Neurological disorders and treatments

Cholinergic Transmission in an Inducible Transgenic Mouse Model of Paroxysmal Dystonia

The paper investigates cholinergic transmission in a mouse model of dystonia, finding that D2R-mediated paradoxical excitation of cholinergic interneurons is reversed by caffeine, suggesting a role in movement regulation.

Modulation of pedunculopontine input to the basal ganglia relieves motor symptoms in Parkinsonian mice

This study identifies a neural circuit involving the pedunculopontine nucleus that modulates movement and gait in Parkinsonian mice, showing that targeting this circuit can alleviate motor symptoms.

Structural Plasticity of GABAergic Pallidothalamic Terminals in MPTP-treated Parkinsonian Monkeys: A 3D Electron Microscopic Analysis

This study uses 3D electron microscopy to show structural changes in GABAergic pallidothalamic terminals in MPTP-treated monkeys, revealing increased terminal volume, synapse surface area, and mitochondrial volume in specific thalamic nuclei.

Multi-night naturalistic cortico-basal recordings reveal mechanisms of NREM slow wave suppression and spontaneous awakenings in Parkinson's disease

This study uses multi-night recordings to show that Parkinson's disease affects NREM sleep by altering cortico-basal slow wave activity and subcortical beta power, with DBS enhancing these changes and predicting spontaneous awakenings.

Spontaneous pain dynamics characterized by stochasticity in awake human LFP with chronic pain

This study analyzes spontaneous pain dynamics in chronic pain patients using high-temporal-resolution LFP signals and identifies associations between theta/alpha and gamma band events with pain and opioid effects.

Cross-species modeling and enhancement of cognitive control with striatal brain stimulation

The paper develops an animal model of human brain stimulation therapy, showing it enhances cognitive control by improving the brain's ability to process conflicting evidence.

Depression Attenuates Caudate and Dorsolateral Prefrontal Cortex Alpha and Beta Power Response to Reward

This study investigates how depression affects neural oscillations in the caudate and DLPFC during reward feedback, finding reduced alpha and beta power responses in depressed individuals.

Behavioral changes preceded by subthalamic nucleus alterations in a progressive macaque model of Parkinson's disease.

This study shows that STN dysfunction precedes motor symptoms in a macaque PD model and suggests targeted stimulation strategies for both motor and non-motor symptoms.

Prefrontal network engagement by deep brain stimulation in limbic hubs

This study investigates the neurophysiological effects of deep brain stimulation (DBS) on prefrontal networks in limbic hubs, showing differential modulation of gamma oscillations and subject-specific responses.

Deep brain stimulation device-specific artefacts in MEG recordings

This study compares DBS artefacts in MEG recordings using different DBS devices and cleaning methods, finding device-specific differences and potential spectral artefacts after cleaning.

The effect of deep brain stimulation on cortico-subcortical networks in Parkinson's disease patients with freezing of gait: Exhaustive exploration of a basic model

This paper uses a computational framework to explore how combined deep brain stimulation of the STN and SNr affects cortico-subcortical networks in Parkinson's disease patients with freezing of gait.

The impact of Parkinson's disease on striatal network connectivity and cortico-striatal drive: an in-silico study

This in-silico study predicts how Parkinson's disease alters striatal network connectivity and glutamatergic drive to striatal projection neurons.

Synaptic changes in pallidostriatal circuits observed in parkinsonian model triggers abnormal beta synchrony with accurate spatio-temporal properties across the basal ganglia

This paper models abnormal beta oscillations in Parkinson's disease by simulating basal ganglia circuits constrained by experimental data, showing that pallidostriatal loops drive mid-beta oscillations.

The somato-cognitive action network links diverse neuromodulatory targets for Parkinson's disease

This study identifies the somato-cognitive action network (SCAN) as a key pathway in Parkinson's disease, showing its dysfunction and link to neuromodulatory treatments.

