Topic · Epidemiology · Medicine

Respiratory viral infections research

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

98 papers

Infant RSV immunoprophylaxis changes nasal epithelial DNA methylation at six years of age

Cheng‐Jian Xu, Nienke M. Scheltema, Cancan Qi, Rolf Vedder, Laura B. C. Klein, Elisabeth E. Nibbelke, Cornelis Korstiaan van der Ent, Louis Bont, Gerard H. Koppelman

This study shows that infant RSV immunoprophylaxis with palivizumab alters nasal epithelial DNA methylation at age 6, affecting antiviral defense pathways but not asthma.

Pediatric Pulmonology · Sep 2, 2021Peer-reviewedGenetic & Genomic Medicine

Molecular epidemiology of human respiratory syncytial virus with severe acute respiratory infection in Huzhou from 2016 to 2019

Deshun Xu, Lei Ji, Xiaofang Wu, Wei Yan, Liping Chen

The paper analyzes HRSV circulation in Huzhou, China, from 2016 to 2019, finding co-circulation of subgroups A and B with highest infection rates in infants.

bioRxiv · Feb 15, 2021 · PreprintMolecular Biology

Genomics of Human Respiratory Syncytial Virus Vaccine Attenuation

Thomas Junier, Laurent Kaiser, Nimisha Chaturvedi, Tina V. Hartert, Jacques Fellay

The paper identifies mutations frequent in HRSV vaccine candidates and rare in wild-type genomes that may contribute to vaccine attenuation.

bioRxiv · Oct 21, 2020 · PreprintGenomics

Respiratory Syncytial Virus Infections Induce Hypermetabolism in Pediatric Upper Airways

Svetlana Rezinciuc, Lavanya Bezavada, Azadeh Bahadoran, Jesse F. Ingels, Young-Yin Kim, Stephania A. Cormier, John P. DeVincenzo, Barry Lynn Shulkin, Heather S. Smallwood

This study shows RSV infection increases metabolism in pediatric upper airway cells and fluids, suggesting hypermetabolism as a potential therapeutic target.

bioRxiv · Jul 18, 2020 · PreprintSystems Biology

Respiratory Syncytial Virus in Infants and Children with Prader-Willi syndrome.

JL Miller, E Thornton

This study examines RSV infection rates, hospitalization, and outcomes in children with Prader-Willi syndrome, finding high infection rates and severe complications, with recommendations for improved vaccination and healthcare access.

bioRxiv · Jun 23, 2020 · PreprintGenetics

Genotype-dependent and non-gradient patterns of RSV gene expression

Felipe-Andrés Piedra, Xueting Qiu, Michael N. Teng, Vasanthi Avadhanula, Annette A. Machado, Do-Kyun Kim, James E. Hixson, Justin Bahl, Pedro A. Piedra

This study shows RSV gene expression is genotype-dependent and non-gradient, with the G gene consistently more expressed than upstream genes, suggesting a novel transcriptional regulation mechanism involving GS signal N-phase alignment.

PLoS ONE · Jan 10, 2020Peer-reviewedMolecular Biology

Insufficiency in airway interferon activation defines clinical severity to infant RSV infection

Chin‐Yi Chu, Xing Qiu, Matthew N. McCall, Lu Wang, Anthony M. Corbett, Jeanne Holden‐Wiltse, Christopher G. Slaunwhite, Qian Wang, Christopher Anderson, Alex Grier, Steven R. Gill, Gloria Pryhuber, Ann Regina Falsey, David J. Topham, Mary T. Caserta, , Thomas J. Mariani

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.

bioRxiv · May 20, 2019 · PreprintGenomics

FilmArray Respiratory Panel Integrated in a field Point Of Care dispositive for the diagnosis of respiratory tract infections in rural areas in Senegal

Hubert Bassène, Sophie Edouard, Georges Diatta, Jean‐Christophe Lagier, Oleg Mediannikov, Florence Fenollar, Aldiouma Diallo, El Hadji Ba, Didier Raoult, Philippe Parola, Michel Drancourt, Cheikh Sokhna

This study evaluates the use of the FilmArray respiratory panel in a field Point of Care (POC) setting in rural Senegal to diagnose respiratory tract infections, finding higher pathogen prevalence in children under 5 and seasonal variations.

bioRxiv · Dec 22, 2018 · PreprintMolecular Biology