Cellular Mechanics and Interactions

The paper simulates chiral actin bundle formation using helical motors and formins, finding that myosin braiding and formin synergy enhance compaction and coiling.

This study shows that liquid-like condensates containing both actin branching and bundling proteins can modulate the competition between these processes, leading to organized actin structures similar to those in migrating cells.

The paper proposes a theoretical framework for sarcomere assembly using sequential ordering data from Drosophila flight muscles, suggesting dynamic binding and tension-dependent feedback mechanisms.

This study shows fibroblast contractility is essential for inducing mammary epithelial branching through physical contact and signaling pathways involving YAP and ERK.

The paper investigates the role of PCP and Septins in organizing the actin cytoskeleton during Xenopus convergent extension.

This paper shows that increased extracellular matrix stiffness promotes vascular smooth muscle cell calcification by reducing nuclear actin monomer levels, which represses YAP-mediated osteogenic differentiation.

This study examines myosin's role in regulating actin cortex dynamics during bleb stabilization using mathematical modeling and microscopy data from Dictyostelium discoideum cells.

This paper presents a mechanical modelling framework to study endothelial permeability by simulating VE-cadherin bonds and their response to mechanical and chemical stimuli.

The paper describes a method to modulate lumen pressure in chicken embryos using a pressure sensor and water column.

This study evaluates how matrix stiffness affects autophagosome formation and apoptosis in embryonal rhabdomyosarcoma cells using GelMA hydrogels.

The paper measures cytoplasmic viscosity and elastic modulus in breast cancer cell lines to identify mechanical markers of metastatic potential, finding viscosity better discriminates between low and high metastatic cells.

The paper uses percolation theory to show how actin filaments form stress fibers through stochastic interactions, with assembly influenced by preexisting actin meshwork and disassembly independent of it.

This paper develops a theoretical framework to understand how motility drives glassy dynamics in epithelial monolayers, showing that confluency affects the effective persistence time-scale of active force.

This study investigates the mechanical properties of actin-vimentin composites using optical tweezers microrheology, revealing scale-dependent interactions that influence stress response and rheological behavior.

The paper shows that Piezo-dependent detection of matrix stiffness generates transient cells that repair basement membrane damage in Drosophila.

This study characterizes the mutation E334Q in gamma-actin, showing it affects interactions with myosin and ADF/cofilin proteins, potentially contributing to non-muscle actinopathy.

The paper investigates the role of core PCP mutations in Drosophila pupal wing morphogenesis and finds they do not affect tissue shape changes but influence fast mechanical responses.

This study shows TG2 binds more strongly to relaxed fibronectin fibers than stretched ones, revealing a mechano-regulated interaction mechanism.

The paper shows that mechanical tension in hippocampal neurons is essential for synaptic communication and firing in an in vitro network.

This study creates 3D collagen matrices with tumor-mimetic fiber alignment gradients to investigate their effect on cell migration.

The paper investigates how RhoA signaling pulses drive collective cell migration in zebrafish by stimulating actin polymerization and flow in protrusions.

The paper investigates how tail domains in formins regulate actin assembly through alternative splicing, showing that some tails inhibit processive elongation while others enhance it.

This study measures myosin cluster sizes in adherent cells and finds that cluster growth depends on ROCK activity, myosin self-affinity, and F-actin architecture.

This paper develops a mechanochemical model that explains vertebrate gastrulation morphologies by coupling actomyosin activity to tissue flow, showing how different patterns emerge from a uniform state.

SEM2 models multiscale mechanics in biological tissues using subcellular elements, demonstrating cell creep, migration, and proliferation in simulated platforms.

The paper investigates how elastic fibers in the mesentery influence tissue stiffness and enable buckling morphogenesis during intestinal looping in embryos.

This study examines how mechanical stimuli affect the phenotypic plasticity of hiPSC-derived vascular smooth muscle cells in 3D hydrogels, showing they adapt similarly to primary cells.

This study uses a 3D cell-based computational model to show that oriented cell divisions and repulsive mechanical interactions drive columnar cartilage formation in embryos.

The paper introduces a mouse model with fluorescently labeled collagen IV to study basement membrane dynamics during skin development and finds that BMs deform rather than lose adhesion during cell division.

The paper investigates how cyclic muscle contractions and actomyosin networks contribute to embryonic elongation in C. elegans using a theoretical model and finite elasticity analysis.