Fungal Infections and Studies

This study compares proteomic profiles of Cryptococcus neoformans clinical strains to identify differences between latent and lethal infections.

The paper identifies mixed plates in a Cryptococcus neoformans knockout collection and proposes an authentication method to distinguish between different KO libraries.

This study identifies multiple genetic routes to thermotolerance in Cryptococcus neoformans through experimental evolution under increasing temperatures.

This study shows that host LSD1 regulates lipid accumulation in macrophages during Cryptococcus neoformans infection by modulating lipophagy and WNT signaling, reducing fungal burden in mice.

The paper detects Histoplasma DNA in soil and bat tissue samples from Brazil, identifying environmental hotspots and multiple bat species as hosts.

The paper investigates the early immune response to Coccidioides in mice, identifying PD-L1+ neutrophils and Spp1+ macrophages as key players in inflammation and fibrosis.

This study uses solid-state NMR to reveal five structural forms of α-glucans in Cryptococcus cell walls, showing their role in scaffolding and interacting with chitin, capsule, and melanin.

This study shows that STRIPAK complex defects in Cryptococcus neoformans lead to pseudosexual reproduction, affecting genome stability and inheritance.

This study shows that pladienolide B inhibits Cryptococcus neoformans growth and spore germination, with enhanced efficacy when combined with FK506 or clorgyline.

This study shows that the absence of PDR6 in Cryptococcus neoformans leads to a hyper-inflammatory immune response in mice, causing immune-dependent tissue damage and death rather than fungal burden.

This study uses timelapse imaging to analyze Cryptococcus neoformans infection dynamics in Galleria mellonella, revealing two distinct mortality phases and deterministic infection progression.

This study shows that Rtf1's HMD domain promotes H2B monoubiquitination and regulates morphogenesis and virulence in Cryptococcus neoformans, independent of Paf1C.

This study adapts the tetracycline-repressible system to regulate essential gene expression in Cryptococcus neoformans, demonstrating its effectiveness in depleting HSP90 and inhibiting fungal growth.

The paper detects airborne Coccidioides spores using UAS-mounted samplers in California, finding Coccidioides DNA in 4.9% of air samples at 8 m height.

This study creates a transcriptomic atlas of Coccidioides development, identifying spherule-enriched transcripts and RYP1-regulated genes critical for virulence.

The paper examines the relationship between soil microbial communities and Coccidioides immitis presence in rodent burrows and surface soils, finding higher microbial diversity in Coccidioides-positive samples.

This study characterizes melanin in Lomentospora prolificans, revealing multiple melanin types and suggesting a new type synthesized alongside DHN-, DOPA-, and pyomelanin.

This study shows that growing Cryptococcus neoformans in unbuffered YNB media improves gene deletion efficiency using short homology arms.

This study shows that polyphosphate mobilization is critical for Cryptococcus neoformans virulence in a mouse model, affecting cell surface structure, immune response, and mitochondrial function.

The paper investigates the distribution of Scedosporium and Lomentospora fungi in Taiwan, finding that human activity, not environmental factors, is the main driver.

This study optimizes in vitro spherulation in Coccidioides by adjusting culture conditions, media composition, and arthroconidium preparation to enhance spherule growth and endospore release.

This study uses single-cell RNA sequencing and spatial transcriptomics to analyze lung immune responses during lethal Coccidioides infection, identifying macrophages and neutrophils involved in fibrosis and immune dysregulation.

This paper investigates how salinity and polysaccharide rafts affect the buoyancy and persistence of Cryptococcus cells in water, with implications for their transport and pathogenic potential.

This paper investigates the role of the STRIPAK complex in Cryptococcus neoformans, showing it regulates genome stability, sexual development, and virulence through functional characterization of its subunits.

The paper characterizes the phenotypic landscape of Cryptococcus neoformans by analyzing gene deletions and their fitness under various conditions, revealing novel biological insights.

This study shows that melanin in Cryptococcus neoformans sequesters calcium, impairing polysaccharide capsule formation and leading to increased shed polysaccharide that may affect host immunity.

This study identifies AcuK and AcuM as global regulators in Talaromyces marneffei that control iron homeostasis, gluconeogenesis, and oxidative stress response during macrophage infection.

The paper shows milteforan, a veterinary product containing miltefosine, is effective against sporotrichosis caused by S. brasiliensis and S. schenckii in vitro and in infected cells.