Regulation of Appetite and Obesity

This study identifies dLSGLP-1R neurons and their GABAergic projections to the LHA as regulators of feeding behavior in mice, showing that inhibition of these pathways increases food intake.

This study compares gut hormone responses to feeding in older adults with low appetite versus healthy appetite and young adults, finding augmented anorexigenic responses in older adults with low appetite.

This study investigates tesofensine's effects on weight loss and neuronal mechanisms in mice and rats, finding it suppresses appetite and prevents weight rebound.

This study shows that metabolic sensing in AgRP neurons is essential for dopamine release in the nucleus accumbens in response to caloric solutions and influences sucrose preference under hunger.

This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.

This study identifies a novel neuronal population in the central amygdala that mediates nausea-induced feeding suppression through specific circuitry.

The paper identifies GABAergic neurons in the nucleus of the solitary tract (NTS) as a new modulator of feeding behavior and body weight by suppressing orexigenic AgRP/NPY neurons through projections to the hypothalamic arcuate nucleus.

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

The paper compares neuroanatomical, electrophysiological, and morphological properties of MCH cells coexpressing CART in male and female mice, finding sex-dependent differences in firing properties and dendritic structure.

This study shows that high-sucrose diets impair gut-brain communication by altering AgRP neuron activity, leading to increased palatable food intake.

This study shows that context-conditioned overconsumption in mice depends on reinforcer type, occurring in lean but not obese mice.

This study shows that female mice's neocortex is more resilient to food restriction than males, with males showing changes in energy-regulating pathways and ATP usage.

The paper identifies synergistic effects of multiple NTS neuron populations in suppressing food intake but shows they are not essential for the response to vertical sleeve gastrectomy.

This study shows AgRP neuron activity enhances flavor-nutrient associations in a sex-dependent manner and tracks these associations in real-time.

This study shows that ghrelin signaling in AgRP neurons integrates energy need with sensory cues to regulate AgRP activity and dopamine release in response to food.

This study shows that MC3R regulates AgRP neuron activation during fasting and cold exposure in a cell-autonomous manner, highlighting its role in energy homeostasis.

This study examines how ghrelin levels affect brain reward activation during touch, finding that higher ghrelin is linked to reduced reward value of touch.

This study identifies TNSST neurons in mice that modulate feeding behavior based on metabolic and reproductive states, with effects dependent on body mass and estrogen levels.

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

This study shows that RAI1 regulates body weight through hypothalamic BDNF neurons and neurotrophin signaling, and that targeting this pathway can delay obesity in SMS mice.

The paper identifies the xiphoid nucleus in the midline thalamus as a key region controlling cold-induced food seeking through neural activity and connectivity studies in mice.

This study investigates how hunger and peptides from the lateral hypothalamus influence social behavior through the insular cortex in rats.

This study shows that CNS sulfatide deficiency causes sex-dependent metabolic changes in aging, with females showing more severe metabolic disruption than males.

The paper identifies CeA neuron clusters and shows that ghrelin and fasting activate appetitive neurons involved in feeding behavior.

This study shows that GLP-1R+ neurons in the gustatory cortex regulate food intake in mice, with effects dependent on diet type.

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

This study investigates the relationship between ghrelin levels and neural responses to social and non-social rewards, finding no significant association with social rewards but a link to non-social rewards.

This study identifies two distinct GABAergic neural circuits in the hypothalamus that differentially regulate metabolic homeostasis and obesogenic feeding through specific GABAA receptor signaling pathways.

The paper shows that 2-DG rapidly activates specific neurons in the locus ceruleus and nucleus of solitary tract, as measured by phospho-ERK1/2 immunoreactivity, within 15 minutes of administration.

This study identifies the physiological roles of different enteroendocrine cell lineages in controlling feeding and gut motility using genetic and chemogenetic approaches.