Trypanosoma species research and implications

The paper analyzes transcriptome profiles of T.b. rhodesiense isolates from two Malawi foci, finding focus-specific gene expression patterns linked to disease severity and population structure.

This study shows that inhibiting bromodomain proteins in insect stage African trypanosomes causes transcriptome changes and disrupts VSG gene silencing, similar to developmental progression.

The paper evaluates gallinamide A and its analogs against Trypanosoma cruzi, finding that intramolecular π-π stacking interactions enhance potency by improving solubility and permeability.

The paper demonstrates that T. cruzi kinetoplast DNA minicircle sequences integrate into host genomes, and shows that multidrug treatment reduces their integration rate in mice.

The paper shows DRBD18 regulates RBP10 mRNA processing and export in Trypanosoma brucei by interacting with its 3-UTR, affecting mRNA stability and localization.

This study investigates the genomic basis of domestic colonization in Chagas disease vectors, finding that landscape elevation drives population structure and identifying genetic loci associated with adaptation to domestic environments.

The paper identifies and characterizes the membrane-associated kinome of Trypanosoma brucei, revealing unique structural features and subcellular localization compared to other eukaryotes.

This study identifies CFB2 as an essential RNA-binding protein that stabilizes VSG mRNA in trypanosomes, crucial for antigenic variation and cell survival.

This study shows that the smORF-containing gene mlpt is essential for moulting in Rhodnius prolixus and inhibits Trypanosoma cruzi metacyclogenesis, impacting Chagas disease transmission.

The paper performs a genome-wide RNAi screen in Trypanosoma brucei to identify cell cycle regulators, identifying hundreds of proteins involved in different stages of the cell cycle and providing functional genomic insights.

The paper identifies a novel RNA-binding protein complex in Trypanosoma brucei and shows its role in mRNA translation and quality control.

This study shows that PUF3 is not essential for Trypanosoma brucei growth or differentiation in vitro but may have a role in the invertebrate host or gene expression regulation.

This paper introduces a cost-effective method for analyzing pathogen genetic variation directly from host/vector material, demonstrating its ability to distinguish parasite strains and correlate genetic with geographic distances.

The paper identifies PBP1-associated proteins in Trypanosoma brucei, showing their roles in mRNA stabilization and translation initiation complex recruitment.

The paper uses a T. brucei ORFeome to create a Gain-of-Function library and identifies novel genes linked to melarsoprol resistance.

The paper presents a comparative genomic analysis of six Glossina species, identifying genetic features related to their unique biology and vectorial capacity.

The paper analyzes genetic structure and sodium channel gene mutations in Triatoma infestans populations to understand pyrethroid insecticide resistance and gene flow patterns in Bolivia.

This study uses Nanopore sequencing to improve genome assembly of Trypanosoma cruzi, increasing contiguity and assembly size by ~16 Mb.

The paper uses nascent DNA proteomics to identify proteins involved in DNA replication fork dynamics in Trypanosoma brucei, revealing essential and unknown replication factors.

This study shows that ATR kinase in Trypanosoma brucei is essential for DNA damage signaling and controls monoallelic VSG expression during antigenic variation.

The paper identifies a post-transcriptional regulatory element in the 3UTR of a lifecycle stage-regulated gene in Trypanosoma brucei that mediates glucose-responsive translational control.

The paper identifies genetic factors and immune mechanisms associated with symptom severity in human African trypanosomiasis using transcriptome analysis and an animal model.