Esophageal Cancer Research and Treatment

Polyclonal and clonal organoid models of Barrett oesophagus and oesophageal adenocarcinoma reveal heterogeneity in progression and therapy response

The paper generates organoid models of Barrett oesophagus and oesophageal adenocarcinoma to study disease progression and therapy response.

Transcriptomic Changes and Biomarkers in Barrett's Metaplasia, Dysplasia and Cancer

This study identifies transcriptomic changes and biomarkers across Barrett's metaplasia, dysplasia, and cancer to improve diagnostic accuracy for esophageal adenocarcinoma.

Single-cell profiling reveals MMP7-associated epithelial transition and immune-stromal remodeling in esophageal carcinogenesis

This study uses single-cell transcriptomics to identify MMP7-associated epithelial transitions and immune-stromal changes in esophageal carcinogenesis.

Mapping Functional Tumor Suppressor Networks in Esophageal Adenocarcinoma Using In Vivo CRISPR Screening and Perturb-sequencing

The paper identifies tumor suppressors and their functional roles in esophageal adenocarcinoma progression using CRISPR screening and Perturb-seq.

Dedifferentiation unlocks keratinocyte competence for metaplasia and tumorigenesis in the foregut

The paper shows that GATA4 drives metaplasia and tumorigenesis in esophageal squamous progenitors, but not keratinocytes, and that Hedgehog signaling expansion enhances this process.

Spatial tumor microenvironmental architecture of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma

This study identifies spatial tumor microenvironment features of chemoradiotherapy-resistant residual esophageal squamous cell carcinoma using spatial transcriptomics and single-cell analysis, revealing SPP1-associated macrophage programs and microvascular rarefaction as key factors.

CDK4/6 Inhibition Uncovers Subtype-Specific Vulnerabilities and Immune-Related Responses in Esophageal Squamous Cell Carcinoma.

This study evaluates palbociclib as a first-line therapy in eSCC, identifying response subtypes and showing immune activation through replication stress and DNA damage.

Spatially resolved transcriptomic and proteomic profiling reveals cell interaction programs that predict Barrett's esophagus progression

This study uses spatial transcriptomic and proteomic profiling to identify cell interaction patterns that predict progression of Barrett's esophagus.

Integration of proteogenomic analyses in esophageal squamous cell carcinoma

This study integrates proteogenomic analyses of esophageal squamous cell carcinoma to identify molecular subtypes and potential therapeutic strategies.

NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma

This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.

Community assembly modeling of microbial evolution within Barrett's esophagus and esophageal adenocarcinoma

The paper models microbial community assembly dynamics in Barrett's esophagus and esophageal adenocarcinoma, finding neutral dynamics in normal tissue and BE but not EAC, with H. pylori showing non-neutral behavior in BE non-cancer outcomes.

Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer

This study identifies CDK inhibitor-sensitive cells-of-origin in ESCC using single-cell trajectory analysis and drug repurposing, revealing key regulators and therapeutic vulnerabilities.

Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics

This study uses genetic barcoding and single-cell transcriptomics to trace lineage dynamics of esophageal preneoplastic cells, identifying a high-plasticity progenitor population and molecular markers for early detection of esophageal squamous cell cancer.

Colibactin-producing E. coli promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation

This study shows colibactin-producing E. coli promote GEAC carcinogenesis by increasing proliferation, DNA damage, and cancer pathways, while also inducing autophagy and differentiation.

Single-cell Genomic Copy Number Evolution Reveals Frequent Loss of the Y chromosome in Esophageal Adenocarcinoma

This study uses single-nucleus DNA and RNA sequencing to analyze LOY in EAC and find its association with tumor heterogeneity and immune evasion.

Single cell analysis of Barrett's esophagus and carcinoma reveals cell types conferring risk via genetic predisposition

The paper uses single cell RNA-sequencing and genome-wide association study data to identify cell types and processes involved in Barrett's esophagus and esophageal adenocarcinoma risk.

Epithelial Ikkβ deletion modulates immune responses and the IFNγ/CXCL9 axis during early esophageal carcinogenesis

This study shows that deleting epithelial Ikkβ in mice delays early esophageal carcinogenesis by reducing inflammation, T cell recruitment, and IFNγ/CXCL9 signaling.

Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer

This study identifies immune cell changes and gene expression patterns in Barrett's esophagus progression to cancer using spatial and multi-omic analyses.

Comparative analysis of protein expression between oesophageal adenocarcinoma and normal adjacent tissue

This study compares protein expression between oesophageal adenocarcinoma and normal adjacent tissue using proteomics to identify differentially expressed proteins and pathways.

Application of bidirectional Mendelian randomization to assess the relationship between the gut microbiome and esophageal cancer

This study uses bidirectional Mendelian randomization to examine the causal relationship between the gut microbiome and esophageal cancer, finding potential bidirectional effects but cautioning against overinterpretation due to biases.

Esophageal adenocarcinoma relapse after chemoradiation is dominated by a basal-like subtype

The paper identifies a basal-like subtype in esophageal adenocarcinoma associated with relapse after chemoradiation and poor survival.

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids

This study optimizes ADF-based medium for normal human esophageal organoids and models pathological changes using inflammatory and pharmacological stimuli.

The metaplastic precursor state to oesophageal adenocarcinoma represents reversion to a transient epithelial cell state in the developing oesophagus

The paper identifies a metaplastic precursor state in Barrett's oesophagus as a reversion to a fetal epithelial cell state, revealing HNF4A's role and GWAS SNPs in regulatory regions.

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

Clonal cell states link Barrett's esophagus and esophageal adenocarcinoma

The paper identifies clonal cell states in Barrett's esophagus and links them to esophageal adenocarcinoma progression through single-cell lineage tracing and transcriptional profiling.

Multi-omics integration in Esophageal Adenocarcinoma reveals therapeutic targets and EAC-specific regulation of protein abundances

The paper identifies GPA33 as an EAC-specific biomarker and reveals post-transcriptional regulation of protein expression in EAC through multi-omics integration.

Transcriptional landscapes and signaling pathways of chloroquine-treated Esophageal squamous cell carcinoma

The paper analyzes RNA-seq data from chloroquine-treated ESCC cells to identify transcriptional landscapes and signaling pathways involved in the treatment.

Extrachromosomal DNA in the cancerous transformation of Barrett's esophagus

The paper investigates the development and evolution of extrachromosomal DNA (ecDNA) in Barrett's esophagus patients progressing to esophageal adenocarcinoma, finding ecDNA is strongly associated with cancer progression and enriched for oncogenes and immunomodulatory genes.

Truncated Caveolin-3 Mutation In Familial Barretts Esophagus

The paper identifies a truncating CAV3 mutation in a family with Barrett's esophagus and links it to submucosal gland dysfunction and metaplasia.