Traumatic Brain Injury Research

Frontoamygdala hyperconnectivity predicts autonomic dysregulation and persisting symptoms in sports-related concussion

This study finds that increased frontoamygdala connectivity after sports-related concussion correlates with autonomic dysregulation and persistent symptoms.

Explosive shock wave exposure leads to age-accelerated motor and sensory decline in C. elegans

This study shows that shock wave exposure in C. elegans causes age-accelerated motor and sensory decline, with structural neuronal damage and cytoskeletal issues.

Development of a modified weight-drop apparatus for closed-skull, repetitive mild traumatic brain injuries in a mouse model

This paper develops a closed-skull mouse model for repetitive mild traumatic brain injury using a custom weight-drop apparatus and evaluates behavioral and neuroinflammatory outcomes.

Individual trajectories for recovery of neocortical activity in disorders of consciousness

The paper uses biophysical simulations to study recovery of neocortical activity in disorders of consciousness, finding that excitatory corticothalamic synaptic strength loss correlates with cerebral glucose uptake and potential for recovery.

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

The paper identifies somatic genomic alterations in neurons from CTE patients, finding patterns similar to Alzheimer's disease and suggesting mechanisms beyond repetitive head impacts.

Regionally specific resting-state beta neural power predicts brain injury and symptom recovery in adolescents with concussion: a longitudinal study

Sex-differences in catecholamine transporter expression in the rodent prefrontal cortex following repetitive mild traumatic brain injury and methylphenidate treatment

This study examines how repetitive mild traumatic brain injury and methylphenidate treatment affect catecholamine transporter expression in male and female rats' prefrontal cortex.

Impact of > 24 h sustained wakefulness and subsequent recovery sleep on time-dependent changes in microRNA factors of individuals with post-acute phase mild traumatic brain injury

This study examines how prolonged wakefulness and recovery sleep affect microRNA expression in individuals with post-acute mild traumatic brain injury compared to controls.

Sex Differences in Plasma Levels of Endocannabinoids and Related Lipids Before and After acute and repeated mTBI: an exploratory study for plasma biomarkers for mTBI

This study examines sex differences in plasma endocannabinoid and lipid levels in a rat model of acute and repeated mTBI, finding greater changes in males and potential biomarker value for mTBI outcomes.

Progressive lifespan modifications in the corpus callosum following a single juvenile concussion in male mice monitored by diffusion MRI

This study tracks diffusion MRI changes in the corpus callosum of male mice after a single juvenile concussion across their lifespan, showing severity-dependent alterations in white matter integrity.

Inception: Simulating Personalized Long-Term Recovery in Disorders of Consciousness using Whole-Brain Computational Perturbations

Inception simulates long-term recovery in Disorders of Consciousness using whole-brain models and fMRI data, showing improved patient classification and potential for capturing pharmacological effects.

Spatially resolved transcriptomics reveals a unique disease signature and potential biomarkers for chronic traumatic encephalopathy

This study uses spatial transcriptomics to identify a 21-gene signature of CTE lesions, highlighting astrocytic activation and extracellular matrix remodeling as key features.

Cortical circuit principles predict patterns of trauma induced tauopathy in humans

The paper shows that cortical circuit principles predict the progression of tauopathy in CTE by aligning p-tau pathology with laminar connection patterns in human brains.

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

This study identifies plasma proteomic signatures associated with repetitive head impact exposure and CTE, linking them to immune, mitochondrial, and metabolic pathways and cognitive decline.

Volumetric and Diffusion Tensor Imaging biomarkers indicating long lasting post-concussion abnormalities in a youth pig model of mild Traumatic Brain Injury

This study uses a pig model to assess long-term post-concussion brain changes using volumetric and diffusion tensor imaging after mild traumatic brain injury.

Inhibition of p38 MAPK after repetitive mild TBI ameliorates immune signaling and behavioral deficits

This study investigates the effects of p38 MAPK inhibition on immune signaling and behavioral deficits after repetitive mild TBI in mice, finding sex-dependent benefits in inflammation and functional outcomes.

Personalized stimulation therapies for disorders of consciousness: A computational approach to inducing healthy-like brain activity based on neural field theory

This paper introduces a computational method to generate personalized brain stimulation signals for disorders of consciousness, showing in silico that it can induce healthy-like EEG power spectra.

Younger is Better But Only for Males: Social Behavioral Development Following Juvenile Traumatic Brain Injury to the Prefrontal Cortex

This study examines how age at injury and biological sex affect social behavior and frontal cortical plasticity after juvenile traumatic brain injury, finding age- and sex-dependent behavioral outcomes despite limited histological differences.

MILD TRAUMATIC BRAIN INJURY IMPAIRS EPISODIC MEMORY IN RATS

This study shows that mild traumatic brain injury impairs episodic memory in rats using a human-like task, without affecting non-episodic memory.

MILD TRAUMATIC BRAIN INJURY IMPAIRS SPATIAL WORKING MEMORY IN RATS

This study shows that mild traumatic brain injury impairs spatial working memory in rats using an animal model.

Comparison of Neural Tracking and Spectral Entropy in Patients with Disorders of Consciousness

This study compares neural tracking and spectral entropy in DoC patients to assess their brain responses to speech, finding correlations with clinical diagnosis and behavioral responsiveness.

Leukemia Inhibitory Factor as a late-stage treatment for delayed white matter loss in concussive head injury

This study shows that intranasal LIF treatment reduces delayed neurodegeneration and improves sensorimotor function after mild traumatic brain injury.

Evidence of Gait Impairment After mTBI in an Adolescent Pig Model

This study examines gait changes in adolescent pigs after mTBI, finding balance impairments and altered movement patterns similar to humans.

Bedside Assessment of Visual Tracking in Traumatic Brain Injury: Comparing Simple and Predictive Paradigms Using Multiple Oculomotor Markers

This study assesses oculomotor dysfunction in TBI patients using a novel bedside eye-tracking paradigm, finding widespread deficits correlated with functional recovery.

Interactions between mild traumatic brain injury and genetics perturb neuronal and glial pathways and networks relevant to learning and memory in ABCD study

The paper investigates the interaction between mild traumatic brain injury and genetics to identify pathway and network-level effects on learning and memory in adolescents using the ABCD cohort.

Exploring Comorbidity Networks in Mild Traumatic Brain Injury Subjects through Graph Theory: A Traumatic Brain Injury Model Systems Study

This study uses graph theory to analyze comorbidity networks in mild TBI patients, revealing age-dependent associations between psychiatric and non-psychiatric conditions.

Precision of the Integrated Cognitive Assessment for the assessment of neurocognitive performance in athletes

This study evaluates the precision of the Integrated Cognitive Assessment (ICA) test for cognitive function in athletes, finding high in-vivo precision and strong test-retest relationships.

LONGITUDINAL CHANGES IN WHITE MATTERMICROSTRUCTURAL STATUS FOLLOWING QUANTIFIEDHEAD-BALL IMPACTS IN SOCCER: A PRELIMINARY,PROSPECTIVE STUDY.

This study tracks white matter microstructural changes after soccer headers using MRI, finding correlations between impact magnitude and microstructural alterations.

Hepatocyte Growth Factor/MET Activator Rescues Working Memory Deficits After Repeated Mild Traumatic Brain Injury

This study shows that activating the HGF/MET system dose-dependently rescues working memory deficits after repeated mild traumatic brain injury.

Mild traumatic brain injury is associated with increased thalamic subregion volume in the subacute period following injury

This study finds increased thalamic subregion volume in mTBI patients compared to trauma controls in the subacute period using MRI and Bayesian analysis.