Lipid Membrane Structure and Behavior

Dynamic RhoA-Mediated Remodeling of Ordered Membrane Domains

This study identifies RhoA's role in modulating ordered membrane domains (OMDs) under stress, linking cytoskeletal changes to membrane mechanics and neuropathic pain.

Lipids modulate the organization of VDAC1, the gatekeeper of mitochondria

This study examines how mitochondrial outer membrane lipids affect VDAC1 assembly using atomic force microscopy and simulations, showing lipid regulation of VDAC organization.

Biological consequences of asymmetric hop diffusion in the cell membrane

This study uses numerical simulations and analytical theory to examine the physical requirements and biological consequences of asymmetric hop diffusion in cell membranes.

ACIDIC BICELLES ARE A SUITABLE MEMBRANE MIMIC FOR STRUCTURAL STUDIES OF THE LASSA VIRUS FUSION DOMAIN.

2Danalysis: A toolbox for analysis of lipid membranes and biopolymers in two-dimensional space

2Danalysis projects membrane and biopolymer properties to a 2D plane to analyze interactions and spatial correlations in simulations.

Revised diffusion law permits quantitative nanoscale characterization of membrane organization

The paper revises the diffusion law to quantify nanoscale membrane organization parameters using STED-FCS data, validating the Saffman-Delbruck assumption for lipid diffusion.

Membrane remodeling by the Bacterial Dynamin-like Protein (BDLP) from Nostoc punctiforme

This study investigates the membrane remodeling activities of BDLP from Nostoc punctiforme, showing it functions as a scaffold regulated by nucleotide binding rather than mediating fusion.

Free energy profiles of temozolomide crossing brain plasma membranes

This paper investigates how temozolomide crosses brain plasma membranes using molecular dynamics simulations, finding that it cannot cross by pure diffusion at normal body temperature but requires higher temperatures or assistance from cholesterol and cerebroside lipids.

Physics-based, data-driven cell-scale membrane simulations with HMFF

The paper introduces HMFF, a method integrating experimental data into membrane simulations, and applies it to various biological systems to enable multi-scale modeling.

Integrating experiments and simulations to unravel coacervate-membrane interactions: Insights into de-mixing and morphology modulation

This study combines experiments and simulations to investigate how coacervate-membrane interactions affect membrane morphology and fluidity, showing that anionic lipid content modulates these effects.

Exploring the kinetics and mechanism of phase separation in ternary lipid mixtures containing APP C99 using atomistic vs coarse-grained MD simulations

This study uses atomistic and coarse-grained MD simulations to investigate the kinetics and mechanism of phase separation in ternary lipid mixtures containing APP C99, identifying three distinct time regimes.

Lipid scrambling via TMEM16F mediates the formation and release of apoptotic vesicles

This study shows that TMEM16F-mediated lipid scrambling drives the formation and release of apoptotic-like vesicles without affecting cytosolic calcium or the cytoskeleton.

Saddle Curvature Association of nsP1 Facilitates the Replication Complex Assembly of Chikungunya Virus in Cells

This study shows that Chikungunya virus nsP1 preferentially binds to positively curved membranes, enabling saddle curvature association critical for replication complex assembly.

A minimalist model lipid system mimicking the biophysical properties of Escherichia coli membrane

This paper identifies three minimal lipid-only model systems that mimic the lipid composition and mechanical properties of E. coli inner membrane.

Computational modelling of toroidal membranes at division and fission sites

This study develops a computational model to simulate toroidal membranes and investigates their lipid properties and protein interactions during membrane fission processes.

Lipid Phase Behavior of the Curvature Region of Thylakoid Membranes of Spinacia oleracea. Isotropic Phase around the CURT1 Protein

The paper investigates the lipid phase behavior in thylakoid membrane curvature regions of spinach, revealing an isotropic non-bilayer phase enriched in monogalactosyldiacylglycerol.

Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

On the synergy between myelin proteins P0, MBP, and P2 in peripheral nerve major dense line formation

This study investigates how myelin proteins P0, MBP, and P2 interact with lipid membranes and each other, revealing both synergistic and competitive effects on membrane structure and stability.

Disruption of Plasma Membrane Lipid Asymmetry Alters Cellular Energetics

This study shows that disrupting plasma membrane lipid asymmetry in mammalian cells alters cellular energetics by shifting metabolism from anabolic to catabolic states.

Lipid flip flop regulates the shape of growing and dividing synthetic cells

This study shows that lipid flip flop regulates the shape of synthetic cells during growth and division by relaxing curvature stresses and enabling symmetric bud formation and scission.

Quantifying acyl chain interdigitation in simulated bilayers via direct transbilayer interactions

The paper introduces three new methods to quantify dynamic interdigitation in lipid bilayers using atomistic simulations, providing detailed insights into interleaflet interactions.

Glycocalyx-induced formation of membrane tubes

This paper develops a biophysical model to show glycocalyx can induce membrane tube formation through critical grafting density and polymer length, facilitated by actin forces and line tension.

Apolipoprotein interaction induces shape remodeling and lipid phase separation in giant unilamellar vesicles

This study investigates how ApoA-I interacts with lipid membranes to induce shape remodeling and lipid phase separation in GUVs, revealing key steps in lipoprotein assembly.

Effect of very long-chain lipids on the organization of biological membranes: A simulation perspective

The paper uses simulations to study how very long-chain lipids affect membrane organization, finding gel-like domains form and exclude ergosterol.

Signatures of glassy dynamics in highly ordered lipid bilayers with emergence of soft dynamic channels

This paper uses simulations to show that highly ordered lipid bilayers exhibit glass-like dynamics with soft fluid channels, which may facilitate molecular interactions.

Molecular Insights into Cholesterol Concentration Effects on Planar and Curved Lipid Bilayers for Liposomal Drug Delivery

This study uses molecular dynamics simulations to investigate how cholesterol affects planar and curved lipid bilayers, revealing geometry-dependent structural and dynamic changes.

Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers

The paper shows Ups1 preferentially binds to positively curved membranes, facilitating phosphatidic acid transfer between mitochondrial membranes.

Super-Resolution Diffusivity Mapping Reveals Spatial Correlations Between Lateral Mobility and Structural Heterogeneities on Cellular Membranes

This study introduces pc-SMdM, a super-resolution technique to map nanoscale diffusivity on cellular membranes, revealing clusters influenced by cholesterol and membrane structure.

Charge distribution and helical content tune the binding of septins amphipathic helix domain to lipid membranes

This study investigates how charge distribution and helical content of amphipathic helix domains affect septin binding to lipid membranes using simulations and experiments.

Effect of membrane composition on interaction and permeation of a mycobacterial siderophore

This study uses molecular dynamics simulations to show that iron-bound mycobactin flip-flops across mycobacterial membranes more slowly than generic lipids, with lipid composition affecting mobility.