Spondyloarthritis Studies and Treatments

Refinement of the Pathogenic T Cell Receptor Motif Suggests Type 17 CD8+ T Cells Initiate HLA-B*27-associated Autoimmunity

The paper identifies a broader pathogenic T cell receptor motif linked to HLA-B*27-associated autoimmune diseases and shows these T cells express a Type 17 program.

Joint tissue explant model using psoriatic arthritis synovial fluid as a tool to capture patient-specific responses to treatments

This study develops a patient-specific explant model using psoriatic arthritis synovial fluid to evaluate treatment responses in PsA.

Genome-wide meta-analysis and integrative fine-mapping identify novel susceptibility loci and effector genes in psoriatic arthritis

This study identifies 40 novel susceptibility loci for psoriatic arthritis through GWAS and fine-mapping, including new therapeutic targets and disease-relevant cell types.

Beyond the Shared Inflammatory Axis: Differentiating Molecular Signatures in Psoriatic Arthritis and Ankylosing Spondylitis through Integrated Omics

This study compares transcriptomic signatures of psoriatic arthritis and ankylosing spondylitis to identify shared and distinct molecular features using integrative omics approaches.

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis

The paper identifies shared CD8+ T-cell clones between skin and joint in psoriatic arthritis, suggesting clonal migration and coordinated inflammation.

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovium tissue

This study identifies CD4+ tissue-resident memory Th17 (TRM17) cells as the main source of IL-17A in SpA synovium, showing their role in disease pathology and potential as therapeutic targets.

Deciphering Metabolic Pathways and Protein-Protein Interaction Networks in Ankylosing Spondylitis through Single-Cell RNA Sequencing

This study uses scRNA-seq data to analyze metabolic pathways and protein-protein interaction networks in Ankylosing Spondylitis, identifying RPS11 as a key hub in immune cells.

AxSpA joint tissue is characterised by HLA-DR+ tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)+ CD8+ T cell subsets

This study profiles CD8+ T cells in AxSpA synovium using scRNA-seq, identifying HLA-DR+ TRM and KIR+ subsets with distinct transcriptional features and potential pathogenic roles.

Rare coding variants in NOX4 link high superoxide levels to psoriatic arthritis mutilans

The paper identifies rare NOX4 variants in psoriatic arthritis mutilans patients that increase ROS levels, linking them to disease pathogenesis and suggesting therapeutic targets.

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of RUNX3 promoter

The paper investigates how genetic variants associated with ankylosing spondylitis affect c-MYC binding and chromosomal looping near the RUNX3 promoter.

HLA-B27 and not variation in MICA is responsible for genotype by sex interaction in risk of Ankylosing Spondylitis

The paper investigates a genotype by sex interaction in Ankylosing Spondylitis risk, showing it is driven by HLA-B rather than MICA variation.

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

This study identifies ATF6 as a regulator of angiogenesis-osteogenesis coupling in ankylosing spondylitis by enhancing FGF2 expression in chondrocytes.

A RUNX3 enhancer polymorphism associated with ankylosing spondylitis influences recruitment of Interferon Regulatory Factor 5 and factors of the Nucleosome Remodelling Deacetylase Complex in CD8+ T-cells

The paper investigates how a polymorphism in a RUNX3 enhancer affects TF binding in CD8+ T-cells, linking it to ankylosing spondylitis risk.

Identification of key candidate genes and pathways in axial Spondyloarthritis through integrated bioinformatics analysis

The paper identifies key genes and pathways in axial spondyloarthritis through bioinformatics analysis of gene expression data and experimental validation.