Memory and Neural Mechanisms

Maximizing memory capacity in heterogeneous networks

This study estimates memory capacity in heterogeneous neural networks and finds that maximizing capacity requires correlations between inward connections and coding levels in brain-inspired models.

Ventral Hippocampus and NAc Core, but not Shell activity is required for well-learned instrumental memory destabilization

The paper investigates the role of ventral hippocampus and nucleus accumbens core and shell in destabilizing well-learned instrumental memory in rats, finding only the core is involved.

Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex

The paper investigates the direction of communication between the hippocampus and parahippocampal cortex using fMRI, finding that predictions are communicated from the hippocampus to deep layers of the parahippocampal cortex.

Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories

The paper mathematically proves that spatial periodicity in grid cell firing is the only solution to a neural sequence code for 2-D trajectories, explaining the hexagonal firing pattern and its functional role.

Error-driven changes in hippocampal representations accompany flexible re-learning

The paper shows error-driven drift in hippocampal representations enables flexible re-learning by allowing new associations to form while maintaining previous ones in synaptic weights.

Hippocampal sharp-wave ripples decrease during physical actions including consummatory behavior in immobile rodents

This study shows that hippocampal sharp-wave ripples (SWRs) decrease during physical actions and consummatory behavior in immobile rats, challenging the idea that SWRs are specific to consummation.

Hippocampal time cell dynamics evolve with learning to reflect cognitive demands

This study shows that hippocampal time cells adapt their dynamics during learning to reflect cognitive demands related to temporal context discrimination.

Mechanisms of alcohol influence on fear conditioning: a computational model

This paper introduces a computational model to explore how alcohol affects fear conditioning by simulating amygdala circuit changes and their impact on fear extinction.

Disturbed engram network caused by NPTXs downregulation underlies aging-related memory deficits

This study shows that NPTXs regulate engram network stability, and their downregulation in aging leads to memory deficits by causing hyperactivity in memory-related neuronal ensembles.

NaviGraph: A graph-based framework for multimodal analysis of spatial decision-making

NaviGraph is a graph-based framework for analyzing spatial decision-making by integrating multimodal data, revealing subtle recall impairments in ApoE4 mice.

Re-enacting steps supports human path integration consistent with motor-corrected grid cell drift

The paper shows that re-enacting movement patterns during memory retrieval improves distance estimation by correcting path integration errors in grid cells.

Practice Reshapes the Geometry and Dynamics of Task-tailored Representations

The paper shows that practice optimizes neural representational geometry to enhance task performance by stabilizing and aligning conjunctive neural states that abstract over non-critical task features.

Prefrontal encoding of an internal model for emotional inference

The paper shows that dmPFC neurons encode internal models of emotional associations, linking sensory stimuli with aversive events directly or indirectly.

A Unique Role for the Hippocampus in Cue Integration During Human Spatial Navigation

This study shows the hippocampus integrates spatial cues during navigation, with stronger positional coding when combining landmarks and self-motion cues, suggesting a role beyond simple spatial representation.

Coherent thalamic inputs organize head direction signal in the medial entorhinal cortex

The paper shows that coherent thalamic head direction signals from the anterodorsal nucleus influence medial entorhinal cortex coordination during wakefulness and sleep.

The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding

This study investigates how the estrous cycle affects hippocampal spine dynamics, dendritic processing, and spatial coding in female mice using in vivo imaging.

Cholinergic blockade reveals a role for human hippocampal theta in memory encoding but not retrieval

This study shows that cholinergic blockade disrupts hippocampal theta oscillations during memory encoding but not retrieval, suggesting theta reflects an encoding state rather than being required for retrieval.

Individual differences in fear memory expression engage distinct functional brain networks

The paper investigates individual differences in fear memory expression in zebrafish, identifying distinct behavioral groups and their associated brain networks.

Neural Circuit Underlying Individual differences in Visual Escape Habituation

The paper identifies two distinct visual escape behaviors and their neural pathways, revealing how the mediodorsal thalamus modulates arousal and defensive responses to repeated threats.

A top-down insular cortex circuit crucial for non-nociceptive fear learning

The paper identifies a neural circuit in the insular cortex crucial for non-nociceptive fear learning using a visual threat paradigm in mice.

Elusive scent of fear: no evidence of olfactory reversal conditioning in humans

This study investigates olfactory reversal conditioning in humans and finds no significant physiological or behavioral differences between conditioned and unconditioned odors.

Striatum supports fast learning but not memory recall

The paper shows that striatal activity is required for trial-to-trial learning improvements but not for memory recall.

Dopaminoceptive D1 and D2 neurons in ventral hippocampus arbitrate approach and avoidance in anxiety

This study identifies D1 and D2 dopamine receptor-expressing neurons in the mouse ventral hippocampus and shows they mediate opposing approach/avoidance behaviors during anxiety-related tasks.

Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes

The paper shows that hippocampal-entorhinal circuits and SMA represent action plans and their outcomes, with hippocampal activity scaling with outcome similarity and SMA responding to overlapping actions.

Instrumental Punishment Learning Enhances the Intrinsic Excitability of Basolateral Amygdala Neurons

This study shows that instrumental reward learning increases intrinsic excitability of BLA projection neurons, while punishment training maintains excitability and response-independent shocks reverse it.

MMP-2/9 inhibition modulates sharp wave abundance, inhibitory proteoglycan sulfation, and fear memory in juvenile zebrafish: relevance to affective disorders

This study shows MMP-2/9 inhibition affects SWR abundance, fear memory, and sociability in juvenile zebrafish, with implications for affective disorders.

Assessing the role of BNST GABA neurons in backward conditioned suppression

This study investigates how backward conditioned suppression is influenced by GABA-A receptor modulation and BNST GABA neurons in mice.

A sensitive period for the development of episodic-like memory in mice

This study shows that early-life experiences during a sensitive period influence the timing of episodic-like memory development in mice by modulating perineuronal net formation.

The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression

This study identifies a ventral CA2 region in the hippocampus that promotes social aggression but not social memory, distinguishing it from the dorsal CA2 region.

The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task.

The study shows that infralimbic cortex, but not prelimbic cortex, is required for resolving retroactive interference in a complex olfactory memory task.