Neurological disorders and treatments

Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensemble.

The paper identifies multiple spatially discrete beta ensembles in parkinsonian cortico-basal ganglia networks, showing they form functionally connected clusters of neurons.

Interrogating basal ganglia circuit function in Parkinson's disease and dystonia

The paper examines differences in GPi neuronal activity and synaptic plasticity in Parkinson's disease and dystonia, finding distinct patterns of oscillatory activity and plasticity associated with each disorder.

Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor Phenotypes

Knocking out Gnal in the striatum of mice leads to dystonia-like motor symptoms and increased excitability in striatal spiny projection neurons.

Treatment Efficacy of Theophylline in ADYC5 Dyskinesia: A Retrospective Case Series Study

This study evaluates theophylline's efficacy in treating ADCY5-related dyskinesia, finding significant symptom improvement in 92% of patients with notable adverse effects.

Drumming Performance and Underlying Muscle Activities in a Professional Rock Drummer with Lower-Limb Dystonia: A Case Study

This case study examines how lower-limb dystonia affects a professional drummer's performance and muscle activity during specific drumming tasks.

Evoked resonant neural activity outperforms spectral markers in decoding sleep from the subthalamic nucleus

This study compares evoked resonant neural activity (ERNA) to spectral markers in decoding sleep stages from subthalamic nucleus recordings in Parkinson's patients, finding ERNA provides better classification accuracy.

Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation

This study optimises intrastriatal deep brain stimulation by using a biophysical network model to align activity patterns with healthy states.

Spike-wave discharges during low-current thalamic deep brain stimulation in mice

This study reports that CT-DBS in awake mice can induce SWDs at low currents during titration, highlighting the need for EEG monitoring.

Movement-related increases in subthalamic activity optimize locomotion

This study shows that movement-related increases in subthalamic nucleus activity enhance locomotion in mice, with specific effects observed in disease models.

Excessive Firing of Dyskinesia-Associated Striatal Direct Pathway Neurons is Gated By Dopamine and Excitatory Synaptic Input

The paper investigates how levodopa-induced dyskinesia is linked to increased activity in specific striatal direct pathway medium spiny neurons, driven by dopamine and excitatory inputs.

Unexpected contributions of striatal projection neurons coexpressing dopamine D1 and D2 receptors in balancing motor control

The paper identifies D1/D2 coexpressing striatal projection neurons as critical for modulating motor function through interactions with D1- and D2-SPNs.

Ventrointermediate thalamic stimulation improves motor learning in humans

This study shows that VIM-DBS enhances motor learning for fixed sequential finger movements but not for random sequences, indicating its role in thalamo-cortical motor learning.

Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation

This study uses optogenetic fMRI to identify neural circuits affected by subthalamic nucleus deep brain stimulation in Parkinson's disease, finding that GP and CPu activity mediate therapeutic effects.

Generators of the frequency-following response in the subthalamic nucleus: implications for non-invasive deep brain stimulation

The paper identifies a frequency-following response in the subthalamic nucleus using auditory stimuli, suggesting potential for non-invasive deep brain stimulation.

Evoked Resonant Neural Activity Long-Term Dynamics can be Reproduced by a Computational Model with Vesicle Depletion

The paper presents a computational model that reproduces the long-term dynamics of evoked resonant neural activity (ERNA) using vesicle depletion as the key mechanism.

Convergence of inputs from the basal ganglia with layer 5 of motor cortex and cerebellum in mouse motor thalamus

This study investigates the convergence of inputs from the basal ganglia, motor cortex, and cerebellum in the mouse motor thalamus using optogenetics and viral labeling.

A frameshift mutation in the murine Prkra gene causes dystonia and exhibits abnormal cerebellar development and reduced eIF2α phosphorylation.

This study investigates the effects of a Prkra frameshift mutation in mice, showing reduced eIF2 phosphorylation and cerebellar abnormalities linked to dystonia.

Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems

The paper identifies striosomal pathways that target substantia nigra dopamine neurons, with opposite effects on movement compared to canonical pathways.

Targeting DBS to the centrolateral thalamic nucleus improves movement in a lesion-based model of acquired cerebellar dystonia in mice

This study shows that targeting deep brain stimulation to the centrolateral thalamic nucleus reduces dystonia in a mouse model caused by cerebellar outflow tract lesions.

Quantifying Harmony between Direct and Indirect Pathways in The Basal Ganglia; Healthy and Parkinsonian States

The paper quantifies the balance between direct and indirect pathways in the basal ganglia in healthy and Parkinsonian states using a competition degree metric.

eIF2α phosphorylation evokes dystonia-like movements with D2-receptor and cholinergic origin and abnormal neuronal connectivity

This study shows that altering eIF2α phosphorylation in Drosophila models induces dystonia-like movements with cholinergic and D2-receptor origins and altered neuronal connectivity.

Prediction of pathological subthalamic nucleus beta burst occurrence in Parkinson's disease

This paper predicts subthalamic nucleus beta bursts in Parkinson's disease using deep learning, identifying a predictive biomarker for burst onset.

A Computational Model of Deep Brain Stimulation for Parkinsons Disease Tremor

This paper develops a computational model of deep brain stimulation (DBS) to study its effects on Parkinson's disease tremor by simulating cortico-basal ganglia circuitry in healthy and diseased states.

Functions of Direct and Indirect Pathways for Action Selection Are Quantitatively Analyzed in A Spiking Neural Network of The Basal Ganglia

The paper quantitatively analyzes the roles of direct and indirect pathways in action selection within a spiking neural network model of the basal ganglia.

Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson's disease

This study examines how auditory cues affect STN oscillatory activity during stepping in Parkinson's disease, finding differential modulation of beta and transient oscillations.

Model-Based Closed-Loop Control of Thalamic Deep Brain Stimulation

This paper proposes a model-based closed-loop DBS controller for essential tremor using EMG signals, showing it finds DBS frequencies that align with clinical studies.

Gαolf Regulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation

This study characterizes Gnal expression in the mouse brain and shows its role in motor-related neurons through conditional knockout experiments.

Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

This study investigates the anti-manic effects of VTA deep brain stimulation in a methamphetamine-induced mania model, showing both stimulation patterns reduce hyperlocomotion and modulate dopamine dynamics.

An Image Quality Transfer Technique for Localising Deep Brain Stimulation Targets

This paper introduces a transfer learning method to accurately localise the Vim in clinical-quality MRI data by transferring anatomical information from high-quality datasets.

Multi-omics Identify Serotonin Transporter as a Promising Therapeutic Target for Essential Tremor

This study uses multi-omics analysis to identify the serotonin transporter as a potential therapeutic target for essential tremor in a mouse model.