Schizophrenia research and treatment

The paper integrates gene expression analysis with computational modeling to show region-specific energy metabolism dysregulation in schizophrenia, identifying key genes and metabolite changes in ACC and DLPFC.

This study investigates how 5-HT7 receptors modulate hippocampal-prefrontal circuits in schizophrenia models, finding that their blockade improves cognitive and emotional symptoms.

This study identifies sex-specific molecular and functional changes in a schizophrenia model, revealing convergent inhibitory deficits through divergent pathways.

This study shows that increased inter-trial latency variability and reduced neural responses both contribute to diminished visual EEG N1 amplitudes in schizophrenia.

This study examines the effects of Grin2a and Akap11 mutations on striatal dopamine dynamics and behavior in mice, revealing distinct impacts on locomotion and neural activity.

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

This study investigates altered sense of agency in first-episode schizophrenia patients using neuroimaging, finding consistent DMN hypo-activation across two independent cohorts.

This paper reviews sex differences in latent inhibition, finding inconclusive evidence but suggesting sex differences in hippocampal processing and vulnerability to perturbations.

The paper identifies CeA-PnC glutamatergic synapses as a therapeutic target for reversing PPI deficits in schizophrenia models using photo-tagging and PRODH-deficient mice.

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

This study uses fMRI to examine neural correlates of schizotypal traits during discourse planning and production, finding trait-specific activation patterns in brain regions associated with theory of mind and social cognition.

This study shows risperidone alters gene expression in specific brain regions of mice, with 21 of the affected genes linked to schizophrenia.

This study investigates semantic structure and retrieval impairments in schizophrenia using word association tasks and MEG, finding idiosyncrasy in semantic representations among patients with speech disorganization.

This study identifies shared genetic loci linking schizophrenia, brain structure, insulin resistance, and inflammation through colocalization analysis.

This study examines how prior information affects perceptual decision-making in psychosis, finding that individuals with psychosis show reduced sensory gain and increased pre-evidence biases compared to healthy controls.

This study identifies striatal hypercholinergic state and thalamostriatal disruption as causes of amotivation in a 22q11DS mouse model.

The paper uses single-cell CRISPRi screens to functionally assess schizophrenia-associated genes, revealing disruptions in neurodevelopmental timing and identifying key regulatory factors.

The paper investigates the association between mosaic loss events in blood and schizophrenia or bipolar disorder, finding increased odds ratios in young-onset cases.

This paper uses aNy-way ICA to identify a cortico-thalamo-cerebellar circuit in schizophrenia, showing altered connectivity and cognitive impairments across multiple datasets.

This study examines structural connectivity disruptions in patients with first episode schizophrenia, finding reduced connectivity in specific brain regions linked to cognitive and language functions.

This study conducts a meta-analysis of GABAergic interneuron deficits in schizophrenia, finding reductions in parvalbumin and somatostatin interneurons, particularly in layers 3/4, and links these deficits to bottom-up processing impairments.

This study investigates the polygenic relationship between cannabis use and schizophrenia using data from the All of Us Research Program, finding independent associations between polygenic scores for cannabis use disorder and schizophrenia.

This study investigates the association between TNF-alpha promoter SNPs and schizophrenia in a Kenyan population, finding no significant genetic link.

The paper investigates how psychosis-like traits affect perceptual inference in different tasks, finding context-dependent alterations in how prior expectations interact with sensory input.

The paper identifies three neuron-specific schizophrenia protein networks enriched for genetic and transcriptional perturbations and validates their disruption in 22q11.2 deletion carriers.

This study investigates the impact of a natural Disc1 deletion in 129S4 mice on social behavior in a semi-natural environment, finding minimal effects.

The paper identifies somatostatine interneurons as key mediators of dopamine-dependent sensory gating in the orbitofrontal cortex, showing their role in suppressing the second response to paired sounds.

This study integrates genetic analysis with single nucleus RNA-seq to identify cell-type specific transcriptomic perturbations in schizophrenia, highlighting mitochondrial dysfunction and protein modification as key factors.

This study examines the morphology of the massa intermedia in schizophrenia, finding smaller size in patients and a link between missing MI and incomplete hippocampal inversion.

The paper identifies a schizophrenia-specific gene expression pattern in the subgenual anterior cingulate cortex using multivariate analysis, highlighting neuro-immune pathways and GWAS-implicated genes.