Ion channel regulation and function

The paper models how changes in ion currents during zebrafish development affect primary motoneuron firing properties and locomotor activity.

This study uses cryo-EM to analyze HCN1 channel variants, revealing structural differences in cAMP sensitivity and auto-inhibition mechanisms between HCN1 and HCN2 isoforms.

This study examines how mutations in Kv2.1, a potassium channel linked to epileptic encephalopathy, affect channel clustering and neuronal excitability, finding impaired clustering but no change in excitability.

This study identifies Nckx30c as a Drosophila Na+/Ca2+ exchanger that regulates temperature-sensitive convulsions and age-related neurodegeneration through its role in Ca2+ homeostasis.

This study identifies a bi-directional binding site between the α2δ-1 subunit and the voltage-sensing domain I of calcium channels, revealing how it modulates activation kinetics.

The paper investigates how neuromodulators like serotonin and acetylcholine modulate the M-current in zebrafish primary motoneurons during development, showing age-dependent effects on firing properties.

This study shows that mammalian BK channels have higher unitary conductance, leading to more efficient calcium activation and stronger potassium currents compared to invertebrate channels.

This study identifies differences in HCN channel activity across mediodorsal thalamus subnuclei, linking these differences to distinct intrinsic oscillatory properties and cellular resonance.

The paper introduces a standardized ion channel model based on Hodgkin-Huxley formulation, demonstrating its ability to fit most voltage-gated models and enable parameter comparison and inference.

The paper traces the evolutionary origins of human voltage-gated K+ channels, identifying which were present in common ancestors and which were lost, and functionally characterizes the missing channels from other vertebrates.

The paper characterizes a Shaker potassium channel in a grasshopper neuron involved in visual object segmentation through electrophysiology and computational modeling.

The paper identifies the inactivation paths of Kv7.1 channels and shows how Ca2+-calmodulin prevents inactivation through allosteric interference.

This study identifies distinct electrophysiological properties of neurons in the mouse fasciola cinereum, revealing their unique intrinsic excitability and synaptic characteristics compared to neighboring hippocampal regions.

This study analyzes how model topology and stimulation protocols affect parameter accessibility in voltage-gated ion channel models using Sobol sensitivity analysis.

This study identifies the molecular mechanisms of GqPCR-mediated inhibition of TASK-1 and TASK-3 K2P channels and links their dysfunction to disease.

This study identifies MgPpIX as a potent and specific inhibitor of hNaV1.5, which suppresses cancer cell migration.

The paper proposes an allosteric model for electromechanical coupling in cardiac CNBD channels, explaining biphasic activation behaviors through voltage-sensor transitions and conformational coupling modes.

The paper investigates how CACNA1C variants affect single-cell dynamics in computational models of cortical pyramidal cells, identifying altered calcium regulation and dendritic retraction in Timothy Syndrome type II.

The paper investigates potassium flux through H+-sensitive KCN channels in cancer cells, linking it to pH reversal and oncogenic processes through differential gene expression analysis.

This study identifies the molecular mechanism of sodium-dependent fluoride export by FEX proteins using electrophysiology, cryo-EM, and simulations.

This study shows neurogranin binds to the L-type Ca2+ channel, facilitates calmodulin delivery, and enhances channel function through dynamic interactions.

This paper identifies a lipid plug in K2P6.1 channels that regulates their activity by occupying the central cavity and preventing ion permeation.

The paper identifies a specific Kv2/Kv6.4 channel subtype in spinal motor neurons localized at C-bouton synapses, showing dependence on Kv2 subunits for expression and clustering.

This study identifies a salt bridge in the bacterial ion channel SthK that functions as a temperature sensor, with lipid composition modulating its sensitivity to temperature changes.

The paper shows that clustering of voltage-gated sodium channels affects their biophysics, leading to different pharmacological responses and potential therapeutic implications.

This study identifies IQM-22110 as a selective KV4.3/KChIP3 modulator, showing it binds specifically to KV4.3/KChIP3 and not KV4.3/KChIP2 or KV4.3 alone.

The paper functionally characterizes six SCN9A missense variants associated with CIP, revealing that they cause complete loss-of-function through structural changes in the extracellular vestibule, ion selectivity filter, and N-terminus.

This study shows that Kir potassium channels regulate input excitability in parvalbumin interneurons similarly in human and mouse, inhibiting them during postsynaptic potentials.

This study identifies the ancient eukaryotic origins and conservation of NALCN/Cch1 channelosome subunits across animals, fungi, and apusomonads.

This study shows that photoperiod modulates SK channel function in dorsal raphe serotonin neurons through post-transcriptional mechanisms, linking seasonal cues to mood-related behaviors.