Obstructive Sleep Apnea Research

Therapeutic acute intermittent hypoxia does not alter whole-brain cerebrovascular function in healthy individuals

This study examines the effects of therapeutic acute intermittent hypoxia on cerebrovascular function in healthy individuals and finds no significant changes in whole-brain blood flow or reactivity.

Sleep-Related Respiratory Disruption is Associated with Altered Spindle Morphology and Poorer Attention in Children

This study investigates the relationship between sleep-related respiratory disruption and changes in sleep spindle morphology and attention in children, finding that hypopnea is linked to specific spindle alterations and attentional performance.

Social Jet Lag Estimated From CPAP Adherence Data in Two Obstructive Sleep Apnea Cohorts

This study estimates social jet lag from CPAP adherence data in two sleep apnea cohorts, finding it is common, associated with sleep restriction and rebound, and declines with age.

Obstructive Sleep Apnea Syndrome Disrupts Glymphatic-Related Physiological Brain Pulsations

This study examines how obstructive sleep apnea affects brain pulsations related to glymphatic clearance using fNIRS and HRV analysis.

Greater hypoxic burden predicts weaker coordination between brain pulsation and CSF flow on 7T MRI independent of non-hypoxic arousals: Implications for glymphatic activity

This study finds that greater hypoxic burden in OSA is linked to weaker coordination between brain pulsation and CSF flow, suggesting impaired glymphatic activity.

Intermittent Hypoxia Alters Cerebrovascular Recovery After Stroke

This study investigates how intermittent hypoxia worsens cerebrovascular recovery after stroke in rats, showing increased inflammation, oxidative stress, and BBB disruption.

COMPREHENSIVE GENETIC INVESTIGATION REVEALS HETEROGENEOUS PATHWAYS TO OBSTRUCTIVE SLEEP APNEA

This study identifies 14 genome-wide significant loci for obstructive sleep apnea, including three independent of BMI, and highlights genetic pathways involving obesity, neurological, and craniofacial factors.

Spontaneous peripheral oxygen desaturation and apnea events in mice vary by strain and inspired oxygen level

This study shows that mice experience spontaneous oxygen desaturations and apneas that vary by strain and inspired oxygen level, with desaturations often not linked to apneas.

Cell-Specific Transcriptomic and Mito-Nuclear Imbalance in Lungs Under Intermittent Hypoxia in Adult Male Mice.

This study examines real-time transcriptional responses to intermittent hypoxia in lung tissue of male mice, revealing cell-type-specific changes and mito-nuclear imbalance.

Deep Learning Meets Sleep Medicine: A Proof-of-Concept Clustering of Minute-Resolution CPAP Telemetry

This study uses CPAP telemetry data to identify six sleep and adherence phenotypes through deep learning clustering.

Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype

This study identifies gene-environment interactions between excessive daytime sleepiness and genetic variants linked to obstructive sleep apnea severity, revealing novel therapeutic targets.

Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation

The paper investigates how intermittent hypoxia increases H3K27 acetylation through ROS-dependent mechanisms and shows that this is regulated by H3S28 phosphorylation.

Regulatory variation at serotonin receptor 1F (HTR1F) modulates arousals and risk for sleep apnea

The paper identifies regulatory variation at HTR1F associated with sleep apnea risk and arousals, particularly in non-obese individuals.

Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults

The paper shows cerebrovascular pathology mediates the link between REM sleep hypoxemia and entorhinal cortical thickness, which is associated with impaired memory in older adults.

Causal Associations of Sleep Apnea with Alzheimer's Disease and Cardiovascular Disease: a Bidirectional Mendelian Randomization Analysis

This study uses Mendelian randomization to examine causal relationships between sleep apnea and Alzheimer's disease, coronary artery disease, and stroke, finding significant causal effects for CAD and stroke but not AD.

Sleep apnoea in spontaneously hypertensive rats is associated with microvascular rarefaction in the preBotC.

The paper investigates sleep apnoea in spontaneously hypertensive rats and links it to microvascular rarefaction and vascular dementia through neuronal loss and neuroinflammation.

Genome-wide association study of obstructive sleep apnea in the Million Veteran Program uncovers genetic heterogeneity by sex

This study conducts a GWAS of obstructive sleep apnea in the Million Veteran Program, identifying sex-specific genetic loci and highlighting genetic heterogeneity by sex.

An integrated multi-omics analysis of sleep-disordered breathing traits across multiple blood cell types

The paper integrates multi-omics data to analyze how sleep-disordered breathing traits affect gene expression, metabolites, and potential causal pathways across blood cell types.

Next-Generation Sequencing-Based Analysis of HLA Variants in Turkish Patients with Obstructive Sleep Apnea

This study uses high-resolution NGS to identify HLA alleles associated with OSA in Turkish patients, finding several alleles linked to increased or decreased risk.

Detection of sleep apnea from single-channel electroencephalogram (EEG) using an explainable convolutional neural network

This paper develops an explainable CNN to detect sleep apnea from single-channel EEG with 76.7% accuracy and 0.54 MCC, showing it learns delta and beta band biomarkers.

Cholinergic basal forebrain degeneration due to obstructive sleep apnoeaincreases Alzheimer's pathology in mice

This study shows that inducing obstructive sleep apnoea in a mouse model of Alzheimer's disease increases Alzheimer's pathology, including amyloid-beta and inflammatory markers, through mechanisms involving hypoxia and the p75 neurotrophin receptor.

Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank (n=408,317)

This study identifies 42 genetic loci associated with snoring using UK Biobank data and finds that body fat mass influences snoring through Mendelian randomisation.