Pain Mechanisms and Treatments

This study assesses how ageing and diabetic polyneuropathy affect thermosensory sensitivity and precision, finding similar patterns in cold detection but distinct effects on pain-related parameters.

This study shows that sub-chronic stress causes hypomethylation of the Fkbp5 promoter, increasing chronic pain vulnerability, but reversing this methylation does not prevent pain.

This study uses ultrasensitive proteomics to uncover nociceptor diversity and identify novel pain targets by analyzing protein expression in sensory neurons.

This study shows that CD206+ meningeal macrophages mask mechanical hypersensitivity in male rats after skin incision but not in females.

This study investigates exercise-induced pain modulation in high-fit females, finding that fitness level, not sex, moderates pain relief from high-intensity exercise.

This study investigates whether expectation affects repetition suppression in nociception using EEG and physiological data, finding no significant differences between expected and unexpected stimulus repetitions.

The paper shows that nociceptors use both glutamate and neuropeptides to transmit pain signals, with redundancy in their signaling pathways.

This paper introduces a method to preserve human dorsal root ganglion neurons using Hibernate media, enabling easier access and transport for research.

The paper identifies replicable fMRI correlates of pain sensitivity across multiple pain types and develops a machine learning model to predict pain sensitivity and intervention outcomes.

This study shows that regulatory T cells modulate peripheral neuron activation to restrain skin inflammation by expressing Penk, a precursor for endogenous opioids.

This study investigates the effects of chronic alcohol exposure on peripheral neuropathy in mice, identifying sex, intake duration, and acetaldehyde as key factors in neuroinflammation and hypersensitivity.

This study identifies distinct brainstem circuits activated by splanchnic and pelvic spinal afferent pathways from the mouse colorectum, showing their differential roles in sensory processing and visceromotor responses.

The paper shows that metabolic reprogramming in the spinal cord, driven by injury, leads to chronic pain by suppressing autophagy and nutrient availability, and that dietary intervention can prevent this transition.

The paper develops a human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry that mimics opioid-induced effects through electrophysiological responses.

This study identifies a neural circuit between the periaqueductal gray and lateral septum that mediates acute restraint stress-induced analgesia through synaptic interactions.

This study investigates the thermal grill illusion (TGI) and finds it elicits primary hyperalgesia in males and secondary hyperalgesia in all participants, suggesting spinal dorsal horn integration and involvement of HPC neurons.

The paper examines EEG activity in anesthetized rats to identify neurophysiological markers of acute pain under urethane-induced anesthesia.

The paper identifies ETC regulation as a protective mechanism against excitotoxicity in TRPV1+ sensory neurons using CRISPRi screening and functional experiments.

This study develops humanized anti-Nav1.7 antibodies that show long-lasting analgesic effects without side effects in neuropathic pain models.

This study identifies MMP3, MMP8, and MMP9 as inducers of Ca2+ release in DRG neurons via PAR1 and PLC activation, revealing a novel role for MMP signaling in sensory neurons during inflammation.

This study uses bulk and spatial RNA sequencing to analyze human peripheral nerves in diabetic patients, revealing pathway differences, immune cell shifts, and mRNA localization changes linked to diabetic peripheral neuropathy.

This study identifies an anterior cingulate cortex neuronal ensemble that mediates context-based opioid analgesic tolerance without affecting basal nociception.

This study shows that modulating somatostatin-expressing interneurons in the basolateral amygdala affects different types of neuropathic pain in mice.

This study validates an adapted electronic von Frey (aVF) device for measuring joint pain in rats and assesses its response to analgesics in osteoarthritis models.

The paper shows that nitrous oxide increases anterior cingulate cortex activity in mice, suggesting this activity reflects pain affect even under anesthesia.

This study investigates the role of THIK2 channels in pain regulation through molecular, electrophysiological, and behavioral analyses in knock-out mice, revealing their involvement in limiting neuronal hyperexcitability and suggesting therapeutic potential for chronic pain.

This study investigates how anti-CV2/CRMP5 autoantibodies cause pain in paraneoplastic neurological syndromes and identifies potential treatments.

This study finds that acute aerobic exercise intensity does not significantly affect pain relief in a mixed population, but individual factors like fitness and sex may influence exercise-induced hypoalgesia.

This study evaluates how chronic neuropathic pain affects the antinociceptive and antihyperalgesic effects of MOR agonists in rats, finding no significant differences between SNI and sham groups.

The paper identifies IL-17's role in enhancing pain sensitivity in the gut via PI3K-dependent mechanisms in ulcerative colitis.