Lipid Membrane Structure and Behavior

Bilayer-forming lipids enhance archaeal monolayer membrane stability

This study shows that mixed diether and tetraether lipids improve archaeal membrane stability under thermal stress compared to pure lipid systems.

High-resolution cryo-EM structures of a protein pore reveal diverse roles of membrane lipids

This study uses cryo-EM to analyze actinoporin pores and shows how lipids interact with the protein, revealing their role in pore stability and structure.

Reversible tuning of membrane sterol levels by cyclodextrin in a dialysis setting

This paper demonstrates a method to reversibly adjust cholesterol levels in proteoliposomes using methyl-β-cyclodextrin in dialysis, showing reversible effects on membrane properties and protein behavior.

FlickerPrint: An Analysis Package for Measuring Interfacial Tension and Bending Rigidity of Biomolecular Condensates and Vesicles at Scale

FlickerPrint measures interfacial tension and bending rigidity of biomolecular condensates and vesicles from confocal images using flicker spectroscopy, enabling scalable population-level analysis.

Determination of Gaussian curvature modulus and spontaneous curvature via membrane buckling

This study measures Gaussian curvature modulus and spontaneous curvature by analyzing membrane buckling under compressive stress.

Shape transformation of vesicles induced by orientational arrangement of membrane proteins

The paper models how BAR family proteins induce shape transformations in vesicles by altering membrane curvature and orientation, revealing discontinuous shape transitions and hourglass-shaped necks.

Lipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates.

This study shows that lipid packing and cholesterol content influence condensate-membrane interactions, with increased packing reducing condensate affinity.

First moment of lateral pressure in lipid membrane: theoretical calculation

This paper derives an analytical expression for the first moment of lateral pressure in flat and bent lipid membranes and connects it to membrane elastic properties.

Molecular insight toward efficient & robust design of vesiculated protein nano-cages

This study investigates how protein nanocages induce membrane curvature through lipid sorting, providing insights into their design for efficient vesiculation.

On the coupling between membrane bending and stretching in lipid vesicles

The paper models the coupling between membrane bending and stretching in lipid vesicles, showing that thinning reduces bending energy and explains the lower limit of vesicle sizes.

All-atom simulations elucidate the molecular mechanismunderlying RNA-membrane interactions

This study uses all-atom simulations to reveal that guanine in RNA has the strongest interaction with membranes, while base pairing reduces membrane binding.

Alanine Scanning to Define Membrane Protein-Lipid Interaction Sites Using Native Mass Spectrometry

The paper identifies lipid binding sites on AqpZ using native mass spectrometry and molecular dynamics, revealing selectivity for cardiolipins at specific sites.

Membrane fusion-based drug delivery liposomes transiently modify the material properties of synthetic and biological membranes

This study demonstrates that cationic liposomes can fuse with membranes to deliver cargo efficiently but temporarily alter membrane properties.

Pore formation in complex biological membranes: torn between evolutionary needs

This study uses molecular dynamics simulations to investigate how lipid composition and properties influence membrane stability and pore formation in different biological membranes.

Modulation of Host Cell Membrane Biophysics Dynamics by Neospora caninum: A Study Using LAURDAN Fluorescence with Hyperspectral Imaging and Phasor Analysis

This study investigates how Neospora caninum alters host cell membrane order using LAURDAN fluorescence and hyperspectral imaging, revealing cholesterol redistribution and its impact on membrane fluidity.

Spectrally Resolved Single Molecule Orientation Imaging Reveals Direct Correspondence between Polarity and Order Experienced by Nile Red in Supported Lipid Bilayer Membrane

The paper uses spectrally resolved single molecule orientation imaging to show a direct link between polarity and order in lipid bilayers.

Biophysical modeling of membrane curvature generation and curvature sensing by the glycocalyx

This paper develops a biophysical model of the glycocalyx's role in generating and sensing membrane curvature, showing how glycocalyx properties influence membrane shape and curvature sensing.

Ist2, a protein involved in phosphatidylserine transport, is an ER lipid scramblase

This study identifies Ist2 as the first dedicated ER phospholipid scramblase in yeast and shows its role in ER membrane remodeling.

Lipid-directed covalent fluorescent labeling of plasma membranes for long-term imaging, barcoding and manipulation of cells

This paper introduces MemGraft, a covalent fluorescent labeling method for plasma membranes that enables long-term imaging, barcoding, and manipulation of cells without probe exchange.

Membrane partition and structural reorganization induced by anti-psychotics with distinct clinical profiles

This study compares how two antipsychotics, chlorpromazine and clozapine, partition into and modify lipid membranes, revealing differences in their membrane remodeling effects despite differing D2R antagonism strengths.

Spectral STED microscopy improves spectral sensitivity with polarity-sensitive probes and enables correlative measurements of membrane order and anomalous lipid diffusion

Lipopolysaccharides nanodiscs, a biomimetic platform to study bacterial surface.

This study develops LPS nanodiscs using SMA copolymers to investigate bacterial surface interactions and immune responses.

Peripheral membrane protein endophilin B1 probes, perturbs and permeabilizes lipid bilayers

This study presents the highest resolution cryo-EM structure of a BAR protein and shows endophilin B1 permeabilizes liposomes containing cardiolipin, proposing a new model for Bax-mediated cell death.

Peptide-induced hydration of lipid bilayers modulates packing pattern and conformations of hydrocarbon chains - a potential pathway for peptide translocation?

This study investigates how peptide-induced hydration changes lipid bilayer packing and hydrocarbon chain conformations, potentially facilitating peptide translocation across membranes.

MeTrEx: Membrane Trajectory Explorer

MeTrEx is a Python-based software for analyzing MD simulation data, focusing on ligand-membrane interactions, with tools for visualization, analysis, and comparative studies.

Is efficiency of protein incorporations governed by membrane properties? An α-synuclein and ceramide-1-phosphate investigation.

This study investigates how membrane properties influence protein-membrane interactions using α-synuclein and ceramide-1-phosphate.

Self-assembly of mycolic acid in water: monolayer or bilayer

This study uses MD simulations to analyze the self-assembly of mycolic acids in water, revealing structural properties and conformational changes in monolayers and mixtures, with quantitative agreement with experimental results.

Order disorder phase transitions in the plasma membrane of HeLa cells measured by fluorescent analysis of solvatochromic probes

This study measures order-disorder phase transitions in HeLa cell plasma membranes using fluorescent solvatochromic probes, finding reversible transitions influenced by cholesterol and temperature.

Visualizing sub-organellar lipid distribution using correlative light and electron microscopy

This paper introduces a correlative light and electron microscopy workflow to quantify lipid densities in membrane nanodomains and finds sphingomyelin partitions into specific endosomal structures.

Small-angle and quasi-elastic neutron scattering from polydisperse oligolamellar vesicles containing glycolipids

The paper uses neutron scattering techniques to study how glycolipids affect membrane mechanics and dynamics in polydisperse oligolamellar vesicles.