Microtubule and mitosis dynamics

This paper elucidates how TRIM37 regulates mesoscale MTOCs through a multi-step activation mechanism involving substrate recognition, oligomerization, and dimerization.

This study identifies metabolic vulnerabilities in aneuploid cancer cells through CRISPR screens and multi-omic analysis, revealing reliance on pyrimidine biosynthesis and sensitivity to DNA-damaging drugs.

This study uses live imaging to show mitotic errors and lineage plasticity in human embryos before implantation, revealing implications for aneuploidy mosaicism.

This study characterizes mitotic and centrosomal defects in a breast cancer continuum model, identifying increased chromosome segregation errors and centrosome abnormalities associated with disease progression.

This study shows that cytokinetic furrowing requires coordinated microtubule and Plk1 activity, with commitment to furrowing occurring ~6 min post-anaphase.

The paper identifies a regulatory helix in TRAK that mediates switching between kinesin- and dynein-driven mitochondrial transport in response to stress.

This study identifies early midzone formation events that stabilize nascent bipolar spindles by showing that γ-tubulin mutations disrupt interpolar microtubule formation, and that PRC1 homolog Ase1 can restore spindle stability in the mutant.

This study investigates how ERα regulates MCC components in breast cancer, showing that ERα promotes transcription of MAD2 and BUB1B, affecting mitotic outcomes and patient survival.

This paper identifies a maternally inherited Chromosomal Passenger Complex (CPC) component, Cdca9, essential for germ plasm ribonucleoparticle (gpRNP) aggregation in zebrafish embryos.

This study shows that in Candida albicans, dynein (Dyn1) and kinesin-5 (Kip1) work together to drive spindle elongation during anaphase, with Dyn1 compensating when Kip1 is absent.

The paper predicts eukaryotic flagellar beat patterns from molecular chemomechanical parameters using a nonlinear reaction-diffusion model, revealing new mechanisms for wave propagation and biophysical insights.

This study identifies a mechanism by which Centrocortin mRNA is co-translationally localized to centrosomes via dynein, microtubules, and a conserved dynein-binding motif.

This study shows PLK-1 phosphorylation regulates MEX-1 polarization in C. elegans zygotes, similar to its role in POS-1 segregation.

The paper identifies a novel dynamic site of Plk1 recruitment to the inner centromere during mitosis, regulated by Cdk1 and counteracted by Bub1/PP2A.

This study shows that APCCdh1-mediated degradation of Cdh1 is essential for proper meiotic chromosome segregation in S. cerevisiae.

This study shows that insulin signaling delays mitosis in C. elegans germline stem and progenitor cells in a non-autonomous manner, while caloric restriction affects mitosis through AMPK.

The paper introduces a computational method, IFTA, to analyze fluorescent speckle microscopy data, revealing new insights into cytoskeletal dynamics in mitotic spindles and actin convergence zones.

The paper identifies cell type-specific differences in cytokinesis regulation in C. elegans embryos using temperature-sensitive mutants.

This study investigates the molecular evolution of the kinetochore complex across primate and rodent species, finding adaptive evolution in many core components and highlighting the role of centromere features in driving protein evolution.

This study shows that microtubule dynamic instability is sensitive to specific viscogens, with glycerol having a distinct effect compared to other viscogens.

The paper shows that elastic mitotic tethers can generate backward forces on chromosomes even when spindle microtubules are inhibited.

The paper demonstrates that partial lysis of crane-fly spermatocytes during anaphase preserves tether function, allowing biochemical study of mitotic tethers.

The paper shows UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles without the motor's PH domain, enhancing transport and strengthening weak motor-lipid interactions.

The paper identifies a phosphate-binding pocket in cyclin B3 critical for XErp1/Emi2 degradation in meiosis I, preventing premature oocyte arrest.

This study shows that specific mitotic events drive cytoskeletal remodeling necessary for Left-Right Organizer development in zebrafish.

This study shows that transient lagging chromosomes in anaphase, caused by loss of WDR62 and ASPM, lead to impaired cell proliferation and primary microcephaly through Aurora-B-dependent activation of 53BP1 and p21.

This study shows that PAN2-PAN3 deadenylase activity is required for mitotic robustness under microtubule stress in yeast and human cells.

The paper shows that combining two Anillin mutants rescues cytokinesis defects, revealing uncoupled cytoskeletal roles mediated by Anillin's N- and C-termini.

The paper derives expressions for critical concentrations of dynamically unstable polymers, showing how nucleotide hydrolysis and spontaneous nucleation rates affect their assembly.

The paper investigates the role of CetZ1 in Haloferax volcanii morphogenesis, showing that its GTP-dependent self-association and specific structural features are critical for cell shape development.