Memory and Neural Mechanisms

A neural substrate for resistance to change in the ventral hippocampus

The paper identifies a neural mechanism in the ventral hippocampus that stabilizes aversive beliefs during extinction learning by suppressing adaptive behavioral changes.

Learning temporal structure engages hippocampus and guides value-based behaviour

This study introduces a temporally structured olfactory task for mice to isolate relational structure from sensory cues and reward, showing that dopamine prediction errors and ventral hippocampal activity are linked to learned temporal structures.

Optogenetic stimulation of Purkinje cells in the cerebellar vermis disrupts innate freezing behaviors and is highly aversive

This study shows that optogenetic stimulation of cerebellar Purkinje cells disrupts freezing behaviors and increases aversion to predator-like stimuli.

Predicting individual differences of fear and cognitive learning and extinction

The paper predicts individual differences in fear and cognitive learning and extinction using multimodal neural connectivity patterns from a large dataset.

Contamination of Engram Coactivity Networks During Forgetting

This study shows that forgetting arises from reorganization of engram topology during consolidation and identifies engram core contamination as a network-level substrate for forgetting.

Universal Geometry of Compositional Construction in Prefrontal Cortex

This study shows rats use hierarchical composition to construct adaptive action sequences in an open-ended setting, with prefrontal neural representations following a universal geometric format.

Hippocampal conditioning code dominates and disrupts the place code

This study shows that during conditioning tasks, hippocampal activity shifts from spatial to temporally structured patterns, disrupting place coding in rats.

Mid-superior temporal sulcus encodes spatial context and behavioral state in freely moving macaques

This study shows that mid-superior temporal sulcus (mSTS) neurons in macaques encode spatial context and behavioral state during natural, unconstrained exploration.

Hippocampal and Midbrain Function in Superagers Relates to Memory for Novelty and Expectation Violation

This study investigates whether preserved hippocampal-midbrain function during novelty and expectation processing underlies superior memory in superagers compared to typical older adults.

Multiscale Mechanisms of Human Memory Modulation by Deep Brain Stimulation

This study investigates how different DBS frequencies and targets affect memory performance and identifies two dissociated mechanisms underlying these effects.

Specialized Computations for Generalized World Modelling in Medial Prefrontal Cortex

The paper investigates whether medial prefrontal cortex specialization is representational or computational, finding domain-invariant computations across spatial, social, and sequential domains.

Risk reshapes amygdala representation of choice

The paper shows that risk alters amygdala activity patterns during reward choice, leading to behavioral flexibility.

A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice

Memory and Hippocampal Responses to Event Boundaries are Modulated by Global Brain States

The paper investigates how global brain states modulate hippocampal responses to event boundaries and their relation to memory formation.

A scalable hippocampal code for flexible interval timing through persistent activity

The paper identifies a new hippocampal neuron subpopulation that supports flexible interval timing through persistent activity and temporal scaling.

Medial temporal lobe encodes cognitive maps of real-world social networks

The paper shows the entorhinal cortex encodes a cognitive map of social networks, enabling social navigation and information diffusion tracking.

Dual Engram Architecture within a Single Striatal Cell Type Distinctly Controls Alcohol Relapse and Extinction

The paper identifies two distinct engram ensembles within striatal medium spiny neurons that encode opposing memories for alcohol relapse and extinction.

Silent hippocampal engrams shape future memory processing

The paper shows that silent hippocampal engrams, which persist without memory recall, enhance the consolidation of new memories when reactivated.

Sleep-modulated disinhibition enables replay for memory consolidation, accelerated by ripples

The paper develops a biophysically detailed model to show that disinhibition drives memory consolidation during sleep, with replays and ripples playing key roles, and identifies therapeutic strategies for memory disorders.

Neuron-specific epigenetic repression of Cdk5 impairs hippocampal-dependent memory in male and female mice

The paper shows that reducing Cdk5 gene expression via epigenetic editing impairs memory in both male and female mice, highlighting sex-independent epigenetic regulation of hippocampal memory.

Challenges in Replay Detection by TDLM in Post-Encoding Resting State

The paper investigates replay detection using TDLM and MEG during post-learning resting states and finds no evidence of replay, suggesting methodological limitations in detecting low-density replay events.

A multiplexed striatal architecture for generalized spatial goal progress

This paper identifies a generalized spatial distance-to-goal signal in the nucleus accumbens that enables flexible goal-directed behavior across varying environments.

Stress-Enhanced Fear Learning (SEFL) is Associated with Enhanced Reactivation of Fear Engrams in Ventral but not Dorsal Dentate Gyrus

The paper investigates how stress affects fear memory engrams in the dorsal and ventral dentate gyrus using the SEFL model and FosTRAP2 mice, finding stress enhances reactivation in the caudal DG but not the rostral DG.

Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol for learning rate, retention and cognitive flexibility.

Memory consolidation and representational drift

This study develops a phenomenological model of memory consolidation that describes it as a brain-wide process involving representational drift and provides a functional interpretation of drift as a mechanism for improved memory retention.

Deletion of Cacna1c (CaV1.2) in D1-expressing cells elicits divergent sex-specific effects on aversive and spatial memories

This study investigates sex-specific effects of Cacna1c deletion in D1-expressing cells on fear and spatial memory in mice, revealing differential impacts on male and female behavior.

A theory of subicular function and generalized vector coding

The paper proposes a theory called Disco to explain subicular neural coding by framing activity as discontinuity signals in continuous experience.

Spatial and semantic memory reorganize a hippocampal long-axis gradient

This study investigates how spatial and semantic memory are organized along the hippocampus's long axis using fMRI and eye tracking, finding a combination of gradient and modular dynamics.

Spatial information transfer in recurrent place-cell networks depends on excitation-inhibition balance, neural-circuit heterogeneities, and trial-to-trial variability

The paper shows how excitation-inhibition balance, neural heterogeneities, and trial-to-trial variability jointly regulate spatial information transfer in recurrent place-cell networks.

Children exhibit greater persistence of motor learning-related patterns of hippocampal activity into post-task wake epochs

The paper shows children maintain hippocampal activity patterns related to motor learning longer during post-task rest than adults, suggesting enhanced reactivation supports their better memory consolidation.