating single-cell and metabolomic atlases.

Akkermansia expansion reduces short-chain fatty acid-producing Firmicutes in human-flora uveitis mice, raising Th1 responses and disease; a Verrucomicrobia/Firmicutes ratio is elevated in uveitis, MS and Crohn's patients.

The paper investigates how cell state transitions in Prochlorococcus marinus MED4 affect transcriptome-proteome alignment through regulatory mechanisms involving RpaB and HimA.

This study investigates how HLB disease affects citrus carbohydrate dynamics compared to source-sink manipulation, finding that HLB alters leaf respiration and stem carbon reserves independently of experimental manipulations.

This study shows ABCA7 deficiency in microglia disrupts lysosomal and lipid homeostasis, impairs phagocytosis, and negatively affects neuronal health in Alzheimer's disease.

This study examines how paternal low protein diet affects mice across generations, revealing sex-specific metabolic changes and intergenerational inheritance patterns.

This study identifies NAD+ limitation and α-ketoglutarate depletion as mechanisms by which pancreatic cancer cells induce muscle atrophy through metabolic rewiring and redox imbalance.

This study identifies how different growth environments affect sesquiterpenoid accumulation in Atractylodes macrocephala rhizome through multi-omics analysis of metabolites, genes, and microbiota.

This study shows how root exudates enhance a non-native PGPR's ability to thrive in the rhizosphere and alter microbial community composition.