Pain Mechanisms and Treatments

This study shows artemin induces similar sensitization of sensory neurons in mice and naked mole-rats in vitro, suggesting conserved mechanisms despite differences in pain responses.

The paper identifies peptides based on the autoinhibitory XY linker of PLCβ isoforms that inhibit PLCβ activity and reduce inflammation and pain in a mouse model.

The paper identifies CeA neuronal ensembles that modulate visceral pain and its affective behaviors through optogenetic manipulation and single-nucleus RNA sequencing.

This study shows that sphingomyelin 34:1 induces inflammatory pain and neuronal hyperexcitability in mice with osteoarthritis.

This study shows that androgen receptors in primary sensory neurons regulate mechanical pain sensitivity and sex differences in pain perception.

This study examines gabapentin's effects on human dorsal root ganglia neurons, showing donor-specific electrophysiological responses and transcriptomic changes that are modulated by the drug.

This study shows that C-LTMRs regulate thermosensation and are critical for resolving pain after injury, as their ablation leads to persistent hypersensitivity and altered transcriptional responses.

This study investigates how ultrasound vocalizations from pain-stimulated mice affect pain response and inflammation, showing increased hyperalgesia and altered analgesic effects.

The paper identifies gene expression changes in brain regions associated with chronic pain, highlighting BLA microglia as a key cell type and finding distinct gene expression patterns compared to other pain-related traits.

The paper shows that subjective salience ratings reliably correlate with physiological arousal, supporting their use for salience-matching in pain studies.

This study shows prenatal alcohol exposure enhances morphine-induced pathological pain through NLRP3-mediated proinflammatory immune responses in nerve-injured mice.

This study quantifies the spatio-temporal complexity of EEG responses to thermal pain using PCI, showing sensitivity to temperature, chemical sensitization, and probabilistic stimulus changes.

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

The paper investigates how CASPR2 autoantibody subclasses, particularly IgG4, affect neuronal excitability and potassium channel function in patients with neuropathic pain.

This study shows that nerve injury causes long-term systemic inflammation and pain hypersensitivity, with sex-dependent differences in immune and molecular responses.

This study investigates molecular changes in the ventral tegmental area of mice with chronic pain-induced negative affect, identifying sex-dependent Kv7.2 channel expression and endocannabinoid level alterations.

This study shows FL/FLT3 signaling increases mechanical pain hypersensitivity via IL-1β in male mice, with IL-1β mediating FL's effects on TRPV1 and pain responses.

This paper introduces a novel mouse model of central post-stroke pain (CPSP) using photothrombotic ischemia in the thalamus, showing persistent facial grimace pain and correlating microglial activation with pain severity.

This paper investigates Cav1.2-dependent excitation-transcription coupling in nociceptors, showing it modulates pain sensitivity by affecting gene expression and neuronal function.

This study investigates how metabolic resilience during hormonal aging affects sex-specific recovery from nerve injury in mice using multi-omics analysis.

This study shows that dietary zinc restriction in adult mice causes irreversible allodynia and metabolic changes, which are reversed by zinc repletion.

This study identifies PKM as a metabolic activator of SARM1 in diabetic neuropathy, showing that inhibiting their interaction reduces axonal degeneration.

This study examines how dopamine agonists affect pain-responsive neurons in the central nucleus of the amygdala, finding inhibitory effects on neuronal activity and synaptic transmission.

The paper develops a noninvasive imaging method to measure spontaneous pain in mice using bioluminescence from genetically modified neurons.

The paper characterizes satellite glial cell (SGC) subtypes in mouse and human dorsal root ganglia using single-cell RNA sequencing and spatial techniques, revealing distinct functional roles and spatial organization.

This study evaluates the analgesic effects of intrathecal NaV 1.7 antisense oligonucleotides in rats, showing reduced channel binding and pain behaviors with concentration-dependent knock-down of Scn9a mRNA.

This paper identifies Pdgfrb+ fibroblast and mural cells as contributors to neuropathic pain by showing their increased numbers and expression of pro-algesic mediators in a mouse model.

This study shows JAK inhibitors block RA synovial fluid-induced sensory neuron activation by inhibiting STAT3 phosphorylation and pain gene expression.

This study investigates chronic intermittent ethanol-induced pain in mice, finding it occurs through endocannabinoid-independent mechanisms and is not effectively reversed by tested lipid signaling inhibitors.