Cancer Cells and Metastasis

Mammary Epithelial Migration is EMT-Independent

This study shows mammary epithelial migration occurs without EMT, relying on preserved cell-cell adhesion and Snail1's role in directional movement.

Unlocking the role of SH3PXD2B in epithelial-to-mesenchymal transition driving Breast Cancer Lung Metastasis

This study identifies SH3PXD2B's role in promoting breast cancer lung metastasis through epithelial-to-mesenchymal transition, using RNA sequencing, functional experiments, and imaging.

Collective amoeboid dynamics drives colonization of drug-resistant ovarian cancer cells

This study shows drug-resistant ovarian cancer cells exhibit collective amoeboid dynamics that enhance their ability to colonize and invade tissues.

Breaking the cycle: How targeting CD44v6/MET signaling disrupts colorectal cancer cell plasticity

This study shows that targeting CD44v6/MET signaling disrupts colorectal cancer cell plasticity by repressing Lgr5+ cell reappearance and affecting YAP/TAZ signaling.

SOX2 drives fetal reprogramming and reversible dormancy in colorectal cancer

This paper shows SOX2 induces fetal reprogramming and reversible dormancy in colorectal cancer, promoting tumour progression and drug tolerance.

Adipocyte progenitors are primary contributors to the disrupted epithelial niche that is sustained following abrupt mammary gland involution

The paper identifies adipocyte progenitors as key contributors to a pathological epithelial niche after abrupt mammary gland involution, linked to postpartum breast cancer risk.

Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-Cell RNA Sequencing

This study identifies cancer stem cells in laryngeal squamous cell carcinoma using single-cell RNA sequencing and finds their molecular markers and therapeutic targets.

Cancer Stemness Online: A resource for investigating cancer stemness and associations with immune response

Cancer Stemness Online provides a resource for scoring cancer stemness and analyzing its associations with immune response and cancer hallmarks.

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform.

The paper develops a hypoxia-mimicking culture protocol and identifies a novel WT1 isoform linked to poor ovarian cancer survival.

A robust protocol for the systematic collection and expansion of cells from ER+ breast cancertumors and their matching tumor-adjacent tissues

This paper describes a protocol to isolate and expand autologous cells from ER+ breast tumors and their adjacent tissues for studying therapy resistance and tumor microenvironment interactions.

Heterotypic competition between cancer cells and hepatocytes generates heterogeneous context-dependent phenotypes

This study characterizes heterotypic competition between cancer cells and hepatocytes, showing varying competitiveness and its impact on metastatic phenotypes.

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments

The paper isolates and characterizes two colorectal cancer stem cell subtypes, showing they create distinct tumor microenvironments and unify existing CRC classifications.

AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data

This study uses AI to identify small molecules that induce breast cancer stem cell differentiation by training a deep neural network on gene expression data and validating results experimentally.

Cell-state transitions and frequency-dependent interactions among subpopulations together explain the dynamics of spontaneous epithelial-mesenchymal heterogeneity in breast cancer

The paper models the dynamics of E-M heterogeneity in breast cancer cells, finding that cell-state transitions, not growth differences, are essential for explaining observed population dynamics.

Identification and Pharmacological Targeting of Treatment-Resistant, Stem-like Breast Cancer Cells for Combination Therapy

The paper identifies treatment-resistant Cancer Stem-Like Cells in breast cancer using single-cell RNA sequencing and validates a drug combination to target them effectively.

A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticity

The paper analyzes the antagonistic roles of RKIP and BACH1 in cancer cell plasticity using transcriptomic data and a gene regulatory network model, showing their association with EMT, metabolic reprogramming, immune evasion, and clinical outcomes.

Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

The paper uses multi-modal transcriptomic data to show basal breast cancer exhibits hybrid epithelial/mesenchymal states and higher phenotypic heterogeneity compared to luminal breast cancer.

Stromal signals dominate gene expression signature scores that aim to describe cancer-intrinsic stemness or mesenchymality characteristics

The paper shows that stromal cells, particularly fibroblasts, dominate EMT-related gene expression signature scores in cancer, rather than tumor-intrinsic properties.

Pan-cancer analysis reveals embryonic and hematopoietic stem cell signatures to distinguish different cancer subtypes

The paper identifies four pan-cancer subtypes based on embryonic and hematopoietic stem cell signatures, showing distinct clinical and molecular features and prognostic implications.

Boolean modeling of mechanosensitive Epithelial to Mesenchymal Transition and its reversal

The paper builds a Boolean model of mechanosensitive EMT and its reversal, reproducing key phenotypes and offering testable predictions on EMT dynamics and biomechanical effects.

Bidirectional crosstalk between epithelial-mesenchymal plasticity and IFNγ-induced PD-L1 expression promotes tumor progression

The paper develops a mathematical model showing bidirectional crosstalk between EMT and IFNγ-induced PD-L1 expression, revealing how they influence tumor progression and immunotherapy resistance.

The drug-induced phenotypic landscape of colorectal cancer organoids

This study uses image-based profiling and multi-omics integration to identify morphological axes of variation in colorectal cancer organoids and link them to biological mechanisms and drug responses.

Epithelial-Mesenchymal Plasticity is regulated by inflammatory signalling networks coupled to cell morphology.

The paper shows that epithelial-mesenchymal plasticity is regulated by inflammatory signalling networks linked to cell morphology through changes in microtubule and nuclear organization.

Population dynamics of epithelial-mesenchymal heterogeneity in cancer cells

The paper models phenotypic switching in cancer cells to explain spontaneous epithelial-mesenchymal heterogeneity through stochastic SNAIL partitioning during cell division.

Heterogeneous, Population-Level Drug-Tolerant Persisters Exhibit Ion-Channel Remodeling and Ferroptosis Susceptibility

The paper identifies heterogeneous drug-tolerant persisters (DTPs) as population-level states with distinct division and death rates, showing increased ferroptosis susceptibility.

NRF2-dependent epigenetic regulation can promote the hybrid epithelial/mesenchymal phenotype

This study shows that NRF2-dependent epigenetic feedback can stabilize hybrid epithelial/mesenchymal states in EMT by affecting SNAIL, while other NRF2 links have less impact.

Transcriptomic-based quantification of the epithelial-hybrid-mesenchymal spectrum across biological contexts

The paper compares three transcriptomic metrics to quantify epithelial-mesenchymal plasticity across cancer and non-cancer contexts, finding high concordance and applicability beyond cancer.

Transcriptome analysis reveals high tumor heterogeneity with respect to re-activation of stemness and proliferation programs

The paper analyzes RNA-seq data from TCGA to assess stemness and proliferation gene expression across tumor types, finding high heterogeneity and questioning the use of stemness markers in cancer diagnostics.

A multi-tiered map of EMT defines major transition points and identifies vulnerabilities

The paper maps EMT transitions through multi-omic profiling, identifies key regulatory factors, and reveals discordance between molecular layers in human mammary epithelial cells.