dental development and anomalies

Cellular basis of accelerated whole-tooth regeneration

The paper studies tooth regeneration in cichlid fishes, identifying accelerated replacement and cellular interactions involved in the process.

Whole Exome Sequencing Uncovers Key Genetic Variants in Congenital Tooth Agenesis: An Integrative Omics Approach

This study uses whole exome sequencing and multi-omics integration to identify genetic variants associated with congenital tooth agenesis, revealing potential biomarkers and therapeutic targets.

Reduced Dietary Protein Induces Changes in the Dental Proteome

The paper uses quantitative proteomics to show that a low-protein diet during development alters protein expression in mouse molars without affecting size or skull length.

Ectodysplasin overexpression reveals spatiotemporally dynamic tooth formation competency in stickleback and zebrafish

This study shows that overexpressing Ectodysplasin (Eda) in sticklebacks and zebrafish can induce tooth formation in multiple oropharyngeal and cranial domains, revealing dynamic spatial and temporal competency for ectopic tooth initiation.

Teeth Outside the Jaw: Evolution and Development of the Toothed Head Clasper in Chimaeras

This study investigates the development and evolutionary origin of extraoral teeth in chimaeras, finding they develop similarly to oral teeth and are homologous rather than modified denticles.

Tooth development in frogs: Implications for the re-evolution of lost mandibular teeth and the origin of a morphological innovation

This study investigates tooth development in frogs, finding that the upper jaw retains a conserved tooth gene network, while the mandible lacks evidence of tooth development, suggesting evolutionary constraints on re-evolving lost mandibular teeth.

KMT2d regulates tooth enamel development

This study investigates the role of KMT2D in amelogenesis using a conditional knockout mouse model, revealing its critical role in enamel development and identifying direct target genes involved in ameloblast differentiation.

Modulation of tooth regeneration through opposing responses to Wnt and BMP signals in teleosts

The paper investigates the role of Wnt and BMP signaling in tooth regeneration in fish, finding that Wnt promotes and BMP inhibits regeneration, similar to hair regeneration.

The developmental basis for scaling of mammalian tooth size

The paper investigates how mammalian molar teeth scale during development and evolution, finding that the IGF pathway regulates both growth and cusp patterning to achieve size differences.

Ectodysplasin signaling via Xedar is required for mammary gland morphogenesis

This study investigates the role of XEDAR in mammary gland development using a mouse knockout model, showing its specific role in post-pubertal growth and branching.

Teeth outside the mouth: the evolution and development of shark denticles

This study examines the development of shark denticles, finding they share a gene expression signature with teeth but lack a stem cell niche for regeneration.

An in vitro and computational validation of a novel loss-of-functional mutation in PAX9 associated with non-syndromic tooth agenesis

The paper identifies a novel PAX9 mutation causing non-syndromic tooth agenesis through in vitro and computational analysis.

Understanding the development of oral epithelial organs through single cell transcriptomic analysis

This study maps the transcriptional landscape of developing mouse mandibular epithelium to identify key transcription factors and gene regulatory networks involved in oral epithelial patterning and organ specification.

An ancient dental signalling centre supports homology of an enamel knot in sharks

The paper shows that an enamel knot-like signalling centre is conserved in sharks, supporting its homology across vertebrates despite differences in signalling.

FGF8-mediated signaling regulates tooth developmental pace during odontogenesis

This study shows that FGF8 signaling in the dental mesenchyme slows tooth development by promoting cell proliferation and blocking apoptosis.

Distinct tooth regeneration systems deploy a conserved battery of genes

The paper compares tooth regeneration systems in zebrafish and stickleback to show they use a conserved set of genes during regeneration.

Spectrum of pathogenic variants and multiple founder effects in amelogenesis imperfecta associated with MMP20

The paper identifies new pathogenic variants in the MMP20 gene associated with autosomal recessive amelogenesis imperfecta and explores their genetic origins across different populations.

Anomalous incisor morphology indicates tissue-specific roles for Tfap2a and Tfap2b in tooth development

This study shows that Tfap2a and Tfap2b have tissue-specific roles in tooth development, with epithelial expression critical for incisor morphology and mesenchymal expression having little effect.

System-level analyses of keystone genes required for mammalian tooth development

The paper identifies developmental keystone genes in mouse and rat tooth development by analyzing phenotypic severity and gene expression patterns, revealing conserved system-level dynamics.

Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning

The paper models Edar expression dynamics to reveal hidden patterning processes in tooth signaling centers, showing a two-step activation and erasure mechanism.

A de novo EDA-variant in a litter of shorthaired standard Dachshunds with X-linked hypohidrotic ectodermal dysplasia

The paper identifies a de novo EDA mutation causing X-linked hypohidrotic ectodermal dysplasia in shorthaired standard Dachshunds through whole-genome sequencing and family analysis.

Unbiased association and expression studies identify novel genes for tooth development

The paper identifies novel genes for tooth development by associating CRC risk variants with tooth agenesis and showing gene expression in developing teeth.

Zebrafish sp7 mutants show tooth cycling independent of attachment, eruption and poor differentiation of teeth

This study shows that zebrafish lacking sp7 can replace teeth without attachment bone, but with poor differentiation and abnormal tooth orientation.

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells (MSCs)

This study shows BMP signaling is required for MSC lineage commitment and identifies downstream transcription factors that determine cellular identities in dental mesenchyme.