Parasites and Host Interactions

This study shows that malaria coinfection increases egg excretion and prolongs the persistence of an intestinal nematode in mice, mediated by reduced Th2 immunity.

This study screens compounds from the MMV Pathogen Box against a rodent hookworm model to identify anti-blood-feeding agents, finding five compounds effective in vitro and well-tolerated in vivo.

The paper compares miracidia from liver and intestine-derived eggs of Schistosoma mansoni, finding transcriptomic and behavioral differences that highlight the impact of egg source on experimental outcomes.

This review evaluates helminth-derived peptides' effects on inflammation in cellular models, finding they reduce pro-inflammatory cytokines and increase anti-inflammatory ones, suggesting therapeutic potential.

This study compares the transcriptomes of adult female and first-stage larvae of Dracunculus medinensis to identify molecular adaptations and potential diagnostic markers.

This study develops a system to track schistosome miracidia behavior and identifies a snail peptide that inhibits their penetration.

This study shows dietary fibre promotes chronic whipworm infection in mice through direct modulation of innate immunity, independent of the microbiome.

This study identifies Hp-FAR-2, a secreted fatty acid- and retinol-binding protein from H. polygyrus, which suppresses macrophage polarization by modulating both M1 and M2 markers, potentially aiding parasite persistence.

This study identifies metabolic and ribosomal dysregulation as key factors causing developmental arrest of Schistosoma japonicum in non-permissive rats.

This study shows schistosomiasis cercariae enhance transmission by swimming at the air-water interface, improving host-encounter efficiency through physics-based behavior.

This study shows that the human whipworm's host specificity is driven by the host microbiome, using a humanized-microbiota mouse model and metagenomic analysis.

This paper evaluates eDNA filtration and purification methods for detecting Schistosoma mansoni in lake water using qPCR, finding that certain filters and extraction protocols improve DNA yield and detection rates.

This study isolates and characterizes nonvesicular extracellular nanoparticles from Schistosoma mansoni eggs using tangential flow filtration, showing improved recovery and purity compared to differential ultracentrifugation.

This study shows that gut microbiota influences liver pathology caused by Schistosoma mansoni infection in mice, but not ileum inflammation.

This study examines how extreme flooding and seasonal changes affect the ecological niches of Biomphalaria snail species in Uganda, showing seasonal shifts in habitat suitability and species dominance.

This study shows that dermal gamma delta T cells migrate from the skin to the lungs during Nippostrongylus brasiliensis infection, balancing IL-17 and IFN-gamma responses to prevent lung damage.

This study uses genomic data to analyze A. lumbricoides transmission patterns and the impact of repeated drug treatment in a longitudinal cohort.

This study uses 2-D organoids to show that parasitic nematodes and their secreted products affect host gene expression differently depending on their location at the intestinal epithelium.

This study shows that the nematode Heligmosomoides bakeri can opportunistically feed on blood, leading to increased collagen gene expression and growth advantage, suggesting broader blood-feeding behavior in nematodes.

This study shows that intestinal helminth infection shifts DC2 development towards a regulatory phenotype to suppress anti-helminth immunity.

This study identifies two genomic regions associated with schistosome resistance in Biomphalaria sudanica snails using a genome-wide association study.

The paper uses population genomics and functional genetics to identify praziquantel resistance variants in Schistosoma mansoni.

The paper detects recent contamination in a laboratory Schistosoma mansoni population and shows how genetic drift causes divergence in parasite populations over time.

The paper uses nanopore sequencing to identify two genetically distinct Trichuris species in humans and non-human primates, revealing geographic patterns and highlighting a new diagnostic marker for resource-limited settings.

This study uses RNA-seq to analyze gene expression changes in mouse bladders infected with Schistosoma haematobium eggs, identifying differentially expressed host and parasite genes associated with inflammation and immune responses.

This study identifies and characterizes a new human-infecting Trichuris species, Trichuris incognita n. sp., which shows resistance to albendazole-ivermectin treatment and suggests species-level differences in drug response rather than resistance.

This study evaluates SNPs in β-tubulin genes of human soil-transmitted helminths to assess their association with benzimidazole resistance, finding no strong evidence for their role as resistance markers.

This study investigates the chromatin landscape and fitness effects of SmHP1 in Schistosoma mansoni, finding non-canonical HP1 enrichment and increased parasite fitness upon knock-down.

This study uses spatial transcriptomics to analyze gene expression changes in the small intestine of H. polygyrus-infected mice, identifying altered signaling pathways and cell interactions during infection.