Viral Infections and Immunology Research

Enterovirus D68 2A protease causes nuclear pore complex dysfunction and independently contributes to motor neuron toxicity

This study shows that EV-D68 2A protease disrupts nuclear pore complex function and causes motor neuron toxicity independently of viral replication.

Enterovirus D68 VP1 and VP3 determine neurotropism in human spinal cord organoids

The paper investigates how mutations in EV-D68's VP1 and VP3 proteins affect neurotropism in human spinal cord organoids and links these findings to reduced neurovirulence observed after 2018.

Complete Genome Sequencing and Molecular Characterization of Indigenous Enterovirus A71 Genogroups D and G of India

The paper characterizes two indigenous EV-A71 genogroups (D and G) from India through genome sequencing and phylogenetic analysis, revealing their distinct evolutionary paths and geographic restriction.

Recombinant B3 clade enterovirus D68 strains are efficiently rescued in 293T cells and infect human spinal cord organoids.

This study develops a method to rescue B3 clade EV-D68 strains and shows they replicate more efficiently in spinal cord organoids than a neurovirulent B2 clade strain.

Non-polio enteroviruses compromise the electrophysiology of a human iPSC-derived neural network

This study investigates how EV-D68 and EV-A71 affect neural activity in human iPSC-derived neural co-cultures, finding virus-specific disruptions without correlation to replication efficiency.

Humoral correlates of protection in a mouse model of echovirus infection

This study develops a mouse model of echovirus infection and identifies humoral correlates of protection against the virus.

Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditis

This study uses spatial transcriptomics to show that myocarditis involves widespread molecular changes in cardiomyocytes, not just immune cell areas.

Development of enterovirus trans-encapsidation assays as tools to understand viral entry.

This paper develops trans-encapsidation assays to study enterovirus entry, uncoating, and replication using reporter replicons and structural proteins expressed in trans.

Strain-Specific Tropism and Transcriptional Responses of Enterovirus D68 Infection in Human Spinal Cord Organoids

This study uses scRNA-seq to analyze EV-D68 infection in human spinal cord organoids, revealing strain-specific tropism and host transcriptional responses associated with AFM.

Sialic acid-containing glycolipids extend the receptor repertoire of Enterovirus-D68

This study identifies sialic acid-containing glycolipids as novel receptors for EV-D68 and shows that different strains prefer distinct sialic acid linkages.

Immune cells promote paralytic disease in mice infected with enterovirus D68

This study shows that immune cell infiltration into the spinal cord promotes paralysis in mice infected with EV-D68, suggesting immune cell targeting as a therapeutic strategy.

Novel murine model of human astrovirus infection reveals a cardiovascular tropism

This paper develops a novel murine model of human astrovirus infection, revealing a cardiovascular tropism and immune response mechanisms.

Three Modes of Viral Adaption by the Heart

The paper identifies three host transcriptome adaptions in heart infections by cardio-pathogenic viruses, which are independent of the virus and reversible through pathway perturbation.

Single-cell virology: On-chip, quantitative characterization of the dynamics of virus spread from one single cell to another

This study uses a microfluidic device to characterize lytic and non-lytic virus spread between single cells, finding non-lytic spread is faster and more efficient.

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

This study shows CVB3 infection upregulates ASS1 through citrulline consumption, leading to metabolic reprogramming and macrophage inflammatory polarization, contributing to viral myocarditis.

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis

This study uses spatiotemporal transcriptomics to map reovirus-induced myocarditis in neonatal mice, revealing immune responses and cellular interactions in the heart and intestine.

Characterization of Coxsackievirus A20 from a child with acute flaccid paralysis in Nigeria

The paper characterizes a Coxsackievirus A20 strain from a child with acute flaccid paralysis in Nigeria and identifies its role in recombinant cVDPV2 outbreaks.

Genetic diversity of the enteroviruses detected from Cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017

The paper analyzes genetic diversity of enteroviruses in CSF samples from patients with suspected aseptic meningitis in Palestine, identifying prevalent genotypes and their clinical associations.