Cancer Cells and Metastasis

Unraveling the origin of Glucose mediated disparate proliferation dynamics of Cancer stem cells

The paper develops a mathematical model to explain how glucose regulates Nanog expression and drives differential proliferation in cancer stem cells through STAT3 and p53 dynamics.

AP-2γ is Required for Maintenance of Pluripotent Mammary Stem Cells

This study shows that AP-2γ is essential for maintaining pluripotent mammary stem cells and their ability to form mammary gland structures.

Simulation of multiple microenvironments shows a putative role of RPTPs on the control of Epithelial-to-Mesenchymal Transition.

The paper simulates microenvironments to show that RPTP activation by cell contacts can control EMT and promote MET under specific conditions.

Modeling the effects of EMT-immune dynamics on epithelial cancer progression

The paper models EMT-immune dynamics in epithelial cancer progression, identifying key factors that influence invasion-free survival and predicting new genes affecting cancer outcomes.

A Plausible Accelerating Function of Intermediate States in Cancer Metastasis

The paper investigates how intermediate states in EMT affect cancer metastasis by using a hidden Markov model to show that more intermediate states accelerate the process.

Phenotype-Based Probabilistic Analysis of Heterogeneous Responses to Cancer Drugs and Their Combination Efficacy

This paper introduces probabilistic phenotype metrics to assess drug efficacy and combination effectiveness by analyzing single-cell responses, showing they reduce bias and improve sensitivity to heterogeneity.

Mapping Lung Cancer Epithelial-Mesenchymal Transition States and Trajectories with Single-Cell Resolution

The paper maps EMT and MET states in lung cancer using single-cell resolution and a novel computational tool, showing differences in trajectories and providing a framework for clinical sample characterization.

Effect of feedback regulation on stem cell fractions in tissues and tumors: understanding chemoresistance in bladder cancer

The paper analyzes feedback regulation in bladder cancer to identify mechanisms causing cancer stem cell enrichment and chemoresistance.

Combinatorial perturbation analysis reveals divergent regulations of mesenchymal genes during epithelial-to-mesenchymal transition

The paper uses combinatorial perturbations to study EMT gene regulation, finding that mesenchymal genes show diverse dependencies on TGF-β and ZEB1, with functional differences in motility and cancer survival.

Testing the Gene Expression Classification of the EMT Spectrum

The paper uses computational methods to classify gene expression profiles into epithelial, hybrid E/M, and mesenchymal categories based on EMT dynamics and scoring metrics.

HERV-K HML-2 transcription in diverse cancers is related with cancer stem cell and epithelial-mesenchymal transition markers

The paper identifies HERV-K (HML-2) genes np9 and rec as correlated with cancer stem cell and EMT biomarkers, suggesting their role in cancer malignancy and cell state transitions.

Heterogeneity of normal human breast stem and progenitor cells as revealed by transcriptional profiling

The paper uses single-cell RNA sequencing to analyze ALDH+ and CD44+CD24- populations in normal human breast tissue, revealing heterogeneity and hybrid epithelial/mesenchymal cells with stemness and EMT features.

A Rational Drug Combination Design to Inhibit Epithelial-Mesenchymal Transition in a Three-Dimensional Microenvironment

The paper designs a drug combination to inhibit EMT in a 3D microenvironment by targeting histone deacetylases, SRC, and IKBK, showing effectiveness in a microfluidic model.