Helminth infection and control

Characterisation of a Teladorsagia circumcincta glutathione transferase.

This paper characterizes a glutathione transferase from Teladorsagia circumcincta, analyzing its sequence, structure, and immunogenic properties.

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles

This study demonstrates that five beta-tubulin alleles confer benzimidazole resistance in parasitic nematodes and shows that E198V reduces fitness in the absence of the drug.

RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development

This study investigates RNAi dynamics in developing juvenile Fasciola hepatica, finding reduced RNAi efficacy in early stages and improved efficiency with repeated dsRNA exposure.

Molecular characterization of Fasciola gigantica in Punjab, Pakistan to infer the dispersal route among the neighbouring countries of the Indian subcontinent

The paper characterizes Fasciola gigantica in Punjab, Pakistan, identifying genetic differences and potential dispersal routes among neighboring countries in the Indian subcontinent.

Genetic analysis confirms the presence of Dicrocoelium dendriticum in the Himalaya ranges of Pakistan.

The paper confirms the presence of Dicrocoelium dendriticum in the Himalaya ranges of Pakistan using genetic analysis of flukes collected from the Chitral valley.

Draft genome of the liver fluke Fasciola gigantica

The paper presents the first draft genome of Fasciola gigantica, revealing insights into its metabolic pathways and potential host dependency for fatty acid acquisition.

Genetic diversity and multiplicity of infection in Fasciola gigantica isolates of Pakistani livestock

The paper analyzes genetic diversity and multiplicity of infection in Fasciola gigantica isolates from Pakistani livestock using mt-ND-1 locus sequencing.

Characterisation of gastrointestinal helminths and their impact in commercial small-scale chicken flocks in the Mekong Delta of Vietnam

The paper investigates gastrointestinal helminth prevalence and impact in small-scale chicken flocks in Vietnam, finding higher worm burdens in diseased birds and seasonal variation in colonization.

The global diversity of the major parasitic nematode Haemonchus contortus is shaped by human intervention and climate

This study analyzes the global genetic diversity of Haemonchus contortus, revealing human-driven dispersal and climate adaptation mechanisms.

Evidence for the F200Y (TAC) mutation conferring benzimidazole resistance in a southern USA cattle population of Haemonchus placei spreading from a single emergence

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

The paper identifies a single major QTL on chromosome V associated with ivermectin resistance in Haemonchus contortus through genome-wide analysis of genetic crosses.

Development of high throughput methods for the analysis of anthelmintic resistance allele frequencies in field populations of gastrointestinal nematodes.

The paper develops a high-throughput method to determine anthelmintic resistance allele frequencies in gastrointestinal nematodes using Illumina Mi-seq sequencing.

Emergence and the spread of the F200Y benzimidazole resistance mutation in Haemonchus contortus and Haemonchus placei from buffalo and cattle

The paper identifies the F200Y mutation as a common benzimidazole resistance mutation in Haemonchus contortus and H. placei in buffalo and cattle, showing multiple emergence events in H. contortus and a single emergence in H. placei.

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles

This study identifies extreme allelic heterogeneity in the ben-1 gene of C. elegans as a major determinant of natural resistance to albendazole, revealing multiple mechanisms of benzimidazole resistance.

Discovery of unique loci that underlie nematode responses to benzimidazoles

The paper identifies QTL associated with benzimidazole resistance in nematodes using genetic mapping and phenotyping.

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes

This paper identifies 146 GPCRs in Fasciola hepatica, including 18 unique rhodopsins, and provides ligand-receptor predictions, offering potential targets for new anthelmintic drugs.

A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry

This paper constructs a genetic map of Haemonchus contortus using whole-genome resequencing, revealing recombination patterns and reproductive traits like polyandry and polyploidy.

Metagenomic signature of natural strongyle infection in susceptible and resistant horses

This study identifies gut microbiota differences between susceptible and resistant horses infected with strongyles, linking microbial composition to immune responses and infection outcomes.

Transcriptomic profiling of nematode parasites surviving after vaccine exposure

The paper compares the transcriptome of Haemonchus contortus parasites from vaccinated and control sheep to assess vaccine-induced gene expression changes.