Developmental Biology and Gene Regulation

This study investigates the role of Patched-related (Ptr) in Drosophila melanogaster by analyzing survival, movement, and lifespan in Ptr23c null mutants.

This study shows that ectoderm tissue properties, influenced by BMP signaling, modulate lateral mesendoderm cell migration during zebrafish gastrulation.

This study shows that lepidopteran scale cells originate from sensory organ precursors through a canonical lineage, supported by live imaging and single-nucleus RNA sequencing.

The paper shows that bHLH transcription factor interactions regulate stemness and bipotential differentiation in Drosophila gut stem cells.

The paper uses single-cell transcriptomics to show that non-interacting signaling pathways prevent tumorigenesis by converging at the transcriptional level to block malignant cell behavior.

The paper uses optogenetics to manipulate Dorsal levels in Drosophila embryos, revealing a critical temporal window for its function in patterning and transcriptional regulation.

This study shows that HSPA2 expression in mouse 2-cell embryos influences the first cell-fate decision by affecting inner cell mass differentiation.

This study examines the expression pattern of UNC5H3 in the developing chick mesencephalon and cerebellum using in situ hybridization.

This study shows that ETV4 and ETV5 regulate lineage specification and embryo patterning in mice by affecting primitive endoderm formation and pluripotency exit.

The paper uses live-imaging to analyze germ granule dynamics in zebrafish embryos, revealing that cytokinetic apparatus drives their movement and that Ybx1 is essential for proper germplasm distribution.

This study shows that Nxn deficiency causes pituitary dysmorphology and reduced Wnt signaling in mice, suggesting potential endocrinological evaluations for Robinow syndrome patients.

This study compares enteric neural crest development in surface and cavefish of Astyanax mexicanus, finding faster migration and differentiation in cavefish and identifying potential genetic mutations affecting endothelin signaling.

The paper uses an agent-based model to simulate how Trail, Colec12, and Dan confine cranial neural crest cells to stereotypical migration pathways in vivo.

The paper shows apical polarity in PrE cells drives robust tissue patterning in blastocysts by guiding migration and breaking symmetry.

The paper reconstructs spatio-temporal gene expression patterns in developing mouse limbs using static snapshots, enabling analysis of gene dynamics across time.

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

This study shows that Prickle2 enhances tissue fluidity during vertebrate neurulation by remodeling apical junctions, facilitating neural tube formation.

This study shows CHD3 regulates BMP signaling during cranial neural crest cell specification by modulating chromatin accessibility and gene expression.

This study examines antero-posterior patterning in brittle stars to understand axial homologies in echinoderms and their evolution.

This paper investigates totipotency and plasticity in the acoel Hofstenia miamia, showing that isolated 4-cell stage macromeres can form whole organisms and that 8-cell stage blastomeres can reprogram to develop into a hatchling worm.

This study shows that cranial neural crest cells are essential for the development of the zebrafish anterior lateral line system, including its neuromasts and ganglia.

The paper shows that xenacoelomorph male gonopore expresses bilaterian hindgut marker genes, suggesting it is homologous to the bilaterian anus.

The paper identifies a genetic circuit in Drosophila that enhances BMP signaling at the distal end of the gradient, enabling insect wing development.

The paper shows that left-right asymmetry in chick embryos begins before the formation of the left-right organizer, detected through biophysical analysis of cellular flows.

The paper examines Hox gene expression in chaetognaths, revealing an extensive repertoire among protostomes and a conserved AP patterning profile similar to the last common bilaterian ancestor.

This study identifies gene regulatory mechanisms that coordinate neuron-type-specific programs with plastic gene expression responses in Caenorhabditis species.

This study investigates how Enhancer of Split transcription factors mediate Notch signaling in Drosophila R7 photoreceptor specification by repressing specific gene expression.

The paper examines Pax6 gene expression in the eyeless arachnid Archegozetes longisetosus to test the hypothesis that Pax6 genes ancestrally patterned the central nervous system rather than eyes in chelicerates.

The paper evaluates the reliability of morphological criteria for staging near-hatching waterfowl embryos and proposes new criteria with higher accuracy.