Developmental Biology and Gene Regulation

This study identifies two transcriptional cascades, BMP/JAK-STAT-zfh-2-bab1/B-H2/Lim1 and Notch-drm/bowl-bab1, that regulate cockroach leg regeneration.

This study shows that TBXT dose affects the timing of EMT in human gastruloids without compromising mesoderm differentiation.

This study identifies Foxl1 as a key driver of intestinal villification by regulating BMP, PDGFR, and planar cell polarity genes in telocyte progenitors.

The paper shows retinoic acid signaling is coupled to hindbrain segmentation in sea lamprey, suggesting this is a conserved vertebrate feature.

The paper investigates spatial and temporal patterns of Tip/Stalk specification during angiogenesis using a controlled model and mathematical analysis, revealing an order-disorder transition in NOTCH signaling.

This paper identifies genetic and developmental mechanisms underlying tail-length variation in deer mice, showing Hoxd13 expression differences and increased presomitic mesoderm in forest ecotypes.

This study examines contractile and protrusive cell behaviors at the zebrafish neural plate surface, revealing oscillatory contractile forces and medially polarized protrusions during convergence.

This study shows that Mllt11 is essential for proper trigeminal motor innervation of the masseter muscle by regulating ganglion cellular composition and NMJ formation.

This study shows Nodal signaling promotes embryonic axis elongation by inducing mesendoderm and suppressing BMP signaling in the dorsal mesendoderm.

This study identifies LET-381/FoxF and UNC-30/Pitx2 as key regulators of C. elegans mesodermal glia development and function, showing their role in motor behavior regulation.

The paper develops stochastic models to show that licensing and competition for niche access together regulate stem cell homeostasis and prevent extinction.

The paper describes thermal-induced body axis duplication in spider postembryos, linking anomalies to gene expression and cumulus formation disturbances.

The paper introduces Lineage Motif Analysis (LMA) to identify progenitor states by analyzing lineage trees, revealing spatial and temporal patterns in cell fate commitment across vertebrate development.

This study examines how halving Kruppel dosage affects even-skipped transcriptional dynamics in Drosophila embryos, revealing nonlinear relationships between TF dosage and developmental phenotypes through direct and indirect interactions.

The paper shows that BMP ligand diffuses from the niche and has opposing roles in maintaining stem cells and promoting differentiation of their daughter cells.

This study identifies miR-203 as a regulator of developmental timing and cell fate restriction during the totipotency to pluripotency transition in mouse embryos using genetically engineered models and single-cell RNA sequencing.

This paper shows hoxb genes regulate mesendoderm cell ingression timing by controlling cell surface fluctuations during zebrafish gastrulation.

The paper generates a molecular map of the avian trunk and tailbud using single-cell and spatial transcriptomics, identifying cell lineages and spatially restricted genes.

The paper identifies spatial subdomains in the Drosophila medulla and links patterning mechanisms to terminal selector expression in neuronal types.

The paper identifies the guinea pig as a new model for human preimplantation development, showing similarities in lineage formation and gene expression patterns.

The paper uses mass spectrometry to analyze the SMO tissue and finds increased energy metabolism and reactive oxygen species, suggesting a role in gastrulation.

The paper identifies Notch signaling as a regulator of temporal factor expression, controlling the timing of mushroom body neuroblast apoptosis in Drosophila.

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

The paper identifies TBX3 as a key transcription factor for establishing the antero-posterior axis polarity in mouse limb buds by repressing anterior genes and up-regulating posterior genes with HAND2.

The paper investigates how feedback control via BMP2-regulated apoptosis ensures precise organ size in Drosophila eyes by balancing proliferation and differentiation.

The paper identifies segmentally iterated expression patterns of FGF and BMP pathway genes in tardigrade embryos, suggesting roles in segmentation and dorsal-ventral patterning.

The paper identifies ZSWIM4-6 as a novel BMP signaling modulator in the sea anemone Nematostella vectensis through ChIP-Seq analysis of pSMAD1/5 target genes.

This study identifies Hkb's role in coordinating cell cycle regulation and morphogenesis during Drosophila salivary gland development, showing its impact on organ size and invagination.

The paper establishes the Mediterranean mussel as a new model organism for mollusk development by providing transcriptome data and experimental protocols.

The paper shows Smad4 is not required before implantation but is essential for epiblast morphogenesis after implantation in mice.