Antibiotic Resistance in Bacteria

This study shows that N-acetylcysteine restores carbapenem susceptibility in NDM-producing E. coli through three mechanisms: inhibiting biofilm formation, downregulating blaNDM-5, and enhancing meropenem intracellular accumulation.

This study functionally and structurally characterizes APH(3')-IIb, an enzyme from Pseudomonas aeruginosa that confers resistance to aminoglycoside antibiotics.

This study screens 1,135 antibacterial compounds to find effective treatments for VRE, identifying ridinilazole and CRS3123 as potent and safe candidates.

The paper introduces MICFiller, a Denoising AutoEncoder to impute missing MIC values for Pseudomonas aeruginosa, achieving high accuracy compared to existing methods.

This study evaluates nitroxoline's biphasic bactericidal effect against Acinetobacter baumannii isolates from UTIs, showing optimal efficacy at specific concentrations and highlighting the need for optimized dosing.

This study characterizes a multidrug-resistant E. coli strain from a sepsis patient using whole-genome sequencing and phenotypic testing, revealing extensive AMR genes and taxonomic ambiguity with related species.

The paper analyzes 15,000 bacterial genomes to investigate the presence of antimicrobial resistance (AMR) genes in prophages across human body sites and regions, finding diverse AMR genes associated with prophages.

This paper investigates how enmetazobactam and tazobactam inhibit GES-1, an ESBL, revealing structural and mechanistic differences in their acyl-enzyme complexes.

This study shows that Klebsiella pneumoniae becomes more resistant to beta-lactam antibiotics at low pH due to the activity of specific penicillin-binding proteins.

The paper analyzes macrolide resistance mechanisms in bacterial genomes to inform antimicrobial stewardship in resource-limited settings.

The paper shows that glucose availability increases fosfomycin resistance in Enterobacter cloacae by altering GlpT expression and enhancing fosA gene activity.

The paper tests sulbactam-durlobactam susceptibility in cefiderocol heteroresistant Acinetobacter isolates and finds no heteroresistance, supporting its efficacy and potential prioritization over cefiderocol.

The paper introduces the Sublethal Interaction Factor (SIF) assay to analyze antibiotic combinations at sublethal concentrations, showing high sensitivity and specificity compared to existing methods.

This paper describes the discovery of TXA11114, an efflux pump inhibitor that enhances levofloxacin efficacy against multidrug-resistant Pseudomonas aeruginosa in vivo with a safe toxicology profile.

The paper identifies a compound that disrupts the TolC-AcrA interface of the E. coli efflux pump, leading to pump disassembly and reduced antibiotic resistance.

The paper introduces ROCker models for detecting and typing specific antibiotic resistance genes in short-read sequences, showing improved accuracy over existing methods.

This study quantifies how antibiotic use and genetic resistance determinants affect bacterial lineage dynamics using a Bayesian model and Neisseria gonorrhoeae isolates.

The paper estimates within-host mutation rates of ESBL-producing E. coli and K. pneumoniae using phylodynamic models on longitudinal genomic data from hospitalized patients.

This study compares plasmid datasets to assess how data origin affects inferences about plasmid mobility, antimicrobial resistance, virulence, and host taxonomy.

This study uses CRISPRi screens to analyze fitness effects of the pOXA-48 plasmid in clinical enterobacteria, identifying key genes and mechanisms affecting plasmid stability and transmission.

This study compares how two Acinetobacter baumannii strains from different eras respond to tigecycline, showing historical differences influence transcriptional responses and resistance adaptation mechanisms.

This study compares the fecal microbiome of pigs with and without antibiotic exposure to assess changes in microbial communities and antibiotic resistance genes.

This study shows that non-antibiotic medications increase mutation frequency and antimicrobial resistance in E. coli, particularly when combined.

This study identifies PBP mutations as a mechanism of non-carbapenemase mediated carbapenem resistance in Acinetobacter baumannii through experimental mutagenesis and genomic analysis.

This study investigates how doxycycline post-exposure prophylaxis (doxy-PEP) affects doxycycline resistance in Neisseria commensals and its potential for horizontal gene transfer to pathogens.

This study shows that biased sampling in bacterial genome data leads to poor performance in machine learning models predicting antimicrobial resistance.

The paper tests antibiotic efflux liability by examining reversion rates of AcrB and MexB D408A mutants to wild type in response to substrates and non-substrates.

The paper develops a culture-based method to detect and differentiate beta-lactamase producers in rectal swabs, showing higher specificity and broader detection compared to existing methods.

The paper analyzes protein mutations in A. baumannii to understand their impact on antibiotic resistance.