Erythrocyte Function and Pathophysiology

Erythrocyte aging links hypocalcemia to impaired flow dynamics and oxygen transport through volume dysregulation

This study shows that aging red blood cells rely on calcium for volume stability under shear stress, and impaired calcium regulation leads to flow and oxygen transport issues.

A Practical Assay for Assessing Mean Red Blood Cell Age Using the Protein 4.1a/4.1b Ratio

This paper develops a low-volume method to measure the 4.1a/4.1b protein ratio in red blood cells to estimate mean RBC age, showing significant interindividual variation.

Robust High-Throughput Flickering Spectroscopy for Measurements of Red Blood Cell Membrane Mechanics

This paper develops a high-throughput flickering spectroscopy method to measure red blood cell membrane mechanics, validated through chemical modification and simulations.

Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters

The paper identifies a membrane-feedback mechanism that converts single-channel mechanosensing into self-organized Piezo1 clusters through density and tension-dependent interactions.

Otenabant is a Selective Antagonist of Human PIEZO1

The paper identifies Otenabant, a CB1 antagonist, as a potent and selective PIEZO1 inhibitor through high-throughput screening and validates its effects across multiple assays.

Cannabidiol Inhibits PIEZO Channels to Mitigate Red Blood Disorders

This paper shows that cannabidiol inhibits PIEZO channels in red blood cells, reducing calcium overload and related pathologies in hereditary xerocytosis and sickle cell disease.

A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channel

This paper investigates the structural and functional changes in the PIEZO1-R2482H mutant, revealing a non-swapped pore and altered gating cycle that explain its heightened mechanosensitivity and slowed inactivation.

Canonical nuclear envelope protein emerin regulates structure and integrity of the erythrocyte plasma membrane

This study shows emerin, a nuclear envelope protein, is expressed in red blood cells and regulates membrane structure and function, with mutations linked to RBC phenotypes like MCV.

Role of channels in the O2 permeability of murine red blood cells II. Morphological and proteomic studies

This paper examines RBC morphology and proteomics in mice, finding no significant differences in shape or protein content that could explain changes in O2 permeability observed in prior studies.

Role of channels in the O2 permeabilityof murine red blood cells. I. Stopped-flow and hematological studies

This paper investigates O2 permeability in murine red blood cells, showing that membrane channels, not lipid diffusion, are critical for O2 transport, with AQP1 and RhAG contributing significantly.

Computational analysis of the plasmodium falciparum-induced intraerythrocyte deformations: insights into malaria parasite egress mechanics and eryptosis

This paper develops a computational model to study how Plasmodium falciparum-induced mechanical deformations of erythrocytes relate to eryptosis and parasite egress.

Clinical manifestations and phenotypic analysis of new ANK1 gene mutations in 12 Chinese children with hereditary spherocytosis

The paper identifies new ANK1 gene mutations in 12 Chinese children with hereditary spherocytosis and evaluates their clinical and genetic implications.