Esophageal Cancer Research and Treatment

CDK4/6 Inhibition Uncovers Subtype-Specific Vulnerabilities and Immune-Related Responses in Esophageal Squamous Cell Carcinoma.

This study evaluates palbociclib as a first-line therapy in eSCC, identifying response subtypes and showing immune activation through replication stress and DNA damage.

Community assembly modeling of microbial evolution within Barrett's esophagus and esophageal adenocarcinoma

The paper models microbial community assembly dynamics in Barrett's esophagus and esophageal adenocarcinoma, finding neutral dynamics in normal tissue and BE but not EAC, with H. pylori showing non-neutral behavior in BE non-cancer outcomes.

Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer

This study identifies CDK inhibitor-sensitive cells-of-origin in ESCC using single-cell trajectory analysis and drug repurposing, revealing key regulators and therapeutic vulnerabilities.

Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics

This study uses genetic barcoding and single-cell transcriptomics to trace lineage dynamics of esophageal preneoplastic cells, identifying a high-plasticity progenitor population and molecular markers for early detection of esophageal squamous cell cancer.

Single cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition

The paper uses single cell RNA-sequencing and genome-wide association study data to identify cell types and processes involved in Barrett's esophagus and esophageal adenocarcinoma risk.

Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis

This study shows that deleting epithelial Ikkβ in mice delays early esophageal carcinogenesis by reducing inflammation, T cell recruitment, and IFNγ/CXCL9 signaling.

Comparative analysis of protein expression between oesophageal adenocarcinoma and normal adjacent tissue

This study compares protein expression between oesophageal adenocarcinoma and normal adjacent tissue using proteomics to identify differentially expressed proteins and pathways.

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids

This study optimizes ADF-based medium for normal human esophageal organoids and models pathological changes using inflammatory and pharmacological stimuli.

Genomic copy number predicts oesophageal cancer years before transformation

This study shows genomic copy number changes can predict oesophageal cancer up to 10 years before diagnosis, enabling earlier treatment and reduced unnecessary monitoring.