Differential Contribution of Sensorimotor Cortex and Subthalamic Nucleus to Unimanual and Bimanual Hand Movements

The paper investigates how sensorimotor cortex and subthalamic nucleus encode unimanual and bimanual hand movements, finding that STN encodes movements for both hands and is context-sensitive, while SMC is contralaterally biased and context-insensitive.

Uncovering network mechanism underlying thalamic deep brain stimulation

The paper investigates the network mechanisms underlying thalamic deep brain stimulation and identifies key features of spiking activity in response to high-frequency stimulation.

SUBTHALAMIC HIGH-FREQUENCY DEEP BRAIN STIMULATION REDUCES ADDICTION-LIKE ALCOHOL USE AND SUPPRESSES THE OVERCONSUMPTION INDUCED BY THE PEER S PRESENCE

This study examines how peer presence affects alcohol consumption in rats and evaluates the impact of subthalamic nucleus deep brain stimulation on this behavior.

Modeling synaptic integration of bursty and beta oscillatory inputs in ventromedial motor thalamic neurons in normal and parkinsonian states

The paper models synaptic integration in ventromedial motor thalamocortical neurons under normal and dopamine-depleted conditions, finding increased firing rates and altered responses to inhibitory inputs in dopamine-depleted states.

Into the deep: The subthalamic and para-subthalamic nuclei in behavioral avoidance

This study investigates the role of the subthalamic nucleus (STN) and its adjacent para-STN in behavioral avoidance using optogenetics and electrophysiology in mice.

Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson's disease

This study investigates how dopamine and deep brain stimulation (DBS) affect neural dynamics in Parkinson's disease by measuring motor intention latency and oscillatory communication patterns.

Combining Magnetoencephalography with Telemetric Streaming of Intracranial Recordings and Deep Brain Stimulation - a Feasibility Study

This study tests the compatibility of telemetric LFP streaming with MEG in DBS patients, finding that Percept PC with SenSight leads generates limited interference and OPM systems are more resilient to artefacts.

Selective activation of subthalamic nucleus output quantitatively scales movements

This study selectively stimulates STN projection neurons in mice and shows that STN output directly controls movement parameters with high precision.

Non-linear input-output relationships in the subthalamic nucleus of Parkinson's patients

The paper examines non-linear input-output relationships in the subthalamic nucleus of Parkinson's patients by analyzing local field potentials and spiking activity.

Chronic deep brain stimulation of the human nucleus accumbens region disrupts the stability of inter-temporal preferences.

This study shows that chronic deep brain stimulation of the nucleus accumbens disrupts long-term stability of inter-temporal preferences in OCD patients.

Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson's Disease: Model Based Predictions and Validation in Three Human Subjects

This study develops a model to predict cortical gamma oscillation entrainment to DBS in Parkinson's patients and validates it in three subjects.

Disrupted sleep in dystonia depends on cerebellar function but not motor symptoms in mice

This study investigates how cerebellar dysfunction affects sleep in dystonia mice, finding disrupted sleep patterns independent of motor symptoms.

Robust Adaptive Deep Brain Stimulation Control of Non-Stationary Cortex-Basal Ganglia-Thalamus Network Models in Parkinson's Disease

This paper develops a robust adaptive closed-loop DBS method for Parkinson's disease that outperforms existing methods in regulating neural dynamics under nonlinear and non-stationary conditions.

Basal Ganglia Stimulation Ameliorates Schizophrenia Exploration Anomalies

This study shows that GPe stimulation restores exploration-exploitation balance disrupted by PCP in NHPs, suggesting potential therapeutic benefits for schizophrenia.

Opposing functions of glutamatergic inputs between the globus pallidus external segment and substantia nigra pars reticulata

This study investigates the opposing roles of glutamatergic inputs to the GPe and SNr in basal ganglia function using behavioral tasks in monkeys.

Inferring Cognitive State Underlying Conflict Choices in Verbal Stroop Task Using Heterogeneous Input Discriminative-Generative Decoder Model

The paper introduces a model to infer cognitive states during conflict processing in a Stroop task using neural and behavioral data from Parkinson's patients.