Genetics, Aging, and Longevity in Model Organisms

Multi-generational silencing dynamics control cell aging

The paper tracks replicative aging in yeast cells and finds that intermittent heterochromatin silencing loss regulates lifespan, with Sir2 deacetylase playing a key role.

Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans

This study shows that mitochondrial sirtuins sir-2.2 and sir-2.3 in C. elegans extend lifespan when fed E. coli OP50 but not HT115, with diet-dependent changes in oxidative stress gene expression.

WIDE-SCALE COMPARATIVE ANALYSIS OF LONGEVITY GENES AND GENETIC INTERVENTIONS

This study compares longevity-associated genes across 205 species to determine their conservation and functional roles in aging.

Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish

This study shows that transferring gut bacteria from young African turquoise killifish to middle-aged ones extends their lifespan and delays aging-related behavioral decline.

Interplay between mitochondria and diet mediates pathogen and stress resistance in C. elegans

This study shows that a dietary vitamin B12 deficiency in C. elegans impairs mitochondrial function and stress resistance, which can be reversed by B12 supplementation.

Transcriptomic Description of an Endogenous Female State in C. elegans

The paper studies transcriptomic changes in C. elegans during the transition to an endogenous female state and finds that sperm loss drives some aging-related gene expression changes.

Systemic Activation Coordinates The Heat Shock Response Of The Insulin/IGF-1 Pathway In Caenorhabditis elegans

The paper shows that DAF-16 activation in head sensory neurons coordinates the heat shock response of the insulin/IGF-1 pathway in C. elegans, integrating local and systemic signals.

Neuronal Inhibition Of The Autophagy Nucleation Complex Extends Lifespan In Post-Reproductive C. elegans

The paper identifies genes regulating post-reproductive longevity in C. elegans, showing that inhibiting autophagy nucleation extends lifespan and healthspan via neuronal mechanisms.

Strehler-Mildvan correlation is a degenerate manifold of Gompertz fit

This paper shows that the Strehler-Mildvan correlation arises from fitting degeneracy in Gompertz models, not from biological homogeneity, and demonstrates this through analysis of C. elegans survival data.

AFF-1 fusogen can rejuvenate the regenerative potential of adult dendritic trees via self-fusion

The paper shows that AFF-1 fusogen or reduced IGF-1R/DAF-2 activity can restore dendritic regeneration in aged C. elegans.

Mating-induced Male Death and Pheromone Toxin-regulated Androstasis

This study investigates how mating affects male lifespan in Caenorhabditis species, identifying two mechanisms: germline-dependent lifespan reduction and pheromone-mediated toxicity.

Ageing, TOR and amino acid restriction: a cross-tissue transcriptional network connects GATA factors to Drosophila longevity

This paper identifies GATA transcription factors that regulate the effects of dietary restriction and TOR signaling on lifespan in Drosophila, showing tissue-specific manipulation can decouple longevity from fitness costs.