Pain Mechanisms and Treatments

The paper decodes naturalistic acute pain states using neural and facial dynamics in epilepsy patients, identifying reliable neurobehavioral markers.

This study shows social exclusion increases physical pain responses through insular neuromodulation in mice, with opposing endocannabinoid and oxytocin signaling.

The paper re-examines the expression and projection patterns of Tacr1 and Gpr83 in spinal projection neurons, finding greater overlap and VPL connectivity than previously reported.

This paper develops a high-content screening platform using hiPSC-derived nociceptors on micro-electrode arrays to identify analgesic drugs with reliable assay performance and functional target validation.

This study identifies neuronal senescence in dorsal root ganglia of aged and injured mice, showing it contributes to sensory dysfunction and is reversible with senolytic treatment.

This study identifies TrkBT1 as the predominant TrkB isoform in sensory neurons, including nociceptors, and shows its functional role in modulating neuronal activity and survival.

This study shows that type I interferons increase excitability of human dorsal root ganglion nociceptors and sensitize TRPV1, contributing to pain.

This paper develops a reversible GlyT2 inhibitor that alleviates neuropathic pain without on-target side effects or addiction liability.

This study examines suzetrigine's effects on human dorsal root ganglion neurons, showing it suppresses spontaneous pain-related discharges but requires longer exposure to affect evoked pain.

This study shows that NRM serotonergic neurons bidirectionally control spinal nociception through different 5-HT receptors, with 5-HT2c mediating analgesia and 5-HT3 causing hyperalgesia.

This study shows that adolescent alcohol exposure causes mechanical allodynia and changes synaptic function in a prefrontal nociceptive circuit in rats.

This study examines how peripheral inflammation in mice affects cerebral blood perfusion using laser speckle contrast imaging and links it to behavioral changes.

This study shows that clock genes in nociceptors affect pain sensitivity differently in males and females across times of day.

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

This study shows oral Langerhans cells regulate tongue innervation via IL-1β and NGF, with microbiota and age affecting this neuroimmune function.

The paper compares the transcriptome of a human sensory neuron-derived cell line with primary and iPSC-derived sensory neurons to assess its utility as a human model for nociceptive signaling.

This study shows that AT1 receptor activation in dorsal horn pericytes causes vasoconstriction and pain hypersensitivity, which can be prevented by losartan.

This study identifies the role of the gracile nucleus in mediating tactile sensitivity and mechanical allodynia during neuropathic pain in mice.

This study identifies a unique ethological signature of pain in a mouse model of CRPS and evaluates the effects of dexmedetomidine on pain behaviors.

This study uses in vivo calcium imaging and home cage monitoring to assess joint neuron activity and locomotor behavior in mouse arthritis models, finding increased spontaneous activity in AIA mice but not PMX mice.

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

The paper identifies distinct neural ensembles in mouse spinal cord encoding mechanical and heat pain and shows their role in affective pain behavior.

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

This study shows that B cell-derived autoreactive IgG and FcγR upregulation drive mechanical allodynia after nerve constriction or crush injury, but not after nerve transection.

The paper characterizes somatostatin-expressing neurons in the anterolateral system, showing their axonal projections and suggesting a role in the affective-motivational dimension of pain.

This paper introduces a magnetogenetic method to bidirectionally control pain circuits in mice using magnetic fields and a fusion protein, showing both excitatory and inhibitory effects on nociceptor activity.

The paper identifies a fast nociceptive pathway that mediates rapid reflexive behavior but not affective pain.

This study shows that inhibiting Piezo2 reduces acute inflammatory and osteoarthritis knee pain in mice using FM-dyes.