Bacteriophages and microbial interactions

This study identifies AbiV as an RNase in the bacterial antiphage system AbiV, revealing its structure, function, and mechanism of action.

The paper identifies bacterial receptor genes determining phage host range, showing defense mechanisms are not predictive of susceptibility.

The paper introduces MANIAC, a tool for estimating ANI and AF in viral genomes, revealing an ANI gap in bacterial dsDNA viruses and showing its predictive power for taxonomy.

This paper identifies a new SH3b_T family of CBDs in staphylococcal phage endolysins and shows how sequence differences and EAD-CBD combinations influence binding specificity and activity.

The paper introduces PHAGEPACK, a CRISPR-based assay to systematically identify host genes affecting phage infectivity, revealing new pathways in both permissive and non-permissive E. coli.

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

This study identifies NAD-capped RNAs during T4 phage infection of E. coli, showing dynamic changes in NAD-capping and revealing a phage-encoded Nudix hydrolase involved in NAD-RNA decapping.

This study explores horizontal gene transfer among animal viruses by analyzing sequencing data, revealing chimeric structures and new viral groups.

This study examines how bacterial defenses and growth rates vary across ecological contexts, finding that defense systems are not universally present and depend on factors like habitat and nutrient availability.

The paper discovers a new group of DNA viruses, egoviruses, found in the digestive systems of humans and animals, closely related to poxviruses and suggesting an evolutionary link between gut-infecting viruses and animal pathogens.

This study identifies mobile genetic elements and defense systems in Asgard archaea, revealing their role in shaping genetic diversity and evolution.

The paper identifies PSB15 as a protein essential for integrative filamentous phage assembly, showing it binds packaging signals and interacts with host proteins to regulate the assembly checkpoint.

This study evolves a virulent phage to expand its host range and increase virulence, finding convergent mutations in key genes.

This study analyzes RNA virus diversity in wastewater treatment plants, identifying new viral lineages and their ecological and health implications.

This paper predicts phage-host interactions using deep learning and pre-trained language models, achieving a 73.76% weighted F1-score.

The paper develops a computational pipeline to classify phage receptor-binding proteins and predicts surface glycopolymer structure in Staphylococcus pathogens.

This study characterizes a novel LysinB from a mycobacteriophage, showing its lytic activity against Mycobacterium smegmatis and potential as an antimycobacterial agent.

The paper identifies a novel pentose modification on cytosine in phage DNA that enhances resistance to host restriction systems.

This study identifies a DNA-bending protein in Mimivirus essential for genome condensation and viral replication.

The paper presents a method to discover new human gut viruses using enriched virome samples and reports over 162,000 novel viral sequences.

This study identifies and characterizes a novel LysinB from Mycobacterium fortuitum prophages, revealing its structural and functional domains and their roles in antibacterial activity.

The paper announces and analyzes five new mycobacteriophages from clusters F, G, K, and P, contributing to the diversity of sequenced mycobacteriophages.

The paper shows that the M protein of S. pyogenes contributes to resistance against phage A25 infection in human serum by binding IgG and albumin, especially in the absence of fatty acids.

The paper identifies new antiviral defence systems in prokaryotes by analyzing genetic embedding of uncharacterized genes within known defence systems.

This study investigates the role of SV isoforms of the staphylococcal phage φ2638A endolysin during infection, showing they form heterodimers with the full-length endolysin to enhance lytic activity.

The paper predicts stop codon reassignment in bacteriophage genomes to improve functional annotation, showing significant increases in gene length and coding density.

This study reveals the structure and mechanism of the Zorya anti-phage defense system using cryo-EM and functional assays, showing how it detects phage invasion and activates defense.

The paper uses Hi-C to assemble nearly complete microbial and viral genomes from an estuarine sample, revealing virus-microbe interactions and a broad host range for a cyanophage.

This study demonstrates that Ms6LysB can impair M. tuberculosis growth and retain lytic properties when internalized by macrophages, suggesting its potential as a new therapeutic strategy.

The paper characterizes dsDNA viruses infecting nitrifying archaea and bacteria in soil using targeted enrichment and metagenomic analysis, revealing novel viral lineages and host-virus interactions.