Developmental Biology and Gene Regulation

POSH (Plenty of SH3): a novel genetic modifier of Myc function in Drosophila

This study identifies POSH as a genetic modifier of Myc function in Drosophila through a genetic screen and functional analysis.

Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

The paper integrates ATAC-seq and RNA-seq data from zebrafish osteoblasts to identify chromatin and transcriptomic signatures and mechanisms of entpd5a regulation.

PHC2-Dependent PRC1 Assemblies Stabilize Motor Neuron Hox Codes

This study shows PHC2-dependent PRC1 assemblies stabilize Hox gene boundaries and motor neuron identities during development.

MYC/MAX balance dictates cell progenitor fate by altering the HOX program in the Drosophila eye

This study shows that altering the MYC/MAX ratio in Drosophila eye progenitors changes cell fate by rewiring HOX gene expression and reprogramming progenitor identity.

Spatiotemporal proteomics reveals dynamic antagonistic gradients shaping signalling waves

The paper uses a microfluidics and proteomics approach to study dynamic protein gradients in mouse embryos, revealing antagonistic ligand-receptor patterns that regulate Wnt oscillations and somite formation.

NOTCH-driven oscillations control cell fate decisions during intestinal homeostasis

The paper shows that NOTCH-driven Hes1 oscillations with different periods control cell fate decisions in intestinal stem cells, influencing secretory and absorptive lineage commitment.

Cycles upon cycles - Temperature Scaling of Medaka Development

The paper investigates how temperature cycles affect medaka embryonic development, revealing temperature-insensitive spatial patterns that compensate for temperature-sensitive temporal oscillations.

The regulatory logic of a dose-dependent developmental fate decision

The paper identifies the molecular mechanism by which low doses of ERK signaling induce specific developmental outcomes in Drosophila embryos.

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

Possible function of Hox2 in atrial siphon fusion of the ascidian Ciona

This study shows Hox2 is required for atrial siphon fusion in Ciona, with Hox2-knockout animals retaining two siphons and lacking cupular organs.

Stochastic Modeling of BMP Heterodimer-Receptor Interactions Shows Emergence of Low-Pass Filtering Behavior

The paper develops a stochastic model of BMP receptor interactions to show the heterodimer-heterotetramer complex functions as a low-pass filter in zebrafish dorsoventral axis formation.

The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms

The paper identifies lin-15A as a Licenser that facilitates transdifferentiation by antagonizing identity safeguarding mechanisms in C. elegans.

Embryonic and larval development of the Pacific saury Cololabis saira: Distinctive characteristics of a rapidly growing beloniform fish

The paper documents the embryonic and larval development of Pacific saury, highlighting unique developmental patterns and rapid growth compared to related species.

Regional Signaling Controls Stem Cell-Mediated Regeneration in an Invertebrate Chordate

The paper identifies region-specific signaling cues that control stem cell-mediated regeneration in the invertebrate chordate Ciona robusta.

Regeneration can take place across Drosophila compartments or segments with different Hox gene expression

This study shows that Hox gene expression differences do not block regeneration across Drosophila segments or compartments, though some regenerative limits exist in specific genetic backgrounds.

Gene co-expression networks reveal differential developmental modularity in Mammalian limbs

The paper uses gene co-expression networks to analyze limb development in mice, bats, and opossums, finding increased modularity in bat forelimb development.

Description of the embryonic development in the convict cichlid (Amatitlania nigrofasciata)

This paper describes the embryonic development of the convict cichlid from fertilization to hatching, providing a staging table for comparative developmental studies.

A collagen orientation switch reshapes fin architecture

This study shows that loss of actinodin1 and actinodin2 genes in fish causes collagen fibers to orient perpendicularly to the epidermis, leading to fin reduction and thickening, and reveals similar patterns in tetrapod limbs.

Resolving cell lineages and gene functions in the developing mouse gastrointestinal tract using in utero transduction

This study uses in utero lentiviral transduction to resolve clonal relationships and gene functions in developing mouse gut lineages, revealing distinct developmental patterns in mesenchyme and enteric nervous system.

Segmentation gene expression and function in Vanessa cardui, an emerging model for Lepidoptera

This study investigates PR-gene expression and function in Vanessa cardui, finding that lepidopterans use a subset of Drosophila PR-gene orthologs and lack hemipteran PR-orthologs for segmentation.

Abalone genomics reveals an ancient asymmetry axis and the multifunctionality of the mantle

The paper constructs a chromosome-level genome for Haliotis iris and identifies an ancient regulatory axis and a multifunctional mantle involved in body asymmetry and melanogenesis.

Shifts in embryonic oxygen levels cue heterochrony in limb initiation

The paper identifies differential oxygen levels as a driver of heterochrony in limb development between avian and mammalian embryos.

PRDM3 and PRDM16 define cranial neural crest cell states in zebrafish development

The paper identifies direct transcriptional targets of Prdm3 and Prdm16 in zebrafish neural crest cells using CUT&RUN and shows altered gene expression in mutants.

Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio

This study shows Pax6 homologs are required for patterning both visual systems in the daddy-longlegs Phalangium opilio, with double knockdown causing median eye defects and loss of vestigial eyes.

Brachyury expression levels predict lineage potential and axis-forming ability of in vitro derived neuromesodermal progenitors

The paper identifies two thresholds of Brachyury expression in NMPs that determine lineage potential and axis-forming ability in vitro.

Regulatory logic of neuronal differentiation in the Drosophila visual system

The paper identifies cell-type-specific enhancers and regulatory codes for neuronal differentiation in Drosophila using single-cell RNA and ATAC sequencing.

Alizarin red perturbs skeletal patterning and biomineralization via Catalase inhibition

This study shows Alizarin Red S causes skeletal and nervous system defects in embryos by inhibiting catalase, leading to increased reactive oxygen species.

Systematic differences in protein stability underlie species-specific developmental tempo

The paper identifies slower protein degradation in human cells compared to mice, linking protein stability differences to interspecies variations in developmental tempo.

Notch mediated lateral inhibition is shaped by morphological differences to reinforce bias toward signal-sending or receiving roles

The paper shows that morphological differences influence Notch-mediated lateral inhibition, biasing cells toward signal-sending or receiving roles during neuroblast selection.

Positional cues, not Notch, direct Neuroblast selection during early neurogenesis in the Drosophila embryo

The paper challenges the role of Notch in Neuroblast selection during early Drosophila neurogenesis, showing that positional cues pre-pattern Neuroblast fate and that Notch stabilizes rather than initiates fate decisions.