Traumatic Brain Injury Research

A unified central thalamus mechanism underlying diverse recoveries in disorders of consciousness

The paper identifies a unified central thalamus mechanism that explains diverse recovery outcomes in disorders of consciousness using electrophysiological data and machine learning.

AI Discovery of Mechanisms of Consciousness, Its Disorders, and Their Treatment

The paper introduces an AI framework to simulate and predict mechanisms of consciousness and disorders, validated with neurophysiological data.

Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity

This study investigates the effects of repetitive mild closed-head injury on synaptic density and BOLD-fMRI signal homogeneity in mice, finding decreased synapse density and increased regional homogeneity.

Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior

This study investigates how repetitive mild traumatic brain injury (mTBI) affects corticotropin-releasing factor (CRF) modulation of lateral habenula (LHb) excitability and motivated behavior in male and female mice, revealing sex-specific neurobehavioral effects.

Accelerated Aging after Traumatic Brain Injury: an ENIGMA Multi-Cohort Mega-Analysis

This study examines how brain-age differences (PAD) change over time after traumatic brain injury (TBI) using a large multi-cohort dataset.

Strain concentration drives the anatomical distribution of injury in acute and chronic traumatic brain injury

This study shows that strain concentration in specific brain regions, measured by MRE, correlates with injury sites in mTBI patients across different stages.

Effects of Concussion on the Relative Contributions of Sensorimotor Memories during Adaptation to Unpredictable Spring-Like Loads

This study investigates how concussion affects the use of implicit sensorimotor memories during adaptation to unpredictable loads, finding no group differences in memory contributions but suggesting procedural improvements for testing.

Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes

This study shows that repetitive head impacts in young athletes cause neuronal loss and neuroinflammation before CTE pathology, with specific cellular changes linked to disease progression.

Endocannabinoid-mediated rescue of somatosensory cortex activity, plasticity and related behaviors following an early in life concussion.

This study shows that an early-life concussion in mice increases somatosensory cortex activity and disrupts plasticity, but endocannabinoid system modulation can rescue these effects and improve behavior.

Age dictates brain functional connectivity and axonal integrity following repetitive mild traumatic brain injuries

This study examines how age affects brain connectivity and white matter integrity after repetitive mild traumatic brain injuries in mice using multimodal imaging techniques.

Disrupted maturation of white matter microstructure after concussion contributes to internalizing behavior problems in female children

This study finds that female children with concussions show greater post-injury internalizing and externalizing behavior problems, linked to disrupted white matter maturation.

Prediction of Post Traumatic Epilepsy using MRI-based Imaging Markers

This study uses MRI-based features and machine learning to predict post-traumatic epilepsy, achieving 0.78 AUC accuracy with a kernel support vector machine.

Concussion-related disruptions to hub connectivity in the default mode network are related to symptoms and cognition

The paper examines how concussion affects connectivity within and between brain networks, linking these changes to symptoms and cognitive performance in athletes.

Distinct spectral profiles of awake resting EEG in disorders of consciousness - the role of frequency and topography of oscillations

This study identifies distinct spectral profiles in resting EEG of PDOC patients using frequency and topography analysis, which correlate with neurobehavioral capacity and diagnosis.

Bypassing Striatal Learning Mechanisms Using Delayed Feedback to Circumvent Learning Deficits in TBI

This study investigates how delayed feedback affects learning in individuals with traumatic brain injury (TBI) and identifies brain regions associated with delayed feedback processing.

Mild blast TBI raises gamma connectivity, EEG power, and reduces GABA interneuron density

This study examines electrophysiological and histopathological changes in a rat model of mild blast-induced TBI, finding increased gamma connectivity, EEG power, and reduced GABA interneuron density.

Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion

This study examines electrophysiological changes in hippocampal neurons and their subtypes in a porcine model of concussion, finding altered properties in interneurons and hyperexcitability in pyramidal neurons.

Genome-wide Association Study of Traumatic Brain Injury in U.S. Military Veterans Enrolled in the VA Million Veteran Program

This study conducts a genome-wide association study (GWAS) of traumatic brain injury (TBI) in U.S. military veterans, identifying 15 genome-wide significant loci and showing genetic correlations with psychiatric traits.

Cognitive rehabilitation can improve brain injury-induced deficits in behavioral flexibility and impulsivity linked to impaired reward-feedback activity.

This study shows that cognitive rehabilitation improves behavioral flexibility and reduces impulsivity in rats with frontal TBI by enhancing orbitofrontal cortex activity and reward-feedback signaling.

Profiling the neuroimmune cascade in 3xTg mice exposed to successive mild traumatic brain injuries

This study examines how repeated mild traumatic brain injuries affect the brain in 3xTg mice, identifying sex-specific changes in gene expression and immune responses.

Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in traumatic disorders of consciousness

This study uses dynamic causal modelling of EEG to differentiate and predict consciousness states in traumatic disorders of consciousness, showing left frontoparietal connectivity differences between UWS and MCS+ patients.

Sub-Concussive Head Impacts From Heading Footballs Do Not Acutely Alter Brain Excitability As Compared to a Control Group

This study investigates whether sub-concussive head impacts from football headings alter brain excitability, finding no acute changes in corticomotor inhibition compared to a control group.

JZL184 increases anxiety-like behavior and does not reduce alcohol consumption in female rats after repeated mild traumatic brain injury.

This study shows that repeated mild traumatic brain injury increases alcohol consumption in female rats but not males, and JZL184 does not reduce alcohol consumption or alleviate anxiety-like behavior in either sex.

A single mild juvenile TBI in mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age in male mice

Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats

This study investigates sex and estrous cycle differences in mild TBI effects on anxiety and fear conditioning in rats, finding progesterone does not mitigate psychological symptoms.

Persistent Hypersomnia Following Repetitive Mild Experimental Traumatic Brain Injury: Roles of Chronic Stress and Sex Differences

This study investigates how prolonged stress and sex differences affect sleep-wake dysfunction in mice following repetitive mild traumatic brain injury.

Sex-stratified RNA-seq analysis reveals traumatic brain injury-induced transcriptional changes in the female hippocampus conducive to dementia

This study performs sex-stratified RNA-seq analysis of TBI-affected brain regions and identifies female-specific gene modules linked to dementia in TBI donors.

Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.

This study shows that inhibiting the integrated stress response (ISR) after concussive injury reverses cognitive deficits and aberrant cortical spine dynamics in mice.

Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury

This study examines sex differences in acute and chronic outcomes of repetitive blast mTBI in mice, finding similar and divergent patterns of cytokine, microbiome, and behavioral changes between sexes.

Resting-State Electroencephalography for Continuous, Passive Prediction of Coma Recovery After Acute Brain Injury

This paper develops a continuous resting-state EEG model to predict recovery from disorders of consciousness after acute brain injury, achieving high accuracy across multiple time horizons.