Lipid Membrane Structure and Behavior

This study identifies structural determinants of P4B-ATPases through in silico analysis, revealing unique features that may underlie their monomeric phospholipid transport mechanism.

This study uses molecular dynamics simulations to show that partial oxidation of viral membrane lipids reduces SARS-CoV-2 spike protein anchoring stability, with full oxidation lowering the anchoring free energy by 23%.

This study uses photoswitchable lipids to control membrane remodeling in giant vesicles, showing how domain architecture influences light-induced mechanical responses.

The paper presents Martini 3 coarse-grained models for azobenzene-based photolipids and demonstrates their ability to accurately simulate membrane properties and photocontrol effects.

This study investigates how membrane neck size responds to pressure gradients, revealing a two-phase behavior with implications for nuclear envelope mechanics and synthetic membrane design.

The paper measures pressure-distance curves between lipid membranes in water, showing similar hydration repulsion between dissimilar phospholipid-glycolipid surfaces and glycolipid-glycolipid surfaces.

This study investigates how lipid composition affects liposome production yield and size distribution using the inverted emulsion method.

The paper introduces MAASTY, a copolymer for extracting membrane proteins into native nanodiscs, enabling high-resolution structural analysis with cryo-EM while preserving lipids.

The paper uses cryo-ET and a Surface Morphometrics pipeline to measure membrane thickness in organellar subcompartments, revealing variations and correlations with structural features.

The paper uses MD simulations to show that cardiolipin and a mitochondria-targeted peptide reduce electroporation risk by altering membrane capacitance and electrostatics under electrochemical stress.

The paper introduces a GPMV-imaging platform to study receptor binding and membrane fusion in live cells, showing how membrane composition affects fusion efficiency.

This study shows that PI(4,5)P2 transbilayer asymmetry facilitates FGF2 unconventional secretion by enabling membrane pore formation and GPC1-mediated translocation.

This study investigates how acylation of the RTX toxin MbxA enhances membrane disruption by interacting with cholesterol, showing acylation promotes pore formation but not initial membrane binding.

This study uses molecular dynamics simulations to show that lipid interactions drive the alignment and binding of p7 dimers during oligomer assembly.

This study investigates the structural dynamics of the HIV-1 gp41 membrane-interacting domain using molecular dynamics simulations and AI-based analysis, revealing diverse conformations of MPER-TMD and interactions with PIP2.

The paper shows that biomolecular condensates can induce local membrane potentials in Giant Unilamellar Vesicles, with effects influenced by salt concentration and ATP-to-poly-lysine ratios.

The paper shows that TORC2 regulates sterol redistribution to recover from membrane perturbation by small amphipathic molecules in yeast and mammalian cells.

This paper introduces a method using polymer-coated nanocellulose paper to efficiently assemble giant unilamellar vesicles under physiological conditions.

The paper investigates how membrane lipid homeostasis mechanisms adapt to species-specific lipid compositions in fission yeasts using lipidomics and transcriptomics.

This paper optimizes a coarse-grained lipid model for large-scale membrane protein simulations and demonstrates its application to study PIEZO-induced membrane deformation.

This study proposes a non-canonical lipid-mediated mechanism for eukaryotic membrane formation through molecular dynamics simulations.

This study uses cryo-EM to show how Vibrio cholerae Cytolysin induces membrane curvature and forms superassemblies during membrane rupture.

This study uses simulations to show how active filaments inside vesicles drive dynamic shape changes under osmotic stress, forming unstable structures like branched tubes and compartmentalized vesicles.

The paper develops a computational method to measure membrane thickness in cryo-electron tomograms, revealing systematic variations across organelles and supporting hydrophobic matching models.

The paper develops a peptide-based sensor to measure PI(4,5)P2 densities in membranes, showing mutation-specific changes in surface levels in cells with Ras mutations.

This study shows that lipid packing and membrane geometry jointly regulate septin localization in vitro and in cells.

This study shows that weakly adhered giant unilamellar vesicles can be deflated to small volumes, and uses shape analysis to determine mechanical parameters related to membrane behavior.

This paper describes a system using DNA origami to control directional membrane budding, mimicking virus assembly and producing DNA-shelled vesicles with applications in drug delivery and synthetic biology.

This paper introduces a peptide-based method to solubilize eukaryotic membrane proteins without detergents, enabling high-resolution structural studies.

This study investigates how cardiolipin affects SMA copolymer-mediated membrane solubilization by examining lateral lipid packing effects.