Developmental Biology and Gene Regulation

The paper shows how DNA motifs guide transcription factor cooperativity in embryonic face and limb mesenchyme, shaping cell identity and morphology.

This study shows glycolysis regulates the segmentation clock period in mouse embryos through a glycolysis-FBP-Wnt signaling axis, with FBP entraining Wnt oscillations.

The paper identifies gene expression changes and regulatory mechanisms underlying developmental divergence in the annelid Streblospio benedicti using RNAseq across ontogeny.

This study shows Notch signalling promotes mesodermal fate and HOX gene activation in human NMPs while inhibiting neural fate through a feedback loop with FGF.

This study generates 3D mammary organoids from eight eutherian mammals and a marsupial, revealing species-specific roles of ROCK in branching morphogenesis.

The paper identifies a gene regulatory network downstream of Pax3/7 in tunicate Ciona robusta ddNs, showing distinct transcription factors regulate different developmental branches.

The paper identifies epigenetic priming of lineage-specific fates in the mammalian epiblast, revealing early specification of endothelial and mesodermal lineages.

The paper investigates whether the segmentation clock and PSM morphogenesis exhibit developmental modularity in zebrafish, finding the clock is robust to morphogenetic variations.

This study shows that G9a is not essential for Prdm12's role in nociceptive neuron development, despite their interaction.

The paper identifies Mcf2lb as a regulator of rosette integrity during collective cell migration in zebrafish, showing its role in apical constriction and rosette organization.

This study shows that patterned apoptosis influences local growth and tissue shape in the Drosophila wing imaginal disc, challenging the assumption that cell death has minimal impact on organ size and morphology.

This study identifies and quantifies developmental canals in C. elegans embryogenesis that suppress noise and stabilize development, revealing how cell-level stochasticity affects phenotypic outcomes.

The paper uses machine learning to model BMP-driven cytoskeletal dynamics in Drosophila development and shows its conservation in human neuroectoderm morphogenesis.

The paper identifies Brat as a regulator that constrains regenerative growth in Drosophila, preventing patterning errors caused by excessive Myc expression.

This study shows that complete inactivation of the bicoid gene in Drosophila affects egg geometry, revealing an additional role beyond its known morphogen function.

The paper shows that TFAP2 paralogs regulate midfacial development via the ALX genetic pathway in mice and zebrafish.

The paper identifies 25 regulatory DNA segments conserved across bilaterian animals, including some in cnidaria, controlling developmental genes and revealing a conserved regulatory system since the Precambrian.

This study shows that Fgf signalling is required for epithelial remodelling and gill slit perforation in skate embryos, highlighting an ancestral role in vertebrate pharyngeal pouch development.

The paper shows that nonlinear spatial cue readout in C. elegans zygotes ensures robust asymmetric cell division despite input variation.

The paper investigates size compensation in Drosophila wing imaginal discs after ionizing radiation, finding that it occurs without increased proliferation or reliance on JNK, JAK/STAT, or Wg pathways.

The paper identifies Pp1-87B as a regulator of core PCP signaling by modulating Van Gogh subcellular localization and dephosphorylation in Drosophila wings.

The paper identifies a unique Hmgn2 variant in medaka fish that influences shape preference behavior through altered subnuclear localization and telencephalon development.

The paper studies BMP signalling dynamics in the developing neural tube, showing temporal relay mechanisms drive self-organised cell type patterns.

The paper shows that Midkine and Ptprz1b regulate Wnt/PCP pathway activity to coordinate midline formation in zebrafish hindbrain development.

This study shows Myosin XV negatively regulates signaling filopodia dynamics and promotes long-range Notch signaling during Drosophila sensory bristle patterning.

The paper uses scMultiome analysis in zebrafish to identify mixed-identity progenitors in the embryonic hindbrain and shows their subdivision into distinct rhombomeres.

The paper uses live imaging in zebrafish to show that Tbx6 expression waves, driven by Hes/Her genes, prefigure somite boundaries by arresting in boundary cells that later express Mesp.

The paper develops a bioelectric-genetic dynamical model to understand how spatial voltage patterns influence gene expression and brain development in Xenopus embryos, revealing mechanisms of information integration and plasticity.

The paper investigates rhythmic yolk contractions in goldfish eggs, finding they are intrinsic, independent of fertilization, and may influence dorsoventral patterning.