SARS-CoV-2 and COVID-19 Research

The paper develops a probabilistic framework to predict viral immune escape trajectories, showing that escape is constrained to specific pathways despite vast mutational space.

This study tracks CD4+ T cell memory development after three mRNA vaccinations in SARS-CoV-2-naive individuals, showing primary vaccination drives memory pool size and boosters refine its quality and breadth.

This study uses cryo-ET to examine how two IgGs bind to SARS-CoV-2 S-trimers, revealing structural mechanisms of bivalent binding and antibody avidity.

This study maps epistatic interactions in Omicron SARS-CoV-2 Spike RBD mutations, revealing how mutations interact to affect ACE2 binding and antibody evasion.

This study compares the antiviral activities of neutralizing and non-neutralizing mAbs against SARS-CoV-2, showing that Fc glycosylation significantly impacts antiviral efficacy through ADCC and ADCVI.

This study compares how SARS-CoV-2 and MERS-CoV nsp1 proteins affect host protein synthesis and the integrated stress response, revealing differential impacts on eIF2 phosphorylation and stress granule formation.

This study presents cryo-EM structures of cetacean coronavirus S proteins, revealing unique structural features and glycosylation patterns that highlight structural plasticity and host adaptation.

This study uses Drosophila midgut to investigate SARS-CoV-2-induced gastrointestinal pathogenesis, finding disrupted epithelial architecture, altered lipid homeostasis, and partial mitigation by Plitidepsin.

This study shows SARS-CoV-2 pseudoparticles infect human embryonic stem cell-derived ectoderm more than other germ layers, due to multiple entry pathways, high TMPRSS2, and reduced glycocalyx.

This paper introduces AntiCoV decoy particles, synthetic RNA-protein nanoparticles that inhibit SARS-CoV-2 infection by acting as stable decoy receptors, outperforming soluble ACE2 in neutralization.

This study uses high-speed 3D tracking to show SARS-CoV-2 uses actin for membrane trafficking, preceding viral entry, and correlates with ACE2 expression.

This paper analyzes the molecular mechanisms of broadly neutralizing SARS-CoV-2 antibodies by combining computational methods to reveal how conserved epitopes resist immune escape.

This study evaluates VYD2311, a new monoclonal antibody, showing it neutralizes multiple SARS-CoV-2 variants more effectively than pemivibart, making it a potential candidate for immunocompromised individuals.

This study shows that SARS-CoV-2 accessory proteins ORF3a and ORF9b suppress monocytic inflammatory responses, with Omicron variants enhancing this effect.

This study determines the structure of SARS-CoV-2 spike in complex with contactin 1 and quantifies their interaction, revealing new insights into viral neurotropism.

This study shows that the C-terminal domain of coronavirus E protein can modulate liposome shape by forming amyloid fibers, suggesting a mechanism for membrane interaction in host cells.

This study identifies a cross-reactive germline antibody that can be evolved to neutralize multiple SARS-CoV-2 variants through targeted somatic mutations.

The paper identifies immune mediators linking host susceptibility loci to disease severity across SARS-CoV and SARS-CoV-2 infections.

This study experimentally infects horseshoe bats with SARS-CoV-2, showing low-level persistent viral replication without disease, and identifies host mechanisms that enable viral coexistence.

This study develops a modified SARS-CoV-2 mRNA vaccine, G1-C, that enhances antibody and T cell responses and provides better in vivo protection against the virus.

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

This study shows Musashi1 interacts with SARS-CoV-2 RNA, represses viral translation, and reduces infection in intestinal cells.

This study uses alignment-free machine learning to analyze SARS-CoV-2 Delta variant spike gene sequences before and after Omicron, identifying genomic changes and distinguishing the two groups with high accuracy.

This study investigates the phenotypic effects of naturally occurring MERS-CoV Spike mutations on virus entry and neutralisation, identifying mutations that enhance entry or confer resistance to neutralisation.

This paper identifies NSP3 as a viral phosphatase that interacts with N protein and IRF3 to modulate host phosphorylation and suppress antiviral signaling during SARS-CoV-2 infection.

The paper investigates false positives in SARS-CoV-2 nsp3 protease HTS assays caused by metal contamination and identifies copper and palladium as primary contaminants.

This study identifies spike antibody features, including Fc{gamma}R binding and complement deposition, as strong correlates of protection against SARS-CoV-2 in macaques.

This study evaluates the stability of a β-SARS-CoV-2 VLP vaccine at different temperatures with and without stabilizing excipients, finding improved stability with excipients and long-term stability at -80°C.

This study identifies an acidic cluster motif in the SARS-CoV-2 Spike protein's cytoplasmic domain essential for virion incorporation and infectivity.

This study identifies epitope targeting as the main determinant of ADCC activity in SARS-CoV-2 antibodies, showing that moderate binding and not SHM or neutralization potency drives immune cell activation.