Topic · Infectious Diseases · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
9 papers
Caiwan Guo, Yuanling Yu, Jingyi Liu, Fanchong Jian, Sijie Yang, Weiliang Song, Lingling Yu, Fei Shao, Yunlong Cao
SARS-CoV-2 variant BA.3.2 strongly evades neutralizing antibodies but exhibits low infectivity due to a closed spike conformation, whereas NB.1.8.1 combines high ACE2 affinity with humoral immune escape.
The Lancet Infectious Diseases · Jun 5, 2025Peer-reviewedImmunology✦ In-depth digest
Young‐Jun Park, Chen Liu, Jimin Lee, Jack T Brown, Chengbao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K. Zepeda, Cameron Stewart, Amin Addetia, Caroline J. Craig, M. Alejandra Tortorici, Abeer N. Alshukairi, Tyler N. Starr, , David Veesler
HKU5 merbecoviruses use bat Pipistrellus abramus ACE2 and several artiodactyl ACE2s through a cryo-EM-defined binding mode distinct from other ACE2-using coronaviruses, showing independent evolution of ACE2 usage.
Cell · Feb 7, 2025Peer-reviewedBiochemistry✦ In-depth digest
Alexander Crits‐Christoph, Joshua I. Levy, Jonathan E. Pekar, Stephen A. Goldstein, Reema Singh, Zach Hensel, Karthik Gangavarapu, Matthew Brian Rogers, Niema Moshiri, Robert F. Garry, Edward Charles Holmes, Marion Koopmans, Philippe Lemey, Thomas P. Peacock, Saskia V. Popescu, , Florence Débarre
Reanalysis of public environmental metatranscriptomes from the Huanan market links SARS-CoV-2 positivity to one wildlife stall containing raccoon dog, civet and bamboo rat genetic material.
Cell · Sep 1, 2024Peer-reviewedGenomics✦ In-depth digest
Setu M. Vora, Pietro Fontana, Tianyang Mao, Valerie Leger, Ying Zhang, Tian‐Min Fu, Judy Lieberman, Lee Gehrke, Ming Shi, Longfei Wang, Akiko Iwasaki, Hao Wu
SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.
Proceedings of the National Academy of Sciences · Feb 11, 2022Peer-reviewedMolecular Biology✦ In-depth digest
Alexey Stukalov, Virginie Girault, Vincent Grass, Özge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, , Andreas Pichlmair
Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.
Nature · Apr 12, 2021Peer-reviewedSystems Biology✦ In-depth digest
David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia Richards, Beril Tutuncuoglu, , Natalia Jura
Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.
Nature · Apr 30, 2020Peer-reviewedSystems Biology✦ In-depth digest
Christoph Muus, Malte D. Luecken, Gökçen Eraslan, Avinash Waghray, Graham Heimberg, Lisa Sikkema, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smilie, Karthik A. Jagadeesh, Thu Elizabeth Duong, Evgenij Fiškin, Elena Torlai Triglia, Meshal Ansari, , Wenjun Yan
Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.
bioRxiv · Apr 19, 2020 · PreprintBioinformatics✦ In-depth digest
Soeren Lukassen, Robert Lorenz Chua, Timo B. Trefzer, Nicolas Carlos Kahn, Marc Andre Schneider, Thomas Muley, Hauke Winter, Michael A. Meister, Carmen Veith, Agnes W. Boots, Bianca P. Hennig, Michael Kreuter, Christian Conrad, Roland Eils
Single-cell profiling of lung and bronchial cells places ACE2 mainly in a transient secretory cell state of cultured bronchial epithelium, between goblet and ciliated cells, co-expressing TMPRSS2.
The EMBO Journal · Apr 14, 2020Peer-reviewedGenomics✦ In-depth digest
Michael Getz, Yafei Wang, Gary C. An, Maansi Asthana, Andrew Becker, Chase Cockrell, Nicholson T. Collier, Morgan Craig, Courtney L. Davis, James R. Faeder, Ashlee N. Ford Versypt, Tarunendu Mapder, Juliano F. Gianlupi, James A. Glazier, Sara Hamis, , Paul Macklin
Open-source agent-based PhysiCell model of SARS-CoV-2 infection in lung epithelium; version 5 clears virus in about 6 days in simulation, and delayed T cell arrival increases epithelial loss.
bioRxiv · Apr 2, 2020 · PreprintSystems Biology✦ In-depth digest