Bacteriophages and microbial interactions

This study shows that multidrug resistance plasmids face a trade-off between phage resistance and conjugative ability, which affects their evolutionary response to plasmid-dependent phages.

This study investigates the functional roles of thioredoxin and cve genes in marine cyanophages, showing thioredoxin enhances phage fitness and virulence, while cve improves virulence despite reducing progeny production.

This paper engineers bacteriophages with iron nanoparticles to enable magnetic guidance, improving their targeting of biofilms and reducing systemic effects in vivo.

The paper shows CRISPR immunity in Pseudomonas aeruginosa varies in fitness benefit against virulent phages, depending on the likelihood of evolving receptor-based resistance through spontaneous mutations.

This study identifies diel rhythms in viral communities across domains of life, showing significant fluctuations in abundance and transcriptional activity, with NCLDVs showing nocturnal patterns linked to host cycles.

This study evaluates a three-phage cocktail's in vitro efficacy against three gastrointestinal pathogens, showing enhanced suppression in mixed cultures but regrowth in single cultures due to resistance.

The paper identifies phage defense systems by analyzing modular gene clusters, validating three new systems through experimental testing.

This study shows that prophage induction states in marine bacteria influence biofilm structure and competitive outcomes, revealing synergistic effects in co-cultures through phage-mediated interactions.

The paper introduces Droplet RB-TnSeq to study phage-host interactions by isolating single mutant cells with defined phage titers, identifying host factors beyond receptor-level interactions.

This study uses Cryo-ET to analyze the infection mechanism of {Phi}8 in Pseudomonas syringae pv. phaseolicola, revealing key stages of viral assembly and extracellular virion localization.

The paper expands the database of giant virus genomes, identifies new viral taxa and functions, and highlights potential biotechnological applications.

The paper examines viral metabolism in coral reefs, finding that lytic viruses consume central carbon intermediates for virion production, while temperate viruses build them, leading to distinct ecosystem states.

This study shows that type IV pili in marine cyanobacteria increase phage encounter, leading to higher viral infection rates and competitive disadvantage in mixed populations.

This study compares gut virome composition across ancient and modern human populations, finding increased similarity and shifts toward temperate lifestyles and bacterial pathogenicity with industrialization.

The paper shows that endogenous viral elements in brown algae can reactivate, replicate, and transmit viruses, challenging the view of EVEs as inert.

Fine-tuned Evo 1 and Evo 2 genome language models designed complete ΦX174-like phage genomes; 16 of 285 assembled designs were viable, and some outperformed ΦX174 in competition.

This study characterizes phage-plasmids in clinical Enterobacteriaceae isolates, finding they are common and associated with antimicrobial resistance and disease severity.

This study shows that biological complexity affects virus-host dynamics by altering population-level lysis, mutation rates, and evolutionary trajectories.

The paper investigates the role of phage-mediated selection in shaping Cutibacterium acnes populations on human skin and finds weak phage pressure due to physical barriers limiting phage exposure.

The paper catalogs 105 recombinant Klebsiella phage depolymerases, classifying them by sequence, structure, and substrate specificity, revealing diverse enzyme functions and evolutionary patterns.

This study shows phage-encoded homing endonucleases reduce bacterial immunity by inhibiting GAPS4, a DNase defense system, thereby enhancing phage fitness.

The paper identifies viral species in gastric tumor and peritumoral tissues, finding enriched viruses and comparable diversity between tissue types.

PhageAI predicts bacteriophage lifestyle using proteinBERT and CNNs, addressing data scarcity and explainability issues in phage lifecycle classification.

This study identifies novel bacterial pathways involved in phage resistance in Staphylococcus aureus and shows how these mutations affect antibiotic susceptibility and virulence.

This paper develops a phage-mediated system for just-in-time amplification and delivery of production circuits in E. coli to express toxic proteins without chemical inducers or leaky expression.

The paper identifies how Gabija, a bacterial anti-phage system, discriminates self from non-self DNA by targeting phages that antagonize the host RecBCD complex.

The paper identifies the spike tip protein of bacteriophage T4 and shows its essential role in infection of bacteria with truncated lipopolysaccharides.

The paper presents the first genomic catalogue of viruses and mobile genetic elements associated with Nitrososphaeria, revealing novel viral families and insights into their evolution and adaptation.

The paper analyzes the evolution of 3425 actinobacteriophage genomes, finding conserved synteny and varying linkage decay patterns due to homologous recombination.

The paper identifies Jug phages as prevalent in human and animal gut microbiomes, showing high transcription activity and potential ecological significance.