Microtubule and mitosis dynamics

The paper investigates motor-driven microtubule network contraction and identifies a diffusive-like spread within the network, showing a conserved relationship between contraction rates and diffusion constants.

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

This study shows that Hedgehog signaling regulates mitotic spindle orientation in neural progenitors and iPSCs by affecting astral microtubules and transcriptional regulation of microtubule dynamics.

This study identifies CDR2 as a dynein adaptor recruited by kinectin to regulate ER sheet organization and shows its role in centrosomal clustering and ER sheet stacking.

This study identifies SSNA-1 as a centriole constituent required for structural integrity and bipolar spindle assembly in C. elegans.

The paper identifies two Msp300 isoforms essential for forming a perinuclear microtubule-organizing center in Drosophila adipocytes, with Msp300-PE being sufficient for its function.

The paper shows that kinetochores promote timely spindle bipolarization in mouse oocytes to reduce microtubule attachment errors and aneuploidy risk.

The paper shows that aneuploid cells are out-competed by normal cells, and cell interactions influence their elimination during development and disease.

The paper investigates how cytoplasmic density changes during cell differentiation and how this affects mitotic spindle architecture and scaling.

The paper identifies Clb4 as a factor preventing premature sister centromere separation in meiosis I of budding yeast, with effects dependent on genetic background.

This study identifies WDR2 as a regulator of KIN-G, showing it is essential for hook complex and Golgi biogenesis in Trypanosoma brucei, affecting flagellum inheritance and cytokinesis.

This study shows that microtubule dynamics depend on the conformation and stability of clustered protofilaments, linking GTP hydrolysis to polymerization states.

The paper shows that centromeric DNA sequences enhance force transmission through the inner kinetochore via the Okp1/Ame1 complex.

The paper shows CK2 inhibition shifts spindle morphology from meiotic to mitotic-like in Ciona and Xenopus, suggesting CK2 regulates RanGTP-driven microtubule nucleation during fertilization.

This study shows that palmitoylated importin α localizes NuMA to the cell cortex, regulating mitotic spindle orientation and preventing microcephaly in Xenopus laevis.

This study identifies how TRIM37 prevents ectopic spindle pole formation by recognizing peptide motifs in centrobin and undergoing substrate-dependent oligomerization.

The paper uses cryo-EM to visualize intermediate states of dynein activation pathway by analyzing structures of dynein and dynein-Lis1 bound to ATP.

The paper investigates how kinetochores facilitate the rapid assembly of the mitotic checkpoint complex (MCC) by co-orienting SAC catalysts in vitro.

The paper shows that phosphorylation of Stu2 by Cdc5 and dephosphorylation by PP2ACdc55 regulate its localization from kinetochores to microtubules during anaphase.

This study identifies the SUN1-ALLAN complex as critical for coordinating nuclear envelope remodeling and bipartite MTOC segregation during rapid mitosis in Plasmodium male gametogenesis.

This study shows that inhibiting the p38-MK2 pathway enhances the effectiveness of microtubule inhibitors in breast cancer cells while sparing normal cells.

This study shows that CEP152 binds to PLK4, enhancing its kinase activity and promoting centriole assembly by stabilizing PLK4 dimer formation and autophosphorylation.

This study identifies KIF2A's role in maintaining cytokinesis in mouse embryonic stem cells by stabilizing intercellular bridge microtubules, which prolongs cytokinesis to support pluripotency.

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

The paper constructs a minimal mathematical model to explain how AIR-1, ECT-2, and myosin dynamics drive polarization and cytokinesis in C. elegans, showing robust polarity establishment and cytokinesis prediction.

The paper shows that a phosphate-binding pocket on cyclin B influences CDK substrate phosphorylation and mitotic timing in budding yeast.

This paper reports cryo-EM structures of NEDD1 bound to the human γ-TuRC with and without CDK5RAP2, revealing how NEDD1 anchors the complex and orients its microtubule-binding domains.

This study identifies PHD1-dependent hydroxylation of RepoMan at P604, showing it regulates mitotic progression by modulating PP2A interaction and H3T3 phosphorylation.

The paper identifies a conserved NLS motif in TPX2 that regulates astral microtubule formation and spindle pole morphology in Xenopus egg extracts.